Search Results - "Muecksch, Frauke"

Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies by Greaney, Allison J., Starr, Tyler N., Barnes, Christopher O., Weisblum, Yiska, Schmidt, Fabian, Caskey, Marina, Gaebler, Christian, Cho, Alice, Agudelo, Marianna, Finkin, Shlomo, Wang, Zijun, Poston, Daniel, Muecksch, Frauke, Hatziioannou, Theodora, Bieniasz, Paul D., Robbiani, Davide F., Nussenzweig, Michel C., Bjorkman, Pamela J., Bloom, Jesse D.

“…Monoclonal antibodies targeting a variety of epitopes have been isolated from individuals previously infected with SARS-CoV-2, but the relative contributions…”
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Vaccine Breakthrough Infections with SARS-CoV-2 Variants by Hacisuleyman, Ezgi, Hale, Caryn, Saito, Yuhki, Blachere, Nathalie E, Bergh, Marissa, Conlon, Erin G, Schaefer-Babajew, Dennis J, DaSilva, Justin, Muecksch, Frauke, Gaebler, Christian, Lifton, Richard, Nussenzweig, Michel C, Hatziioannou, Theodora, Bieniasz, Paul D, Darnell, Robert B

“…Mild Covid-19 symptoms developed in two fully vaccinated persons. Serum tests showed high titers of antibodies capable of neutralizing the wild-type strain of…”
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Plasma Neutralization of the SARS-CoV-2 Omicron Variant by Schmidt, Fabian, Muecksch, Frauke, Weisblum, Yiska, Da Silva, Justin, Bednarski, Eva, Cho, Alice, Wang, Zijun, Gaebler, Christian, Caskey, Marina, Nussenzweig, Michel C, Hatziioannou, Theodora, Bieniasz, Paul D

“…Neutralization assays of SARS-CoV-2 pseudoviruses expressing wild-type, omicron, or a synthetic resistant spike protein in plasma drawn from 47 people over…”
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mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants by Wang, Zijun, Schmidt, Fabian, Weisblum, Yiska, Muecksch, Frauke, Barnes, Christopher O., Finkin, Shlomo, Schaefer-Babajew, Dennis, Cipolla, Melissa, Gaebler, Christian, Lieberman, Jenna A., Oliveira, Thiago Y., Yang, Zhi, Abernathy, Morgan E., Huey-Tubman, Kathryn E., Hurley, Arlene, Turroja, Martina, West, Kamille A., Gordon, Kristie, Millard, Katrina G., Ramos, Victor, Da Silva, Justin, Xu, Jianliang, Colbert, Robert A., Patel, Roshni, Dizon, Juan, Unson-O’Brien, Cecille, Shimeliovich, Irina, Gazumyan, Anna, Caskey, Marina, Bjorkman, Pamela J., Casellas, Rafael, Hatziioannou, Theodora, Bieniasz, Paul D., Nussenzweig, Michel C.

“…Here we report on the antibody and memory B cell responses of a cohort of 20 volunteers who received the Moderna (mRNA-1273) or Pfizer–BioNTech (BNT162b2)…”
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Measuring SARS-CoV-2 neutralizing antibody activity using pseudotyped and chimeric viruses by Schmidt, Fabian, Weisblum, Yiska, Muecksch, Frauke, Hoffmann, Hans-Heinrich, Michailidis, Eleftherios, Lorenzi, Julio C C, Mendoza, Pilar, Rutkowska, Magdalena, Bednarski, Eva, Gaebler, Christian, Agudelo, Marianna, Cho, Alice, Wang, Zijun, Gazumyan, Anna, Cipolla, Melissa, Caskey, Marina, Robbiani, Davide F, Nussenzweig, Michel C, Rice, Charles M, Hatziioannou, Theodora, Bieniasz, Paul D

“…The emergence of SARS-CoV-2 and the ensuing explosive epidemic of COVID-19 disease has generated a need for assays to rapidly and conveniently measure the…”
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Longitudinal Serological Analysis and Neutralizing Antibody Levels in Coronavirus Disease 2019 Convalescent Patients by Muecksch, Frauke, Wise, Helen, Batchelor, Becky, Squires, Maria, Semple, Elizabeth, Richardson, Claire, McGuire, Jacqueline, Clearly, Sarah, Furrie, Elizabeth, Greig, Neil, Hay, Gordon, Templeton, Kate, Lorenzi, Julio C C, Hatziioannou, Theodora, Jenks, Sara, Bieniasz, Paul D

