Search Results - "Mueller, Amber"

Why does COVID-19 disproportionately affect older people? by Mueller, Amber L, McNamara, Maeve S, Sinclair, David A

“…The severity and outcome of coronavirus disease 2019 (COVID-19) largely depends on a patient's age. Adults over 65 years of age represent 80% of…”
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Skeletal muscle cell transplantation: models and methods by Mueller, Amber L., Bloch, Robert J.

“…Xenografts of skeletal muscle are used to study muscle repair and regeneration, mechanisms of muscular dystrophies, and potential cell therapies for…”
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Novel feature selection methods for construction of accurate epigenetic clocks by Li, Adam, Mueller, Amber, English, Brad, Arena, Anthony, Vera, Daniel, Kane, Alice E, Sinclair, David A

“…Epigenetic clocks allow us to accurately predict the age and future health of individuals based on the methylation status of specific CpG sites in the genome…”
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Optimization of Xenografting Methods for Generating Human Skeletal Muscle in Mice by O'Neill, Andrea, Martinez, Anna Llach, Mueller, Amber L, Huang, Weiliang, Accorsi, Anthony, Kane, Maureen A, Eyerman, David, Bloch, Robert J

“…Xenografts of human skeletal muscle generated in mice can be used to study muscle pathology and to test drugs designed to treat myopathies and muscular…”
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Dysferlin stabilizes stress-induced Ca²⁺ signaling in the transverse tubule membrane by Kerr, Jaclyn P., Ziman, Andrew P., Mueller, Amber L., Muriel, Joaquin M., Kleinhans-Welte, Emily, Gumerson, Jessica D., Vogel, Steven S., Ward, Christopher W., Roche, Joseph A., Bloch, Robert J.

“…Dysferlinopathies, most commonly limb girdle muscular dystrophy 2B and Miyoshi myopathy, are degenerative myopathies caused by mutations in the DYSF gene…”
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Muscle xenografts reproduce key molecular features of facioscapulohumeral muscular dystrophy by Mueller, Amber L., O'Neill, Andrea, Jones, Takako I., Llach, Anna, Rojas, Luis Alejandro, Sakellariou, Paraskevi, Stadler, Guido, Wright, Woodring E., Eyerman, David, Jones, Peter L., Bloch, Robert J.

“…Aberrant expression of DUX4, a gene unique to humans and primates, causes Facioscapulohumeral Muscular Dystrophy-1 (FSHD), yet the pathogenic mechanism is…”
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Regulatory T cells shield muscle mitochondria from interferon-γ-mediated damage to promote the beneficial effects of exercise by Langston, P Kent, Sun, Yizhi, Ryback, Birgitta A, Mueller, Amber L, Spiegelman, Bruce M, Benoist, Christophe, Mathis, Diane

“…Exercise enhances physical performance and reduces the risk of many disorders such as cardiovascular disease, type 2 diabetes, dementia, and cancer. Exercise…”
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Myofiber Damage Precedes Macrophage Infiltration after in Vivo Injury in Dysferlin-Deficient A/J Mouse Skeletal Muscle by Roche, Joseph A, Tulapurkar, Mohan E, Mueller, Amber L, van Rooijen, Nico, Hasday, Jeffrey D, Lovering, Richard M, Bloch, Robert J

“…Mutations in the dysferlin gene ( DYSF ) lead to human muscular dystrophies known as dysferlinopathies. The dysferlin-deficient A/J mouse develops a mild…”
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Sex dimorphism and tissue specificity of gene expression changes in aging mice by Zhu, Dantong, Arnold, Matt, Samuelson, Brady A, Wu, Judy Z, Mueller, Amber, Sinclair, David A, Kane, Alice E

“…Aging is a complex process that involves all tissues in an organism and shows sex dimorphism. While transcriptional changes in aging have been well…”
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Sodium 4-phenylbutyrate reduces myofiber damage in a mouse model of Duchenne muscular dystrophy by Begam, Morium, Abro, Valerie M, Mueller, Amber L, Roche, Joseph A

