Search Results - "Mueller, Bernhard K"

RGMs: Structural Insights, Molecular Regulation, and Downstream Signaling by Siebold, Christian, Yamashita, Toshihide, Monnier, Philippe P, Mueller, Bernhard K, Pasterkamp, R. Jeroen

“…Although originally discovered as neuronal growth cone-collapsing factors, repulsive guidance molecules (RGMs) are now known as key players in many fundamental…”
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Delayed administration of the human anti-RGMa monoclonal antibody elezanumab promotes functional recovery including spontaneous voiding after spinal cord injury in rats by Mothe, Andrea J., Coelho, Marlon, Huang, Lili, Monnier, Philippe P., Cui, Yi-Fang, Mueller, Bernhard K., Jacobson, Peer B., Tator, Charles H.

“…Spinal cord injury (SCI) often results in permanent functional loss due to a series of degenerative events including cell death, axonal damage, and the…”
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Elezanumab, a human anti-RGMa monoclonal antibody, promotes neuroprotection, neuroplasticity, and neurorecovery following a thoracic hemicompression spinal cord injury in non-human primates by Jacobson, Peer B., Goody, Robin, Lawrence, Matthew, Mueller, Bernhard K., Zhang, Xiaomeng, Hooker, Bradley A., Pfleeger, Kimberly, Ziemann, Adam, Locke, Charles, Barraud, Quentin, Droescher, Mathias, Bernhard, Joerg, Popp, Andreas, Boeser, Preethne, Huang, Lili, Mollon, Jennifer, Mordashova, Yulia, Cui, Yi-Fang, Savaryn, John P., Grinnell, Christine, Dreher, Ingeborg, Gold, Michael, Courtine, Grégoire, Mothe, Andrea, Tator, Charles H., Guest, James D.

“…Spinal cord injury (SCI) is a devastating condition characterized by loss of function, secondary to damaged spinal neurons, disrupted axonal connections, and…”
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Elezanumab, a clinical stage human monoclonal antibody that selectively targets repulsive guidance molecule A to promote neuroregeneration and neuroprotection in neuronal injury and demyelination models by Huang, Lili, Fung, Emma, Bose, Sahana, Popp, Andreas, Böser, Preethne, Memmott, John, Kutskova, Yuliya A., Miller, Renee, Tarcsa, Edit, Klein, Corinna, Veldman, Geertruida M., Mueller, Bernhard K., Cui, Yi-Fang

“…Repulsive guidance molecule A (RGMa) is a potent inhibitor of axonal growth and a regulator of neuronal cell death. It is up-regulated following neuronal…”
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The liver and muscle secreted HFE2-protein maintains central nervous system blood vessel integrity by Wang, Xue Fan, Vigouroux, Robin, Syonov, Michal, Baglaenko, Yuriy, Nikolakopoulou, Angeliki M., Ringuette, Dene, Rus, Horea, DiStefano, Peter V., Dufour, Suzie, Shabanzadeh, Alireza P., Lee, Seunggi, Mueller, Bernhard K., Charish, Jason, Harada, Hidekiyo, Fish, Jason E., Wither, Joan, Wälchli, Thomas, Cloutier, Jean-François, Zlokovic, Berislav V., Carlen, Peter L., Monnier, Philippe P.

“…Liver failure causes breakdown of the Blood CNS Barrier (BCB) leading to damages of the Central-Nervous-System (CNS), however the mechanisms whereby the liver…”
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Rho kinase inhibition modulates microglia activation and improves survival in a model of amyotrophic lateral sclerosis by Tönges, Lars, Günther, Rene, Suhr, Martin, Jansen, Johannes, Balck, Alexander, Saal, Kim-Ann, Barski, Elisabeth, Nientied, Tobias, Götz, Alexander A., Koch, Jan-Christoph, Mueller, Bernhard K., Weishaupt, Jochen H., Sereda, Michael W., Hanisch, Uwe-Karsten, Bähr, Mathias, Lingor, Paul

“…Disease progression in amyotrophic lateral sclerosis (ALS) is characterized by degeneration of motoneurons (MN) and their axons, but is also influenced by…”
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Targeting Repulsive Guidance Molecule A to Promote Regeneration and Neuroprotection in Multiple Sclerosis by Demicheva, Elena, Cui, Yi-Fang, Bardwell, Philip, Barghorn, Stefan, Kron, Martina, Meyer, Axel H., Schmidt, Martin, Gerlach, Björn, Leddy, Mary, Barlow, Eve, O’Connor, Elizabeth, Choi, Chee-Ho, Huang, Lili, Veldman, Geertruida M., Rus, Horea, Shabanzadeh, Alireza P., Tassew, Nardos G., Monnier, Philippe P., Müller, Thomas, Calabresi, Peter A., Schoemaker, Hans, Mueller, Bernhard K.