“…Abstract Background Understanding the longitudinal trajectory of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies is crucial for…”
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Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection by Wang, Zijun, Muecksch, Frauke, Schaefer-Babajew, Dennis, Finkin, Shlomo, Viant, Charlotte, Gaebler, Christian, Hoffmann, Hans- Heinrich, Barnes, Christopher O., Cipolla, Melissa, Ramos, Victor, Oliveira, Thiago Y., Cho, Alice, Schmidt, Fabian, Da Silva, Justin, Bednarski, Eva, Aguado, Lauren, Yee, Jim, Daga, Mridushi, Turroja, Martina, Millard, Katrina G., Jankovic, Mila, Gazumyan, Anna, Zhao, Zhen, Rice, Charles M., Bieniasz, Paul D., Caskey, Marina, Hatziioannou, Theodora, Nussenzweig, Michel C.

“…More than one year after its inception, the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)…”
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Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies by Barnes, Christopher O., West, Anthony P., Huey-Tubman, Kathryn E., Hoffmann, Magnus A.G., Sharaf, Naima G., Hoffman, Pauline R., Koranda, Nicholas, Gristick, Harry B., Gaebler, Christian, Muecksch, Frauke, Lorenzi, Julio C. Cetrulo, Finkin, Shlomo, Hägglöf, Thomas, Hurley, Arlene, Millard, Katrina G., Weisblum, Yiska, Schmidt, Fabian, Hatziioannou, Theodora, Bieniasz, Paul D., Caskey, Marina, Robbiani, Davide F., Nussenzweig, Michel C., Bjorkman, Pamela J.

“…Neutralizing antibody responses to coronaviruses mainly target the receptor-binding domain (RBD) of the trimeric spike. Here, we characterized polyclonal…”
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Enhanced SARS-CoV-2 neutralization by dimeric IgA by Wang, Zijun, Lorenzi, Julio C C, Muecksch, Frauke, Finkin, Shlomo, Viant, Charlotte, Gaebler, Christian, Cipolla, Melissa, Hoffmann, Hans-Heinrich, Oliveira, Thiago Y, Oren, Deena A, Ramos, Victor, Nogueira, Lilian, Michailidis, Eleftherios, Robbiani, Davide F, Gazumyan, Anna, Rice, Charles M, Hatziioannou, Theodora, Bieniasz, Paul D, Caskey, Marina, Nussenzweig, Michel C

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19), primarily infects cells at mucosal…”
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Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants by Weisblum, Yiska, Schmidt, Fabian, Zhang, Fengwen, DaSilva, Justin, Poston, Daniel, Lorenzi, Julio Cc, Muecksch, Frauke, Rutkowska, Magdalena, Hoffmann, Hans-Heinrich, Michailidis, Eleftherios, Gaebler, Christian, Agudelo, Marianna, Cho, Alice, Wang, Zijun, Gazumyan, Anna, Cipolla, Melissa, Luchsinger, Larry, Hillyer, Christopher D, Caskey, Marina, Robbiani, Davide F, Rice, Charles M, Nussenzweig, Michel C, Hatziioannou, Theodora, Bieniasz, Paul D

“…Neutralizing antibodies elicited by prior infection or vaccination are likely to be key for future protection of individuals and populations against…”
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Increased memory B cell potency and breadth after a SARS-CoV-2 mRNA boost by Muecksch, Frauke, Wang, Zijun, Cho, Alice, Gaebler, Christian, Ben Tanfous, Tarek, DaSilva, Justin, Bednarski, Eva, Ramos, Victor, Zong, Shuai, Johnson, Brianna, Raspe, Raphael, Schaefer-Babajew, Dennis, Shimeliovich, Irina, Daga, Mridushi, Yao, Kai-Hui, Schmidt, Fabian, Millard, Katrina G., Turroja, Martina, Jankovic, Mila, Oliveira, Thiago Y., Gazumyan, Anna, Caskey, Marina, Hatziioannou, Theodora, Bieniasz, Paul D., Nussenzweig, Michel C.