“…We performed a placebo-controlled pre-clinical study to determine if sodium 4-phenylbutyrate (4PB) can reduce contraction-induced myofiber damage in the mdx…”
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TIME-seq reduces time and cost of DNA methylation measurement for epigenetic clock construction by Griffin, Patrick T, Kane, Alice E, Trapp, Alexandre, Li, Jien, Arnold, Matthew, Poganik, Jesse R, Conway, Ryan J, McNamara, Maeve S, Meer, Margarita V, Hoffman, Noah, Amorim, João A, Tian, Xiao, MacArthur, Michael R, Mitchell, Sarah J, Mueller, Amber L, Carmody, Colleen, Vera, Daniel L, Kerepesi, Csaba, Ying, Kejun, Noren Hooten, Nicole, Mitchell, James R, Evans, Michele K, Gladyshev, Vadim N, Sinclair, David A

“…Epigenetic 'clocks' based on DNA methylation have emerged as the most robust and widely used aging biomarkers, but conventional methods for applying them are…”
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Improved immunoblotting methods provide critical insights into phenotypic differences between two murine dysferlinopathy models by Mueller, Amber L., Desmond, Patrick F., Hsia, Ru-ching, Roche, Joseph A.

“…ABSTRACT Introduction: We adopted a proteomics‐based approach to gain insights into phenotypic differences between A/J and B10.SJL murine dysferlinopathy…”
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Diltiazem improves contractile properties of skeletal muscle in dysferlin‐deficient BLAJ mice, but does not reduce contraction‐induced muscle damage by Begam, Morium, Collier, Alyssa F., Mueller, Amber L., Roche, Renuka, Galen, Sujay S., Roche, Joseph A.

“…B6.A‐Dysfprmd/GeneJ (BLAJ) mice model human limb‐girdle muscular dystrophy 2B (LGMD2B), which is linked to mutations in the dysferlin (DYSF) gene. We tested…”
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Neuromuscular electrical stimulation promotes development in mice of mature human muscle from immortalized human myoblasts by Sakellariou, Paraskevi, O'Neill, Andrea, Mueller, Amber L, Stadler, Guido, Wright, Woodring E, Roche, Joseph A, Bloch, Robert J

“…Studies of the pathogenic mechanisms underlying human myopathies and muscular dystrophies often require animal models, but models of some human diseases are…”
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Chemical Chaperone Therapy Reduces Myofiber Damage in Dystrophin‐null mdx Mice by Roche, Joseph, Mueller, Amber

“…Abstract only Duchenne Muscular Dystrophy (DMD), which affects approximately 1 in 3600 male children, is associated with the absence of the sarcolemmal protein…”
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The how and when of metabolic health by Mott, Rosalind, Evans, Allyson, Fernandez-Aguera, Mari-Carmen, Mueller, Amber

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Large‐strain In Vivo Lengthening Contractions Induce Mitochondrially‐mediated Apoptosis in Dysferlin‐null Muscle by Roche, Joseph A, Mueller, Amber L, Bloch, Robert J

“…Abstract only…”
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The Muscle Xenograft Model of Facioscapulohumeral Muscular Dystrophy: Development, Optimization, and Novel Applications by Mueller, Amber L

“…Aberrant expression of DUX4 in human muscle causes Facioscapulohumeral Muscular dystrophy (FSHD) which affects about 1 in 8,333 individuals worldwide, yet the…”
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Dysferlin maintains the integrity of transverse tubules and the junctional sarcoplasmic reticulum following contraction‐induced injury by Roche, Joseph A, Resneck, Wendy G, Mueller, Amber L, Bloch, Robert J

“…Abstract only…”
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Dysferlin stabilizes stress-induced Ca^sup 2+^ signaling in the transverse tubule membrane by Kerr, Jaclyn P, Ziman, Andrew P, Mueller, Amber L, Muriel, Joaquin M, Kleinhans-Welte, Emily, Gumerson, Jessica D, Vogel, Steven S, Ward, Christopher W, Roche, Joseph A, Bloch, Robert J

“…Dysferlinopathies, most commonly limb girdle muscular dystrophy 2B and Miyoshi myopathy, are degenerative myopathies caused by mutations in the DYSF gene…”
Get full text