Search Results - "Muehlradt, P F"

Intratumoural injection of the toll-like receptor-2 6 agonist 'macrophage-activating lipopeptide-2' in patients with pancreatic carcinoma: a phase I II trial by SCHMIDT, J, WELSCH, T, JÄGER, D, MÜHLRADT, P. F, BÜCHLER, M. W, MÄRTEN, A

“…This phase I/II trial examined safety and efficacy of the toll-like receptor 2/6 agonist MALP-2 in combination with gemcitabine in patients with incompletely…”
Get full text

Lipopolysaccharide Stimulates the MyD88-Independent Pathway and Results in Activation of IFN-Regulatory Factor 3 and the Expression of a Subset of Lipopolysaccharide-Inducible Genes by Kawai, Taro, Takeuchi, Osamu, Fujita, Takashi, Inoue, Jun-ichiro, Muhlradt, Peter F, Sato, Shintaro, Hoshino, Katsuaki, Akira, Shizuo

“…Bacterial lipopolysaccharide (LPS) triggers innate immune responses through Toll-like receptor (TLR) 4, a member of the TLR family that participates in…”
Get full text

Preferentially the R-Stereoisomer of the Mycoplasmal Lipopeptide Macrophage-Activating Lipopeptide-2 Activates Immune Cells Through a Toll-Like Receptor 2- and MyD88-Dependent Signaling Pathway by Takeuchi, O, Kaufmann, A, Grote, K, Kawai, T, Hoshino, K, Morr, M, Muehlradt, P F, Akira, S

“…Mycoplasmas and their membranes are potent activators of macrophages, the active principle being lipoproteins and lipopeptides. Two stereoisomers of the…”
Get full text

Discrimination of bacterial lipoproteins by Toll-like receptor 6 by Takeuchi, Osamu, Kawai, Taro, Mühlradt, Peter F., Morr, Michael, Radolf, Justin D., Zychlinsky, Arturo, Takeda, Kiyoshi, Akira, Shizuo

“…Bacterial lipoproteins (BLP) trigger immune responses via Toll-like receptor 2 (TLR2) and their immunostimulatory properties are attributed to the presence of…”
Get full text

Synergy and Cross-Tolerance Between Toll-Like Receptor (TLR) 2- and TLR4-Mediated Signaling Pathways by Sato, Shintaro, Nomura, Fumiko, Kawai, Taro, Takeuchi, Osamu, Muhlradt, Peter F, Takeda, Kiyoshi, Akira, Shizuo

“…A family of Toll-like receptor (TLR) mediates the cellular response to bacterial cell wall components; murine TLR2 and TLR4 recognize mycoplasmal lipopeptides…”
Get full text

Isolation, structure elucidation, and synthesis of a macrophage stimulatory lipopeptide from Mycoplasma fermentans acting at picomolar concentration by Mühlradt, P F, Kiess, M, Meyer, H, Süssmuth, R, Jung, G

“…Macrophages are typically stimulated by components of microbial cell walls. Surprisingly, cell wall-less mycoplasmas can also very efficiently stimulate…”
Get full text

Monoclonal antibodies against the human lymphocyte differentiation antigen CD 76 bind to gangliosides by Kniep, Bernhard, Mühlradt, Peter F., Dörken, Bernd, Moldenhauer, Gerhard, Vilella, R., Schwartz-Albiez, Reinhard

“…Two monoclonal antibodies, HD 66 and CRIS-4, by which the new CD 76 B-cell-associated cluster was defined, bound to several gangliosides (sialic acid…”
Get full text

The Mycoplasma‐derived lipopeptide MALP‐2 is a potent mucosal adjuvant by Rharbaoui, Faiza, Drabner, Birgit, Borsutzky, Stefan, Winckler, Urte, Morr, Michael, Ensoli, Barbara, Mühlradt, Peter F., Guzmán, Carlos A.

“…The adjuvanticity of MALP‐2, a 2‐kDa synthetic lipopeptide with macrophage‐stimulatory activity, was evaluated in BALB/c mice using β‐galactosidase (β‐gal) as…”
Get full text

Efficient mucosal delivery of the HIV‐1 Tat protein using the synthetic lipopeptide MALP‐2 as adjuvant by Borsutzky, Stefan, Fiorelli, Valeria, Ebensen, Thomas, Tripiciano, Antonella, Rharbaoui, Faiza, Scoglio, Arianna, Link, Claudia, Nappi, Filomena, Morr, Michael, Buttó, Stefano, Cafaro, Aurelio, Mühlradt, Peter F., Ensoli, Barbara, Guzmán, Carlos A.

