Search Results - "Muehlbacher, Markus"

Identification of Drugs Inducing Phospholipidosis by Novel in vitro Data by Muehlbacher, Markus, Tripal, Philipp, Roas, Florian, Kornhuber, Johannes

“…Drug‐induced phospholipidosis (PLD) is a lysosomal storage disorder characterized by the accumulation of phospholipids within the lysosome. This adverse drug…”
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Identification of novel functional inhibitors of acid sphingomyelinase by Kornhuber, Johannes, Muehlbacher, Markus, Trapp, Stefan, Pechmann, Stefanie, Friedl, Astrid, Reichel, Martin, Mühle, Christiane, Terfloth, Lothar, Groemer, Teja W, Spitzer, Gudrun M, Liedl, Klaus R, Gulbins, Erich, Tripal, Philipp

“…We describe a hitherto unknown feature for 27 small drug-like molecules, namely functional inhibition of acid sphingomyelinase (ASM). These entities named…”
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Identification of PPARgamma partial agonists of natural origin (I): development of a virtual screening procedure and in vitro validation by Guasch, Laura, Sala, Esther, Castell-Auví, Anna, Cedó, Lidia, Liedl, Klaus R, Wolber, Gerhard, Muehlbacher, Markus, Mulero, Miquel, Pinent, Montserrat, Ardévol, Anna, Valls, Cristina, Pujadas, Gerard, Garcia-Vallvé, Santiago

“…Although there are successful examples of the discovery of new PPARγ agonists, it has recently been of great interest to identify new PPARγ partial agonists…”
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Qualitative prediction of blood–brain barrier permeability on a large and refined dataset by Muehlbacher, Markus, Spitzer, Gudrun M., Liedl, Klaus R., Kornhuber, Johannes

“…The prediction of blood–brain barrier permeation is vitally important for the optimization of drugs targeting the central nervous system as well as for…”
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Functional Inhibitors of Acid Sphingomyelinase (FIASMAs): A Novel Pharmacological Group of Drugs with Broad Clinical Applications by Kornhuber, Johannes, Tripal, Philipp, Reichel, Martin, Mühle, Christiane, Rhein, Cosima, Muehlbacher, Markus, Groemer, Teja W., Gulbins, Erich

“…Acid sphingomyelinase (ASM) is an important lipid-metabolizing enzyme cleaving sphingomyelin to ceramide, mainly within lysosomes. Acid ceramidase (AC) further…”
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Drug-induced phospholipidosis caused by combinations of common drugs in vitro by Glock, Mareike, Muehlbacher, Markus, Hurtig, Henoch, Tripal, Philipp, Kornhuber, Johannes

“…Drug-induced phospholipidosis (DIPLD), characterized by the accumulation of phospholipids within lysosomes, is suspected to impair lysosomal function and…”
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Functional inhibitors of acid sphingomyelinase (FIASMAs) by Kornhuber, Johannes, Tripal, Philipp, Gulbins, Erich, Muehlbacher, Markus

“…Sphingolipids are not only structural components of biological membranes, but also play an important role in cellular signalling and, thus, are involved in…”
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Conformation-Dependent QSPR Models: logPOW by Muehlbacher, Markus, Kerdawy, Ahmed El, Kramer, Christian, Hudson, Brian, Clark, Timothy

“…Quantitative structure–property relationships for predicting the water–octanol partition coefficient, logPOW, are reported. The models are based on local…”
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Cover Picture: Identification of Drugs Inducing Phospholipidosis by Novel in vitro Data (ChemMedChem 11/2012) by Muehlbacher, Markus, Tripal, Philipp, Roas, Florian, Kornhuber, Johannes

“…Drug-induced phospholipidosis (PLD) is a lysosomal storage disorder characterized by the accumulation of phospholipids within the lysosome. This adverse drug…”
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Conformation-Dependent QSPR Models: logP OW by Muehlbacher, Markus, Kerdawy, Ahmed El, Kramer, Christian, Hudson, Brian, Clark, Timothy

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Conformation-Dependent QSPR Models: logP^sub OW by Muehlbacher, Markus, El Kerdawy, Ahmed, Kramer, Christian, Hudson, Brian, Clark, Timothy

“…Quantitative structure-property relationships for predicting the water-octanol partition coefficient, logPOW, are reported. The models are based on local…”
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Identification of PPARgamma Partial Agonists of Natural Origin by Guasch, Laura, Sala, Esther, Castell-Auví, Anna, Cedó, Lidia, Liedl, Klaus R, Wolber, Gerhard, Muehlbacher, Markus, Mulero, Miquel, Pinent, Montserrat, Ardévol, Anna, Valls, Cristina, Pujadas, Gerard, Garcia-Vallvé, Santiago

“…Background Although there are successful examples of the discovery of new PPAR[gamma] agonists, it has recently been of great interest to identify new…”
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