Search Results - "Mueller, Frank U."

Upregulation of SERCA2a following short-term ACE inhibition (by enalaprilat) alters contractile performance and arrhythmogenicity of healthy myocardium in rat by Matus, Marek, Kucerova, Dana, Kruzliak, Peter, Adameova, Adriana, Doka, Gabriel, Turcekova, Katarina, Kmecova, Jana, Kyselovic, Jan, Krenek, Peter, Kirchhefer, Uwe, Mueller, Frank U., Boknik, Peter, Klimas, Jan

“…Chronic angiotensin-converting enzyme inhibitor (ACEIs) treatment can suppress arrhythmogenesis. To examine whether the effect is more immediate and…”
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Tropisetron suppresses collagen synthesis in skin fibroblasts via [alpha]7 nicotinic acetylcholine receptor and attenuates fibrosis in a scleroderma mouse model by Stegemann, Agatha, Sindrilaru, Anca, Eckes, Beate, del Rey, Adriana, Heinick, Alexander, Schulte, Jan S, Müller, Frank U, Grando, Sergei A, Fiebich, Bernd L, Scharffetter-Kochanek, Karin, Luger, Thomas A, Böhm, Markus

“…Objective There is increasing evidence that serotonin (5-hydroxytryptamine [5-HT]) and distinct 5-HT receptors are involved in the pathogenesis of systemic…”
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Enhanced Cardiomyocyte NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation by Yao, Chunxia, Veleva, Tina, Scott, Larry, Cao, Shuyi, Li, Luge, Chen, Gong, Jeyabal, Prince, Pan, Xiaolu, Alsina, Katherina M, Abu-Taha, Issam, Ghezelbash, Shokoufeh, Reynolds, Corey L, Shen, Ying H, LeMaire, Scott A, Schmitz, Wilhelm, Müller, Frank U, El-Armouche, Ali, Tony Eissa, N, Beeton, Christine, Nattel, Stanley, Wehrens, Xander H.T, Dobrev, Dobromir, Li, Na

“…BACKGROUND:Atrial fibrillation (AF) is frequently associated with enhanced inflammatory response. The NLRP3 (NACHT, LRR, and PYD domain containing protein 3)…”
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Learning, Teamwork and Appropriability: Managing Technological Change in the Department of Social Security by Dyerson, Romano, Mueller, Frank U.

“…Drawing on an extensive case study, we argue that management has to actively manage information flows, both within the organization and between the…”
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Annexin A4 N‐terminal peptide inhibits adenylyl cyclase 5 and limits β‐adrenoceptor‐mediated prolongation of cardiac action potential by Heinick, Alexander, Pluteanu, Florentina, Hermes, Christina, Klemme, Andre, Domnik, Manuel, Husser, Xenia, Gerke, Volker, Schmitz, Wilhelm, Müller, Frank U.

“…Adenylyl cyclases (AC) are essential for the normal and pathophysiological response of many cells. In cardiomyocytes, the predominant AC isoforms are AC5 and…”
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Ryanodine Receptor–Mediated Calcium Leak Drives Progressive Development of an Atrial Fibrillation Substrate in a Transgenic Mouse Model by Li, Na, Chiang, David Y, Wang, Sufen, Wang, Qiongling, Sun, Liang, Voigt, Niels, Respress, Jonathan L, Ather, Sameer, Skapura, Darlene G, Jordan, Valerie K, Horrigan, Frank T, Schmitz, Wilhelm, Müller, Frank U, Valderrabano, Miguel, Nattel, Stanley, Dobrev, Dobromir, Wehrens, Xander H.T

“…BACKGROUND—The progression of atrial fibrillation (AF) from paroxysmal to persistent forms remains a major clinical challenge. Abnormal sarcoplasmic reticulum…”
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Impaired myocellular Ca2+ cycling in protein phosphatase PP2A-B56α KO mice is normalized by β-adrenergic stimulation by Glaser, Dennis, Heinick, Alexander, Herting, Julius R., Massing, Fabian, Müller, Frank U., Pauls, Paul, Rozhdestvensky, Timofey S., Schulte, Jan S., Seidl, Matthias D., Skryabin, Boris V., Stümpel, Frank, Kirchhefer, Uwe

