Osteoporosis Remains Constant in Patients with Hemophilia-Long-Term Course in Consideration of Comorbidities

Patients with hemophilia (PWHs) suffer from an increased risk of osteoporosis. Multiple hemophilia and hemophilic arthropathy associated factors correlate with a low bone mineral density (BMD) in PWHs. The aim of this study was to assess the long-term development of BMD in PWH as well as to analyze...

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Bibliographic Details
Published in:	Hamostaseologie Vol. 43; no. 3; p. 208
Main Authors:	Strauss, Anna C, Muellejans, Pius, Koob, Sebastian, Goldmann, Georg, Pennekamp, Peter H, Wallny, Thomas A, Oldenburg, Johannes, Strauss, Andreas C
Format:	Journal Article
Language:	English
Published:	Germany 01-06-2023
Subjects:	Adult Bone Density Hemophilia A - complications Hemophilia A - epidemiology Humans Osteoporosis - complications Osteoporosis - diagnosis Osteoporosis - epidemiology Retrospective Studies Vitamin D
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Summary:	Patients with hemophilia (PWHs) suffer from an increased risk of osteoporosis. Multiple hemophilia and hemophilic arthropathy associated factors correlate with a low bone mineral density (BMD) in PWHs. The aim of this study was to assess the long-term development of BMD in PWH as well as to analyze potentially influencing factors. A total of 33 adult PWHs were evaluated in a retrospective study. General medical history, specific-hemophilia-associated comorbidities, joint status using the Gilbert score, calcium level, and vitamin D level as well as at least two results of bone density measurements with a minimum range of 10 years per patient were taken into account. The BMD did not change significantly from one point of measurement to the other. A total of 7 (21.2%) cases of osteoporosis and 16 (48.5%) cases of osteopenia were identified. The two following significant correlations could be revealed: the higher the patients' body mass index, the higher their BMD ( = 0.41; = 0.022). Moreover, a high Gilbert score came along with a low BMD ( = -0.546; = 0.003). Even if PWHs frequently suffer from a reduced BMD, our data suggest that their BMD remains constant on a low level in the course of time. A risk factor of osteoporosis often found in PWHs is a vitamin D deficiency and joint destruction. Therefore, a standardized screening of PWHs on BMD reduction by collecting vitamin D blood level and assessing joint status seems appropriate.
ISSN:	2567-5761
DOI:	10.1055/a-1972-8983