Search Results - "Muddle, John R."

Ndrg1 in development and maintenance of the myelin sheath by King, Rosalind H.M, Chandler, David, Lopaticki, Sash, Huang, Dexing, Blake, Julian, Muddle, John R, Kilpatrick, Trevor, Nourallah, Michelle, Miyata, Toshiyuki, Okuda, Tomohiko, Carter, Kim W, Hunter, Michael, Angelicheva, Dora, Morahan, Grant, Kalaydjieva, Luba

“…Abstract CMT4D disease is a severe autosomal recessive demyelinating neuropathy with extensive axonal loss leading to early disability, caused by mutations in…”
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Proteasomal inhibition causes loss of nigral tyrosine hydroxylase neurons by Schapira, Anthony H. V., Cleeter, Michael W. J., Muddle, John R., Workman, Jane M., Cooper, J. Mark, King, Rosalind H. M.

“…Dysfunction of the ubiquitin‐proteasomal system (UPS) has been implicated in the pathogenesis of Parkinson's disease. The systemic administration of UPS…”
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The “no-touch” harvesting technique for vein grafts in coronary artery bypass surgery preserves an intact vasa vasorum by Dreifaldt, Mats, Souza, Domingos S.R, Loesch, Andrzej, Muddle, John R, Karlsson, Mats G, Filbey, Derek, Bodin, Lennart, Norgren, Lars, Dashwood, Michael R

“…Objectives Our objective was to evaluate the impact of vein graft harvesting technique on structure and function of vasa vasorum. Methods Paired segments of…”
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Myelin and Axon Pathology in a Long-Term Study of PMP22-Overexpressing Mice by Verhamme, Camiel, King, Rosalind H.M, ten Asbroek, Anneloor L.M.A, Muddle, John R, Nourallah, Michelle, Wolterman, Ruud, Baas, Frank, van Schaik, Ivo N

“…We analyzed clinical and pathological disease in 2 peripheral myelin protein-22 (PMP22) overexpressing mouse models for 1.5years. C22 mice have 7 and C3-PMP…”
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A novel RAB7 mutation associated with ulcero-mutilating neuropathy by Houlden, Henry, King, Rosalind H. M., Muddle, John R., Warner, Thomas T., Reilly, Mary M., Orrell, Richard W., Ginsberg, Lionel

“…There are two known autosomal dominant genes for the hereditary ulcero‐mutilating neuropathies: SPTLC1 (hereditary sensory neuropathy type 1) and RAB7…”
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Coexistent hereditary and inflammatory neuropathy by Ginsberg, Lionel, Malik, Omar, Kenton, Anthony R., Sharp, David, Muddle, John R., Davis, Mary B., Winer, John B., Orrell, Richard W., King, Rosalind H. M.

“…Classically, the course of Charcot–Marie–Tooth (CMT) disease is gradually progressive. We describe eight atypical patients who developed acute or subacute…”
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Mitochondrial DNA depletion can be prevented by dGMP and dAMP supplementation in a resting culture of deoxyguanosine kinase-deficient fibroblasts by Taanman, Jan-Willem, Muddle, John R., Muntau, Ania C.

“…Deoxyguanosine kinase is a constitutively expressed, mitochondrial enzyme of the deoxyribonucleoside salvage pathway. Deficiency of deoxyguanosine kinase…”
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Characterization of a novel TYMP splice site mutation associated with mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) by Taanman, Jan-Willem, Daras, Mariza, Albrecht, Juliane, Davie, Charles A, Mallam, Elizabeth A, Muddle, John R, Weatherall, Mark, Warner, Thomas T, Schapira, Anthony H.V, Ginsberg, Lionel

“…Abstract Mitochondrial neurogastrointestinal encephalomyopathy is an autosomal recessive disorder caused by loss-of-function mutations in the thymidine…”
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Hereditary motor and sensory neuropathy-russe: New autosomal recessive neuropathy in balkan gypsies by Thomas, P. K., Kalaydjieva, Luba, Youl, Brian, Rogers, Tamara, Angelicheva, Dora, King, Rosalind H. M., Guergueltcheva, Velina, Colomer, Jaume, Lupu, Constantin, Corches, Axinia, Popa, Gabriela, Merlini, Luciano, Shmarov, Alex, Muddle, John R., Nourallah, Michelle, Tournev, Ivailo

“…A novel peripheral neuropathy of autosomal recessive inheritance has been identified in Balkan Gypsies and termed hereditary motor and sensory neuropathy‐Russe…”
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The effect of the ETA receptor antagonist, FR 139317, on [125I]‐ET‐1 binding to the atherosclerotic human coronary artery by Dashwood, Michael R., Allen, Sean P., Luu, Thin N., Muddle, John R.

“…1 The distribution of [125I]‐endothelin (ET‐1) binding sites on atherosclerotic human epicardial coronary arteries has been studied by in vitro receptor…”
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The effect of the ET A receptor antagonist, FR 139317, on [ 125 I]‐ET‐1 binding to the atherosclerotic human coronary artery by Dashwood, Michael R., Allen, Sean P., Luu, Thin N., Muddle, John R.

“…The distribution of [ 125 I]‐endothelin (ET‐1) binding sites on atherosclerotic human epicardial coronary arteries has been studied by in vitro receptor…”
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Binding of [3H]-5-hydroxytryptamine to human coronary artery and bypass graft vessels by DAHM, P. L, BODELSSON, M, TÖRNEBRANDT, K, MUDDLE, J. R, SYKES, R. M, YACOUB, M, DASHWOOD, M. R

“…5-Hydroxytryptamine (5-HT) has a wide range of vascular effects mediated via specific receptors and it has been suggested to be a mediator in ischemic heart…”
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Binding of [3H]-5-hydroxytryptamine to human coronary artery and bypass graft vessels by Dahm, Peter L., Bodelsson, Mikael, Törnebrandt, Kenneth, Muddle, John R., Sykes, Rachel M., Yacoub, Magdi, Dashwood, Michael R.

“…AbstractObjectives 5-Hydroxytryptamine (5-HT) has a wide range of vascular effects mediated via specific receptors and it has been suggested to be a mediator…”
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Regional variations in endothelin-1 and its receptor subtypes in human coronary vasculature: pathophysiological implications in coronary disease by Dashwood, M R, Timm, M, Muddle, J R, Ong, A C, Tippins, J R, Parker, R, McManus, D, Murday, A J, Madden, B P, Kaski, J C

“…Endothelin-1 is a potent vasoconstrictor peptide and mitogen for vascular smooth muscle cells. Increased plasma or tissue levels of endothelin-1 have been…”
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Opiate receptor subtypes in the nucleus tractus solitarii of the cat: the effect of vagal section by Dashwood, M R, Muddle, J R, Spyer, K M

“…The distribution of mu, delta and kappa opioid receptors in the lower brainstem of the cat has been determined autoradiographically by studying the binding of…”
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