“…The activity of protein phosphatase 2A (PP2A) is determined by the expression and localization of the regulatory B-subunits. PP2A-B56α is the dominant isoform…”
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An improved reporter identifies ruxolitinib as a potent and cardioprotective CaMKII inhibitor by Reyes Gaido, Oscar E, Pavlaki, Nikoleta, Granger, Jonathan M, Mesubi, Olurotimi O, Liu, Bian, Lin, Brian L, Long, Alan, Walker, David, Mayourian, Joshua, Schole, Kate L, Terrillion, Chantelle E, Nkashama, Lubika J, Hulsurkar, Mohit M, Dorn, Lauren E, Ferrero, Kimberly M, Huganir, Richard L, Müller, Frank U, Wehrens, Xander H T, Liu, Jun O, Luczak, Elizabeth D, Bezzerides, Vassilios J, Anderson, Mark E

“…Ca /calmodulin-dependent protein kinase II (CaMKII) hyperactivity causes cardiac arrhythmias, a major source of morbidity and mortality worldwide. Despite…”
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Chronic β-adrenergic stimulation reverses depressed Ca handling in mice overexpressing inhibitor-2 of protein phosphatase 1 by Kirchhefer, Uwe, Hammer, Elke, Heinick, Alexander, Herpertz, Thomas, Isensee, Gunnar, Müller, Frank U., Neumann, Joachim, Schulte, Kirsten, Seidl, Matthias D., Boknik, Peter, Schulte, Jan S.

“…A higher expression/activity of type 1 serine/threonine protein phosphatase 1 (PP1) may contribute to dephosphorylation of cardiac regulatory proteins…”
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Cardiac Function Is Regulated by B56α-mediated Targeting of Protein Phosphatase 2A (PP2A) to Contractile Relevant Substrates by Kirchhefer, Uwe, Brekle, Christiane, Eskandar, John, Isensee, Gunnar, Kučerová, Dana, Müller, Frank U., Pinet, Florence, Schulte, Jan S., Seidl, Matthias D., Boknik, Peter

“…Dephosphorylation of important myocardial proteins is regulated by protein phosphatase 2A (PP2A), representing a heterotrimer that is comprised of catalytic,…”
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Induction of ICER is superseded by smICER, challenging the impact of ICER under chronic beta‐adrenergic stimulation by Seidl, Matthias D., Fels, Benedikt, Kranick, Daniel, Sternberg, Alexandra, Grimm, Kristina, Stümpel, Frank T., Pluteanu, Florentina, Schulte, Jan S., Heinick, Alexander, Kojima, Nobuhiko, Endo, Shogo, Huge, Andreas, Stoll, Monika, Müller, Frank U.

“…ICER (inducible cAMP early repressor) isoforms are transcriptional repressors encoded by the Crem (cAMP responsive element modulator) gene. They were linked to…”
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A novel isoform of myosin 18A (Myo18Aγ) is an essential sarcomeric protein in mouse heart by Horsthemke, Markus, Nutter, Lauryl M.J., Bachg, Anne C., Skryabin, Boris V., Honnert, Ulrike, Zobel, Thomas, Bogdan, Sven, Stoll, Monika, Seidl, Matthias D., Müller, Frank U., Ravens, Ursula, Unger, Andreas, Linke, Wolfgang A., van Gorp, Pim R.R., de Vries, Antoine A.F., Bähler, Martin, Hanley, Peter J.

“…Whereas myosin 18B (Myo18B) is known to be a critical sarcomeric protein, the function of myosin 18A (Myo18A) is unclear, although it has been implicated in…”
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Annexin A4 is a novel direct regulator of adenylyl cyclase type 5 by Heinick, Alexander, Husser, Xenia, Himmler, Kirsten, Kirchhefer, Uwe, Nunes, Frank, Schulte, Jan S., Seidl, Matthias D., Rolfes, Christina, Dedman, John R., Kaetzel, Marcia A., Gerke, Volker, Schmitz, Wilhelm, Müller, Frank U.

