Search Results - "Mueller, Geoffrey"

Structural Aspects of the Allergen-Antibody Interaction by Pomés, Anna, Mueller, Geoffrey A, Chruszcz, Maksymilian

“…The development of allergic disease involves the production of IgE antibodies upon allergen exposure in a process called sensitization. IgE binds to receptors…”
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ZATT (ZNF451)–mediated resolution of topoisomerase 2 DNA-protein cross-links by Schellenberg, Matthew J., Lieberman, Jenna Ariel, Herrero-Ruiz, Andrés, Butler, Logan R., Williams, Jason G., Muñoz-Cabello, Ana M., Mueller, Geoffrey A., London, Robert E., Cortés-Ledesma, Felipe, Williams, R. Scott

“…Topoisomerase 2 (TOP2) DNA transactions proceed via formation of the TOP2 cleavage complex (TOP2cc), a covalent enzyme-DNA reaction intermediate that is…”
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Contributions and Future Directions for Structural Biology in the Study of Allergens by Mueller, Geoffrey A

“…Allergy is defined as an inappropriate immune response to something normally considered harmless. The symptomatic immune response is driven by IgE antibodies…”
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The translational repressor Glorund uses interchangeable RNA recognition domains to recognize Drosophila nanos by Warden, Meghan S, DeRose, Eugene F, Tamayo, Joel V, Mueller, Geoffrey A, Gavis, Elizabeth R, Hall, Traci M Tanaka

“…Abstract The Drosophila melanogaster protein Glorund (Glo) represses nanos (nos) translation and uses its quasi-RNA recognition motifs (qRRMs) to recognize…”
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Characterizing the mechanism of action of double-stranded RNA activity against western corn rootworm (Diabrotica virgifera virgifera LeConte) by Bolognesi, Renata, Ramaseshadri, Parthasarathy, Anderson, Jerry, Bachman, Pamela, Clinton, William, Flannagan, Ronald, Ilagan, Oliver, Lawrence, Christina, Levine, Steven, Moar, William, Mueller, Geoffrey, Tan, Jianguo, Uffman, Joshua, Wiggins, Elizabeth, Heck, Gregory, Segers, Gerrit

“…RNA interference (RNAi) has previously been shown to be effective in western corn rootworm (WCR, Diabrotica virgifera virgifera LeConte) larvae via oral…”
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The novel structure of the cockroach allergen Bla g 1 has implications for allergenicity and exposure assessment by Mueller, Geoffrey A., PhD, Pedersen, Lars C., PhD, Lih, Fred B., BA, Glesner, Jill, BS, Moon, Andrea F., MS, Chapman, Martin D., PhD, Tomer, Kenneth B., PhD, London, Robert E., PhD, Pomés, Anna, PhD

“…Background Sensitization to cockroach allergens is a major risk factor for asthma. The cockroach allergen Bla g 1 has multiple repeats of approximately 100…”
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Multiple roles of Bet v 1 ligands in allergen stabilization and modulation of endosomal protease activity by Soh, Wai Tuck, Aglas, Lorenz, Mueller, Geoffrey A., Gilles, Stefanie, Weiss, Richard, Scheiblhofer, Sandra, Huber, Sara, Scheidt, Tamara, Thompson, Peter M., Briza, Peter, London, Robert E., Traidl‐Hoffmann, Claudia, Cabrele, Chiara, Brandstetter, Hans, Ferreira, Fatima

“…Background Over 100 million people worldwide suffer from birch pollen allergy. Bet v 1 has been identified as the major birch pollen allergen. However, the…”
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Immunotherapy-induced neutralizing antibodies disrupt allergen binding and sustain allergen tolerance in peanut allergy by LaHood, Nicole A, Min, Jungki, Keswani, Tarun, Richardson, Crystal M, Amoako, Kwasi, Zhou, Jingjia, Marini-Rapoport, Orlee, Bernard, Hervé, Hazebrouck, Stéphane, Shreffler, Wayne G, Love, J Christopher, Pomes, Anna, Pedersen, Lars C, Mueller, Geoffrey A, Patil, Sarita U

“…In IgE-mediated food allergies, exposure to the allergen activates systemic allergic responses. Oral immunotherapy (OIT) treats food allergies through…”
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Abundance and Stability as Common Properties of Allergens by Foo, Alexander C Y, Mueller, Geoffrey A

“…There have been many attempts to identify common biophysical properties which differentiate allergens from their non-immunogenic counterparts. This review will…”
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Expanding the antiviral potential of the mosquito lipid‐transfer protein AEG12 against SARS‐CoV‐2 using hydrophobic antiviral ligands by Foo, Alexander C. Y., Lafont, Bernard A. P., Mueller, Geoffrey A.

