Search Results - "Mueller, Beatrice"

Complexity of CEBPA Dysregulation in Human Acute Myeloid Leukemia by PABST, Thomas, MUELLER, Beatrice U

“…The transcription factor CCAAT enhancer binding protein alpha (CEBPA) is crucial for normal development of granulocytes. Various mechanisms have been…”
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Autologous Transplantation for Older Adults with AML by Mueller, Beatrice U, Seipel, Katja, Bacher, Ulrike, Pabst, Thomas

“…While the majority of patients with acute myeloid leukemia (AML) are above the age of 65 years at diagnosis, the outcome of older AML patients remains…”
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Somatic CEBPA Mutations Are a Frequent Second Event in Families With Germline CEBPA Mutations and Familial Acute Myeloid Leukemia by PABST, Thomas, EYHOLZER, Marianne, HAEFLIGER, Simon, SCHARDT, Julian, MUELLER, Beatrice U

“…The transcription factor CCAAT/enhancer binding protein-alpha (CEBPA) is crucial for normal myeloid differentiation. Mutations in the CEBPA gene are found in…”
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MDM2- and FLT3-inhibitors in the treatment of FLT3 -ITD acute myeloid leukemia, specificity and efficacy of NVP-HDM201 and midostaurin by Seipel, Katja, Marques, Miguel A T, Sidler, Corinne, Mueller, Beatrice U, Pabst, Thomas

“…Prognosis for -ITD positive acute myeloid leukemia with high allelic ratio (>0.5) is poor, particularly in relapse, refractory to or unfit for intensive…”
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The Cellular p53 Inhibitor MDM2 and the Growth Factor Receptor FLT3 as Biomarkers for Treatment Responses to the MDM2-Inhibitor Idasanutlin and the MEK1 Inhibitor Cobimetinib in Acute Myeloid Leukemia by Seipel, Katja, Marques, Miguel A T, Sidler, Corinne, Mueller, Beatrice U, Pabst, Thomas

“…The tumor suppressor protein p53 is inactivated in a large variety of cancer cells. Cellular p53 inhibitors like the mouse double minute 2 homolog (MDM2)…”
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Inactivation of the p53-KLF4-CEBPA Axis in Acute Myeloid Leukemia by Seipel, Katja, Marques, Miguel Teixera, Bozzini, Marie-Ange, Meinken, Christina, Mueller, Beatrice U, Pabst, Thomas

“…In acute myeloid leukemia (AML), the transcription factors CEBPA and KLF4 as well as the universal tumor suppressor p53 are frequently deregulated. Here, we…”
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Component periods of non-principal-axis rotation and their manifestations in the lightcurves of asteroids and bare cometary nuclei by Samarasinha, Nalin H., Mueller, Beatrice E.A.

“…•Lightcurves were simulated for known non-principal-axis (NPA) rotations.•Lightcurves were analyzed to determine which periodicity signatures are…”
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Myelodysplastic syndromes and acute myeloid leukemias in the elderly by Mueller, Beatrice U., Seipel, Katja, Pabst, Thomas

“…Most patients above 60 years with acute myeloid leukemia (AML) will die from their disease. Nevertheless, the treatment concepts in elderly patients with…”
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Unmet challenges in treating hypertension in patients with borderline personality disorder: A systematic review by Roininen, Saara M., Cheetham, Marcus, Mueller, Beatrice U., Battegay, Edouard

“…Caregivers encounter serious and substantial challenges in managing hypertension in patients with subclinical or clinical borderline personality disorder…”
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Analysis of R-band observations of an outburst of Comet 29P/Schwassmann-Wachmann 1 to place constraints on the nucleus’ rotation state by Schambeau, Charles A., Fernández, Yanga R., Samarasinha, Nalin H., Mueller, Beatrice E.A., Woodney, Laura M.

“…•Five consecutive nights of observations of SW1  4 days after a major outburst were analyzed.•An expanding shell of material was measured to have a projected…”
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The maximum alcohol withdrawal syndrome score associates with worse clinical outcomes—A retrospective cohort study by Griessbach, Alexandra N., Mueller, Beatrice U., Battegay, Edouard, Beeler, Patrick E.

