Search Results - "Mudzunga, Theophilus T."

Synthesis of 2-Deoxy-2-C-Alkylglucosides of myo-Inositol as possible inhibitors of a N-Deacetylase enzyme in the biosynthesis of mycothiol by Gammon, David W., Hunter, Roger, Steenkamp, Daniel J., Mudzunga, Theophilus T.

“…Two new analogues of 1- d-1- O-(2-acetamido-2-deoxy-α- d-glucopyranosyl)- myo-inositol, a biosynthetic intermediate in the production of mycothiol in the…”
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Conjugates of plumbagin and phenyl-2-amino-1-thioglucoside inhibit MshB, a deacetylase involved in the biosynthesis of mycothiol by Gammon, David W., Steenkamp, Daniel J., Mavumengwana, Vuyo, Marakalala, Mohlopheni J., Mudzunga, Theophilus T., Hunter, Roger, Munyololo, Muganza

“…Compounds 1a–d with plumbagin tethered to a phenyl-2-amino-thioglucoside are potent inhibitors of the amidase mshB in the Mycobacteria…”
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