“…The mosquito protein AEG12 encompasses a large (~ 3800 Å3) hydrophobic cavity which binds and delivers unsaturated fatty acids into biological membranes,…”
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Allergens and their associated small molecule ligands—their dual role in sensitization by Chruszcz, Maksymilian, Chew, Fook Tim, Hoffmann‐Sommergruber, Karin, Hurlburt, Barry K., Mueller, Geoffrey A., Pomés, Anna, Rouvinen, Juha, Villalba, Mayte, Wöhrl, Birgitta M., Breiteneder, Heimo

“…Many allergens feature hydrophobic cavities that allow the binding of primarily hydrophobic small‐molecule ligands. Ligand‐binding specificities can be strict…”
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Precision engineering for localization, validation, and modification of allergenic epitopes by Pomés, Anna, Smith, Scott A., Chruszcz, Maksymilian, Mueller, Geoffrey A., Brackett, Nicole F., Chapman, Martin D.

“…The allergen-IgE interaction is essential for the genesis of allergic responses, yet investigation of the molecular basis of these interactions is in its…”
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Characterization of the Activity Spectrum of MON 88702 and the Plant-Incorporated Protectant Cry51Aa2.834_16 by Bachman, Pamela M, Ahmad, Aqeel, Ahrens, Jeffrey E, Akbar, Waseem, Baum, James A, Brown, Scott, Clark, Thomas L, Fridley, Jennifer M, Gowda, Anilkumar, Greenplate, John T, Jensen, Peter D, Mueller, Geoffrey M, Odegaard, Matthew L, Tan, Jianguo, Uffman, Joshua P, Levine, Steven L

“…The spectrum of insecticidal activity of Cry51Aa2.834_16 protein targeting hemipteran and thysanopteran insect pests in cotton was characterized by selecting…”
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Independent action between DvSnf7 RNA and Cry3Bb1 protein in southern corn rootworm, Diabrotica undecimpunctata howardi and Colorado potato beetle, Leptinotarsa decemlineata by Levine, Steven L, Tan, Jianguo, Mueller, Geoffrey M, Bachman, Pamela M, Jensen, Peter D, Uffman, Joshua P

“…In recent years, corn rootworm (CRW)-resistant maize events producing two or more CRW-active Bt proteins have been commercialized to enhance efficacy against…”
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WHO/IUIS Allergen Nomenclature: Providing a common language by Pomés, Anna, Davies, Janet M., Gadermaier, Gabriele, Hilger, Christiane, Holzhauser, Thomas, Lidholm, Jonas, Lopata, Andreas L., Mueller, Geoffrey A., Nandy, Andreas, Radauer, Christian, Chan, Sanny K., Jappe, Uta, Kleine-Tebbe, Jörg, Thomas, Wayne R., Chapman, Martin D., van Hage, Marianne, van Ree, Ronald, Vieths, Stefan, Raulf, Monika, Goodman, Richard E.

“…•Beginning and evolution of the official Allergen Nomenclature system 1980–2018.•Allergen Names abbreviated genus, species and number.•Expected data including…”
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New Insights into Cockroach Allergens by Pomés, Anna, Mueller, Geoffrey A., Randall, Thomas A., Chapman, Martin D., Arruda, L. Karla

“…Purpose of Review This review addresses the most recent developments on cockroach allergen research in relation to allergic diseases, especially asthma. Recent…”
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A synergistic approach to protein crystallization: Combination of a fixed‐arm carrier with surface entropy reduction by Moon, Andrea F., Mueller, Geoffrey A., Zhong, Xuejun, Pedersen, Lars C.

“…Protein crystallographers are often confronted with recalcitrant proteins not readily crystallizable, or which crystallize in problematic forms. A variety of…”
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Non-targeted chemical analysis of consumer botanical products labeled as blue cohosh (Caulophyllum thalictroides), goldenseal (Hydrastis canadensis), or yohimbe bark (Pausinystalia yohimbe) by NMR and MS by Quiroz-Delfi, Giovanni O., Rider, Cynthia V., Ferguson, Stephen S., Jarmusch, Alan K., Mueller, Geoffrey A.

“…Consumers have unprecedented access to botanical dietary supplements through online retailers, making it difficult to ensure product quality and authenticity…”
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Neutralizing IgG4 antibodies are a biomarker of sustained efficacy after peanut oral immunotherapy by Keswani, Tarun, LaHood, Nicole A., Marini-Rapoport, Orlee, Karmakar, Bijoya, Andrieux, Léna, Reese, Brian, Sneed, Sunny L., Pedersen, Lars C., Mueller, Geoffrey A., Patil, Sarita U.

“…[Display omitted] Clinical efficacy of oral immunotherapy (OIT) has been associated with the induction of blocking antibodies, particularly those capable of…”
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Defining the cross-reactivity between peanut allergens Ara h 2 and Ara h 6 using monoclonal antibodies by Marini-Rapoport, Orlee, Fernández-Quintero, Monica L, Keswani, Tarun, Zong, Guangning, Shim, Jane, Pedersen, Lars C, Mueller, Geoffrey A, Patil, Sarita U

“…In peanut allergy, Arachis hypogaea 2 (Ara h 2) and Arachis hypogaea 6 (Ara h 6) are two clinically relevant peanut allergens with known structural and…”
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