“…Repulsive guidance molecule A (RGMa) is a potent inhibitor of neuronal regeneration and a regulator of cell death, and it plays a role in multiple sclerosis…”
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Anti-hemojuvelin antibody corrects anemia caused by inappropriately high hepcidin levels by Kovac, Suzana, Böser, Preethne, Cui, Yifang, Ferring-Appel, Dunja, Casarrubea, Daniela, Huang, Lili, Fung, Emma, Popp, Andreas, Mueller, Bernhard K, Hentze, Matthias W

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RGMa inhibition promotes axonal growth and recovery after spinal cord injury by Hata, Katsuhiko, Fujitani, Masashi, Yasuda, Yuichi, Doya, Hideo, Saito, Tomoko, Yamagishi, Satoru, Mueller, Bernhard K, Yamashita, Toshihide

“…Repulsive guidance molecule (RGM) is a protein implicated in both axonal guidance and neural tube closure. We report RGMa as a potent inhibitor of axon…”
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Growth cone guidance : First steps towards a deeper understanding by MUELLER, B. K

“…Growth cones, the hand-like structures at the tip of growing neurites, possess remarkable abilities to detect directional cues. On their way to their targets…”
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RGM and its receptor neogenin regulate neuronal survival by Chédotal, Alain, Matsunaga, Eiji, Tauszig-Delamasure, Servane, Monnier, Philippe P, Mueller, Bernhard K, Strittmatter, Stephen M, Mehlen, Patrick

“…Repulsive guidance molecule (RGM) is an axon guidance protein that repels retinal axons upon activation of the neogenin receptor. To understand the functions…”
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Stimulating neuroregeneration as a therapeutic drug approach for traumatic brain injury by Mueller, Bernhard K, Mueller, Reinhold, Schoemaker, Hans

“…Traumatic brain injury, a silent epidemic of modern societies, is a largely neglected area in drug development and no drug is currently available for the…”
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Ephrin-A5 Induces Collapse of Growth Cones by Activating Rho and Rho Kinase by Wahl, Siegfried, Barth, Holger, Ciossek, Thomas, Aktories, Klaus, Mueller, Bernhard K.

“…The ephrins, ligands of Eph receptor tyrosine kinases, have been shown to act as repulsive guidance molecules and to induce collapse of neuronal growth cones…”
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Myosin IIA is required for neurite outgrowth inhibition produced by repulsive guidance molecule by Kubo, Takekazu, Endo, Mitsuharu, Hata, Katsuhiko, Taniguchi, Junko, Kitajo, Keiko, Tomura, Sayaka, Yamaguchi, Atsushi, Mueller, Bernhard K, Yamashita, Toshihide

“…Although myelin-associated neurite outgrowth inhibitors express their effects through RhoA/Rho-kinase, the downstream targets of Rho-kinase remain unknown. We…”
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Spinal cord injury-induced lesional expression of the repulsive guidance molecule (RGM) by Schwab, Jan M., Conrad, Sabine, Monnier, Philippe P., Julien, Sylvie, Mueller, Bernhard K., Schluesener, Hermann J.

“…The repulsive guidance molecule (RGM) is involved in the formation of the central nervous system (CNS) during development by modulating guidance of growing…”
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The role of repulsive guidance molecules in the embryonic and adult vertebrate central nervous system by Mueller, Bernhard K, Yamashita, Toshihide, Schaffar, Gregor, Mueller, Reinhold

“…During the development of the nervous system, outgrowing axons often have to travel long distances to reach their target neurons. In this process, outgrowing…”
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The Repulsive Guidance Molecule RGMa Is Involved in the Formation of Afferent Connections in the Dentate Gyrus by Brinks, Henriette, Conrad, Sabine, Vogt, Johannes, Oldekamp, Judit, Sierra, Ana, Deitinghoff, Lutz, Bechmann, Ingo, Alvarez-Bolado, Gonzalo, Heimrich, Bernd, Monnier, Philippe P, Mueller, Bernhard K, Skutella, Thomas

“…In the developing dentate gyrus, afferent fiber projections terminate in distinct laminas. This relies on an accurately regulated spatiotemporal network of…”
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Rho kinase, a promising drug target for neurological disorders by Mueller, Bernhard K, Mack, Helmut, Teusch, Nicole

“…Rho kinases (ROCKs), the first Rho effectors to be described, are serine/threonine kinases that are important in fundamental processes of cell migration, cell…”
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Levodopa increases oxidative stress and repulsive guidance molecule A levels: a pilot study in patients with Parkinson’s disease by Müller, Thomas, Trommer, Isabel, Muhlack, Siegfried, Mueller, Bernhard K.

“…Exposure to free radicals influences synthesis, degradation and function of proteins, such as repulsive guidance molecule A. Decay of this protein is essential…”
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RGMa inhibition with human monoclonal antibodies promotes regeneration, plasticity and repair, and attenuates neuropathic pain after spinal cord injury by Mothe, Andrea J., Tassew, Nardos G., Shabanzadeh, Alirezha P., Penheiro, Romeo, Vigouroux, Robin J., Huang, Lili, Grinnell, Christine, Cui, Yi-Fang, Fung, Emma, Monnier, Philippe P., Mueller, Bernhard K., Tator, Charles H.

“…Traumatic spinal cord injury (SCI) causes a cascade of degenerative events including cell death, axonal damage, and the upregulation of inhibitory molecules…”
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