“…ABSTRACT Annexin A4 (AnxA4), a Ca2+‐ and phospholipid‐binding protein, is up‐regulated in the human failing heart In this study, we examined the impact of…”
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Successful overexpression of wild-type inhibitor-2 of PP1 in cardiovascular cells by Krause, Thorsten, Grote-Wessels, Stefanie, Balzer, Felix, Boknik, Peter, Gergs, Ulrich, Kirchhefer, Uwe, Buchwalow, Igor B., Müller, Frank U., Schmitz, Wilhelm, Neumann, Joachim

“…About half of the cardiac serine/threonine phosphatase activity is due to the activity of protein phosphatase type 1 (PP1). The activity of PP1 can be…”
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Characterization of the Genetic Program Linked to the Development of Atrial Fibrillation in CREM-IbΔC-X Mice by Seidl, Matthias D, Stein, Juliane, Hamer, Sabine, Pluteanu, Florentina, Scholz, Beatrix, Wardelmann, Eva, Huge, Andreas, Witten, Anika, Stoll, Monika, Hammer, Elke, Völker, Uwe, Müller, Frank U

“…BACKGROUND—Reduced expression of genes regulated by the transcription factors CREB/CREM (cAMP response element-binding protein/modulator) is linked to atrial…”
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Inward Rectifier K + Currents Contribute to the Proarrhythmic Electrical Phenotype of Atria Overexpressing Cyclic Adenosine Monophosphate Response Element Modulator Isoform CREM-IbΔC-X by Pluteanu, Florentina, Seidl, Matthias D, Hamer, Sabine, Scholz, Beatrix, Müller, Frank U

“…BACKGROUND Transgenic mice (TG) with heart-directed overexpresion of the isoform of the transcription factor cyclic adenosine monophosphate response element…”
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Profiling of histone H3 lysine 9 trimethylation levels predicts transcription factor activity and survival in acute myeloid leukemia by Müller-Tidow, Carsten, Klein, Hans-Ulrich, Hascher, Antje, Isken, Fabienne, Tickenbrock, Lara, Thoennissen, Nils, Agrawal-Singh, Shuchi, Tschanter, Petra, Disselhoff, Christine, Wang, Yipeng, Becker, Anke, Thiede, Christian, Ehninger, Gerhard, zur Stadt, Udo, Koschmieder, Steffen, Seidl, Matthias, Müller, Frank U., Schmitz, Wilhelm, Schlenke, Peter, McClelland, Michael, Berdel, Wolfgang E., Dugas, Martin, Serve, Hubert

“…Acute myeloid leukemia (AML) is commonly associated with alterations in transcription factors because of altered expression or gene mutations. These changes…”
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Suppression of Early and Late Afterdepolarizations by Heterozygous Knockout of the Na+/Ca2+ Exchanger in a Murine Model by Bögeholz, Nils, Pauls, Paul, Bauer, B Klemens, Schulte, Jan S, Dechering, Dirk G, Frommeyer, Gerrit, Kirchhefer, Uwe, Goldhaber, Joshua I, Müller, Frank U, Eckardt, Lars, Pott, Christian

“…The Na(+)/Ca(2+) exchanger (NCX) has been implied to cause arrhythmias. To date, information on the role of NCX in arrhythmogenesis derived from models with…”
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Increased in vivo perpetuation of whole-heart ventricular arrhythmia in heterozygous Na+/Ca2+ exchanger knockout mice by Bögeholz, Nils, Knappe, Vincent, Pauls, Paul, Schulte, Jan S., Goldhaber, Joshua I., Müller, Frank U., Nickenig, Georg, Eckardt, Lars, Schrickel, Jan W., Beiert, Thomas

“…Na+/Ca2+ exchanger (NCX) upregulation in cardiac diseases like heart failure promotes as an independent proarrhythmic factor early and delayed…”
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Initial Characterization of Stressed Transgenic Mice With Cardiomyocyte-Specific Overexpression of Protein Phosphatase 2C by Bollmann, Paula, Werner, Franziska, Jaron, Marko, Bruns, Tom A, Wache, Hartmut, Runte, Jochen, Boknik, Peter, Kirchhefer, Uwe, Müller, Frank U, Buchwalow, Igor B, Rothemund, Sven, Neumann, Joachim, Gergs, Ulrich

“…As part of our ongoing studies on the potential pathophysiological role of serine/threonine phosphatases (PP) in the mammalian heart, we have generated mice…”
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