Search Results - "Mudrak, Ingrid"
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Protein Phosphatase Methyl-Esterase PME-1 Protects Protein Phosphatase 2A from Ubiquitin/Proteasome Degradation
Published in PloS one (17-12-2015)“…Protein phosphatase 2A (PP2A) is a conserved essential enzyme that is implicated as a tumor suppressor based on its central role in phosphorylation-dependent…”
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2
Budding yeast greatwall and endosulfines control activity and spatial regulation of PP2A(Cdc55) for timely mitotic progression
Published in PLoS genetics (2013)“…Entry into mitosis is triggered by cyclinB/Cdk1, whose activity is abruptly raised by a positive feedback loop. The Greatwall kinase phosphorylates proteins of…”
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3
Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I
Published in Nature (04-05-2006)“…Segregation of homologous maternal and paternal centromeres to opposite poles during meiosis I depends on post-replicative crossing over between homologous…”
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4
PP2AC Phospho-Tyr307 Antibodies Are Not Specific for this Modification but Are Sensitive to Other PP2AC Modifications Including Leu309 Methylation
Published in Cell reports (Cambridge) (03-03-2020)“…Protein phosphatase 2A (PP2A) is an important regulator of signal transduction pathways and a tumor suppressor. Phosphorylation of the PP2A catalytic subunit…”
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5
Downregulation of Protein Phosphatase 2A Carboxyl Methylation and Methyltransferase May Contribute to Alzheimer Disease Pathogenesis
Published in Journal of neuropathology and experimental neurology (01-10-2004)“…ABαC, a major protein phosphatase 2A (PP2A) heterotrimeric enzyme, binds to and regulates the microtubule cytoskeleton and tau. We have shown that ABαC protein…”
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6
Generation of active protein phosphatase 2A is coupled to holoenzyme assembly
Published in PLoS biology (01-06-2007)“…Protein phosphatase 2A (PP2A) is a prime example of the multisubunit architecture of protein serine/threonine phosphatases. Until substrate-specific PP2A…”
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7
M-Track: detecting short-lived protein-protein interactions in vivo
Published in Nature methods (01-06-2012)“…A proximity assay based on methylation of interacting 'prey' proteins by a 'bait' fused to the histone lysine methyltransferase permits the detection of…”
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8
Budding Yeast Greatwall and Endosulfines Control Activity and Spatial Regulation of PP2ACdc55 for Timely Mitotic Progression
Published in PLoS genetics (04-07-2013)“…Entry into mitosis is triggered by cyclinB/Cdk1, whose activity is abruptly raised by a positive feedback loop. The Greatwall kinase phosphorylates proteins of…”
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9
A novel and essential mechanism determining specificity and activity of protein phosphatase 2A (PP2A) in vivo
Published in Genes & development (01-09-2003)“…Protein phosphatase 2A (PP2A) is an essential intracellular serine/threonine phosphatase containing a catalytic subunit that possesses the potential to…”
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10
Loss of LCMT1 and biased protein phosphatase 2A heterotrimerization drive prostate cancer progression and therapy resistance
Published in Nature communications (29-08-2023)“…Loss of the tumor suppressive activity of the protein phosphatase 2A (PP2A) is associated with cancer, but the underlying molecular mechanisms are unclear…”
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11
Anti-RAINBOW dye-specific antibodies as universal tools for the visualization of prestained protein molecular weight markers in Western blot analysis
Published in Scientific reports (17-08-2016)“…Western blotting is one of the most widely used techniques in molecular biology and biochemistry. Prestained proteins are used as molecular weight standards in…”
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12
Catalytically Inactive Protein Phosphatase 2A Can Bind to Polyomavirus Middle Tumor Antigen and Support Complex Formation with pp60c-src
Published in Journal of Virology (01-09-1999)“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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13
Altered Expression Levels of the Protein Phosphatase 2A ABαC Enzyme Are Associated with Alzheimer Disease Pathology
Published in Journal of neuropathology and experimental neurology (01-04-2004)“…The formation of amyloid-containing senile plaques and tau-rich neurofibrillary tangles are central events in Alzheimer disease (AD) pathogenesis…”
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14
Budding Yeast Greatwall and Endosulfines Control Activity and Spatial Regulation of PP2ACdc55 for Timely Mitotic Progression: e1003575
Published in PLoS genetics (01-07-2013)“…Entry into mitosis is triggered by cyclinB/Cdk1, whose activity is abruptly raised by a positive feedback loop. The Greatwall kinase phosphorylates proteins of…”
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15
Budding yeast Greatwall and endosulfines control activity and spatial regulation of [PP2A.sup.Cdc55] for timely mitotic progression
Published in PLoS genetics (01-07-2013)“…Entry into mitosis is triggered by cyclinB/Cdk1, whose activity is abruptly raised by a positive feedback loop. The Greatwall kinase phosphorylates proteins of…”
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16
PP2A C Phospho-Tyr 307 Antibodies Are Not Specific for this Modification but Are Sensitive to Other PP2A C Modifications Including Leu 309 Methylation
Published in Cell reports (Cambridge) (03-03-2020)“…Protein phosphatase 2A (PP2A) is an important regulator of signal transduction pathways and a tumor suppressor. Phosphorylation of the PP2A catalytic subunit…”
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Journal Article -
17
Expression of protein phosphatase 2A mutants and silencing of the regulatory Bα subunit induce a selective loss of acetylated and detyrosinated microtubules
Published in Journal of neurochemistry (01-05-2007)“…Carboxymethylation and phosphorylation of protein phosphatase 2A (PP2A) catalytic C subunit are evolutionary conserved mechanisms that critically control PP2A…”
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18
Identification of a Subunit of a Novel Kleisin-β/SMC Complex as a Potential Substrate of Protein Phosphatase 2A
Published in Current biology (02-12-2003)“…Protein phosphatase 2A (PP2A) holoenzymes consist of a catalytic C subunit, a scaffolding A subunit, and one of several regulatory B subunits that recruit the…”
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19
Expression of protein phosphatase 2A mutants and silencing of the regulatory B[alpha] subunit induce a selective loss of acetylated and detyrosinated microtubules
Published in Journal of neurochemistry (01-05-2007)“…Carboxymethylation and phosphorylation of protein phosphatase 2A (PP2A) catalytic C subunit are evolutionary conserved mechanisms that critically control PP2A…”
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20
Catalytically inactive protein phosphatase 2A can bind to polyomavirus middle tumor antigen and support complex formation with pp60(c-src)
Published in Journal of virology (01-09-1999)“…Interaction between the heterodimeric form of protein phosphatase 2A (PP2A) and polyomavirus middle T antigen (MT) is required for the subsequent assembly of a…”
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