“…The Omicron variant of SARS-CoV-2 infected many vaccinated and convalescent individuals 1 – 3 . Despite the reduced protection from infection, individuals who…”
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Anti-SARS-CoV-2 receptor-binding domain antibody evolution after mRNA vaccination by Cho, Alice, Muecksch, Frauke, Schaefer-Babajew, Dennis, Wang, Zijun, Finkin, Shlomo, Gaebler, Christian, Ramos, Victor, Cipolla, Melissa, Mendoza, Pilar, Agudelo, Marianna, Bednarski, Eva, DaSilva, Justin, Shimeliovich, Irina, Dizon, Juan, Daga, Mridushi, Millard, Katrina G., Turroja, Martina, Schmidt, Fabian, Zhang, Fengwen, Tanfous, Tarek Ben, Jankovic, Mila, Oliveria, Thiago Y., Gazumyan, Anna, Caskey, Marina, Bieniasz, Paul D., Hatziioannou, Theodora, Nussenzweig, Michel C.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection produces B cell responses that continue to evolve for at least a year. During that time,…”
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Antibody potency, effector function, and combinations in protection and therapy for SARS-CoV-2 infection in vivo by Schäfer, Alexandra, Muecksch, Frauke, Lorenzi, Julio C C, Leist, Sarah R, Cipolla, Melissa, Bournazos, Stylianos, Schmidt, Fabian, Maison, Rachel M, Gazumyan, Anna, Martinez, David R, Baric, Ralph S, Robbiani, Davide F, Hatziioannou, Theodora, Ravetch, Jeffrey V, Bieniasz, Paul D, Bowen, Richard A, Nussenzweig, Michel C, Sheahan, Timothy P

“…SARS-CoV-2, the causative agent of COVID-19, has been responsible for over 42 million infections and 1 million deaths since its emergence in December 2019…”
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Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations by Muecksch, Frauke, Weisblum, Yiska, Barnes, Christopher O., Schmidt, Fabian, Schaefer-Babajew, Dennis, Wang, Zijun, C. Lorenzi, Julio C., Flyak, Andrew I., DeLaitsch, Andrew T., Huey-Tubman, Kathryn E., Hou, Shurong, Schiffer, Celia A., Gaebler, Christian, Da Silva, Justin, Poston, Daniel, Finkin, Shlomo, Cho, Alice, Cipolla, Melissa, Oliveira, Thiago Y., Millard, Katrina G., Ramos, Victor, Gazumyan, Anna, Rutkowska, Magdalena, Caskey, Marina, Nussenzweig, Michel C., Bjorkman, Pamela J., Hatziioannou, Theodora, Bieniasz, Paul D.

“…Antibodies elicited by infection accumulate somatic mutations in germinal centers that can increase affinity for cognate antigens. We analyzed 6 independent…”
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Nanobodies from camelid mice and llamas neutralize SARS-CoV-2 variants by Xu, Jianliang, Xu, Kai, Jung, Seolkyoung, Conte, Andrea, Lieberman, Jenna, Muecksch, Frauke, Lorenzi, Julio Cesar Cetrulo, Park, Solji, Schmidt, Fabian, Wang, Zijun, Huang, Yaoxing, Luo, Yang, Nair, Manoj S., Wang, Pengfei, Schulz, Jonathan E., Tessarollo, Lino, Bylund, Tatsiana, Chuang, Gwo-Yu, Olia, Adam S., Stephens, Tyler, Teng, I-Ting, Tsybovsky, Yaroslav, Zhou, Tongqing, Munster, Vincent, Ho, David D., Hatziioannou, Theodora, Bieniasz, Paul D., Nussenzweig, Michel C., Kwong, Peter D., Casellas, Rafael

“…Since the start of the COVID-19 pandemic, SARS-CoV-2 has caused millions of deaths worldwide. Although a number of vaccines have been deployed, the continual…”
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Antibody feedback regulates immune memory after SARS-CoV-2 mRNA vaccination by Schaefer-Babajew, Dennis, Wang, Zijun, Muecksch, Frauke, Cho, Alice, Loewe, Maximilian, Cipolla, Melissa, Raspe, Raphael, Johnson, Brianna, Canis, Marie, DaSilva, Justin, Ramos, Victor, Turroja, Martina, Millard, Katrina G., Schmidt, Fabian, Witte, Leander, Dizon, Juan, Shimeliovich, Irina, Yao, Kai-Hui, Oliveira, Thiago Y., Gazumyan, Anna, Gaebler, Christian, Bieniasz, Paul D., Hatziioannou, Theodora, Caskey, Marina, Nussenzweig, Michel C.