“…•Maximum alcohol withdrawal syndrome (AWS) score is higher in multimorbid patients.•Higher maximum AWS scores associate with worse outcomes (length of…”
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Iron overload is correlated with impaired autologous stem cell mobilization and survival in acute myeloid leukemia by Alva, Laura C., Bacher, Ulrike, Seipel, Katja, Mansouri Taleghani, Behrouz, Mueller, Beatrice U., Novak, Urban, Pabst, Thomas

“…BACKGROUND Patients with acute myeloid leukemia (AML) undergoing consolidation with autologous stem cell transplantation (ASCT) depend on the successful…”
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Improved survival rates of AML patients following admission to the intensive care unit by Fassbind, Priska, Jeker, Barbara, Mueller, Beatrice U., Bacher, Ulrike, Zimmerli, Stefan, Endrich, Olga, Gahl, Brigitta, Novak, Urban, Pabst, Thomas

“…Induction chemotherapy in AML patients may have life-threatening side effects requiring intensive care unit (ICU) treatment. We analyzed all AML patients…”
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Adverse outcome of AML with aberrant CD16 and CD56 NK cell marker expression by Junge, Alexandra, Bacher, Ulrike, Mueller, Beatrice U., Keller, Peter, Solenthaler, Max, Pabst, Thomas

“…Natural killer cells mediate antibody‐dependent cell‐mediated cytotoxicity, and CD16 exerts key functions to induce antibody‐dependent cell‐mediated…”
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Protein disulfide isomerase blocks CEBPA translation and is up-regulated during the unfolded protein response in AML by Haefliger, Simon, Klebig, Christiane, Schaubitzer, Kerstin, Schardt, Julian, Timchenko, Nikolai, Mueller, Beatrice U., Pabst, Thomas

“…Deregulation of the myeloid key transcription factor CEBPA is a common event in acute myeloid leukemia (AML). We previously reported that the chaperone…”
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Heterozygous deletion of the PU.1 locus in human AML by Bonadies, Nicola, Pabst, Thomas, Mueller, Beatrice U.

“…The transcription factor PU.1 is essential for myeloid development. Targeted disruption of an upstream regulatory element (URE) decreases PU.1 expression by…”
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A randomized evaluation of vinorelbine versus gemcitabine chemotherapy mobilization of stem cells in myeloma patients by Jeker, Barbara, Farag, Sarah, Taleghani, Behrouz Mansouri, Novak, Urban, Mueller, Beatrice U., Li, Qiyu, Betticher, Daniel, Luethi, Jean-Marc, Farese, Simone, Ruefer, Axel, Bacher, Ulrike, Pabst, Thomas

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Pharmacokinetics, Safety, Tolerability, and Pharmacodynamics of Alicapistat, a Selective Inhibitor of Human Calpains 1 and 2 for the Treatment of Alzheimer Disease: An Overview of Phase 1 Studies by Lon, Hoi‐Kei, Mendonca, Nuno, Goss, Sandra, Othman, Ahmed A., Locke, Charles, Jin, Ziyi, Rendenbach‐Mueller, Beatrice

“…Alicapistat is an orally active selective inhibitor of calpain 1 and 2 whose overactivation has been linked to Alzheimer disease (AD). Three studies were…”
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Peripheral flow-MRD status at the time of autologous stem cell collection predicts outcome in multiple myeloma by Moor, Ivana, Bacher, Vera U., Jeker, Barbara, Taleghani, Behrouz Mansouri, Mueller, Beatrice U., Keller, Peter, Betticher, Daniel, Egger, Thomas, Novak, Urban, Pabst, Thomas

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The angiogenesis inhibitor vasostatin is regulated by neutrophil elastase–dependent cleavage of calreticulin in AML patients by Mans, Sarah, Banz, Yara, Mueller, Beatrice U., Pabst, Thomas

“…The calcium-binding protein calreticulin (CRT) regulates protein folding in the endoplasmic reticulum (ER) and is induced in acute myeloid leukemia (AML) cells…”
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