“…A major requirement for HIV/AIDS research is the development of a mucosal vaccine that stimulates humoral and cell‐mediated immune responses at systemic and…”
Get full text

Toll-Like Receptor 2- and 6-Mediated Stimulation by Macrophage-Activating Lipopeptide 2 Induces Lipopolysaccharide (LPS) Cross Tolerance in Mice, Which Results in Protection from Tumor Necrosis Factor Alpha but in Only Partial Protection from Lethal LPS Doses by DEITERS, Ursula, GUMENSCHEIMER, Marina, GALANOS, Chris, MÜHLRADT, Peter F

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Mycoplasmal Lipopeptide MALP-2 Induces the Chemoattractant Proteins Macrophage Inflammatory Protein 1α (MIP-1α), Monocyte Chemoattractant Protein 1, and MIP-2 and Promotes Leukocyte Infiltration in Mice by Deiters, U, Muehlradt, P F

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

In Vivo Effects of a Synthetic 2-Kilodalton Macrophage-Activating Lipopeptide of Mycoplasma fermentans after Pulmonary Application by LÜHRMANN, Anke, DEITERS, Ursula, SKOKOWA, Julia, HANKE, Michaela, GESSNER, Johannes E, MÜHLRADT, Peter F, PABST, Reinhard, TSCHERNIG, Thomas

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Epothilone B stabilizes microtubuli of macrophages like Taxol without showing Taxol-like endotoxin activity by MÜHLRADT, P. F, SASSE, F

“…Epothilones are a new class of potential antitumor compounds that were isolated from the myxobacterium Sorangium cellulosum. Epothilones have effects on the…”
Get full text

Synthetic mycoplasma-derived lipopeptide MALP-2 induces maturation and function of dendritic cells by Weigt, Henning, Mühlradt, Peter F., Emmendörffer, Andreas, Krug, Norbert, Braun, Armin

“…Dendritic cells (DC) modulate immune responses depending on the nature of the antigens. Receptors capable of discriminating these antigens on the basis of the…”
Get full text

Purification and partial biochemical characterization of a Mycoplasma fermentans-derived substance that activates macrophages to release nitric oxide, tumor necrosis factor, and interleukin-6 by Muehlradt, P F, Frisch, M

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Identification of S-(2,3-Dihydroxypropyl)cystein in a Macrophage-Activating Lipopeptide from Mycoplasma fermentans by Mühlradt, Peter F, Meyer, Holger, Jansen, Rolf

“…Mycoplasmas are capable of stimulating monocytes and macrophages to release cytokines, prostaglandins, and nitric oxide. The aim of this study was to…”
Get full text

Activation of nuclear factor‐κB in macrophages by mycoplasmal lipopeptides by Sacht, Gudrun, Märten, Angela, Deiters, Ursula, Süßmuth, Roderich, Jung, Günther, Wingender, Edgar, Mühlradt, Peter F.

“…Mycoplasmas are potent macrophage stimulators. The active principle are lipopeptides or lipoproteins with a characteristic N‐terminal…”
Get full text

MDHM, a macrophage-stimulatory product of Mycoplasma fermentans, leads to in vitro interleukin-1 (IL-1), IL-6, tumor necrosis factor, and prostaglandin production and is pyrogenic in rabbits by Muehlradt, P F, Schade, U

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Mycoplasma fermentans-derived lipid inhibits class II major histocompatibility complex expression without mediation by interleukin-6, interleukin-10, tumor necrosis factor, transforming growth factor-beta, type I interferon, prostaglandins or nitric oxide by Frisch, M, Gradehandt, G, Mühlradt, P F

“…Mycoplasma cause several diseases in man and animals. Some strains can chronically infect humans, leading to fever or inflammatory syndromes such as arthritis,…”
Get more information

Role of IL-6, IL-2, and IL-4 in the in vitro induction of cytotoxic T cells by Quentmeier, H, Klaucke, J, Muhlradt, PF, Drexler, HG

“…The mode of IL-6-induced differentiation of Con A-stimulated CD4-CD8+ CTL-P was examined. Through application of neutralizing anti-IL-6, anti-IL-2, and…”
Get full text