“…Feedback inhibition of humoral immunity by antibodies was first documented in 1909 1 . Subsequent studies showed that, depending on the context, antibodies can…”
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B cell genomics behind cross-neutralization of SARS-CoV-2 variants and SARS-CoV by Scheid, Johannes F., Barnes, Christopher O., Eraslan, Basak, Hudak, Andrew, Keeffe, Jennifer R., Cosimi, Lisa A., Brown, Eric M., Muecksch, Frauke, Weisblum, Yiska, Zhang, Shuting, Delorey, Toni, Woolley, Ann E., Ghantous, Fadi, Park, Sung-Moo, Phillips, Devan, Tusi, Betsabeh, Huey-Tubman, Kathryn E., Cohen, Alexander A., Gnanapragasam, Priyanthi N.P., Rzasa, Kara, Hatziioanno, Theodora, Durney, Michael A., Gu, Xiebin, Tada, Takuya, Landau, Nathaniel R., West, Anthony P., Rozenblatt-Rosen, Orit, Seaman, Michael S., Baden, Lindsey R., Graham, Daniel B., Deguine, Jacques, Bieniasz, Paul D., Regev, Aviv, Hung, Deborah, Bjorkman, Pamela J., Xavier, Ramnik J.

“…Monoclonal antibodies (mAbs) are a focus in vaccine and therapeutic design to counteract severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its…”
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Epistasis lowers the genetic barrier to SARS-CoV-2 neutralizing antibody escape by Witte, Leander, Baharani, Viren A., Schmidt, Fabian, Wang, Zijun, Cho, Alice, Raspe, Raphael, Guzman-Cardozo, Camila, Muecksch, Frauke, Canis, Marie, Park, Debby J., Gaebler, Christian, Caskey, Marina, Nussenzweig, Michel C., Hatziioannou, Theodora, Bieniasz, Paul D.

“…Waves of SARS-CoV-2 infection have resulted from the emergence of viral variants with neutralizing antibody resistance mutations. Simultaneously, repeated…”
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Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodies by Jette, Claudia A., Cohen, Alexander A., Gnanapragasam, Priyanthi N.P., Muecksch, Frauke, Lee, Yu E., Huey-Tubman, Kathryn E., Schmidt, Fabian, Hatziioannou, Theodora, Bieniasz, Paul D., Nussenzweig, Michel C., West, Anthony P., Keeffe, Jennifer R., Bjorkman, Pamela J., Barnes, Christopher O.

“…Many anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) neutralizing antibodies target the angiotensin-converting enzyme 2 (ACE2) binding…”
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Memory B cell responses to Omicron subvariants after SARS-CoV-2 mRNA breakthrough infection in humans by Wang, Zijun, Zhou, Pengcheng, Muecksch, Frauke, Cho, Alice, Ben Tanfous, Tarek, Canis, Marie, Witte, Leander, Johnson, Brianna, Raspe, Raphael, Schmidt, Fabian, Bednarski, Eva, Da Silva, Justin, Ramos, Victor, Zong, Shuai, Turroja, Martina, Millard, Katrina G, Yao, Kai-Hui, Shimeliovich, Irina, Dizon, Juan, Kaczynska, Anna, Jankovic, Mila, Gazumyan, Anna, Oliveira, Thiago Y, Caskey, Marina, Gaebler, Christian, Bieniasz, Paul D, Hatziioannou, Theodora, Nussenzweig, Michel C

“…Individuals who receive a third mRNA vaccine dose show enhanced protection against severe COVID-19, but little is known about the impact of breakthrough…”
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