Search Results - "Mudd, Michal"

TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis by Chauhan, Santosh, Kumar, Suresh, Jain, Ashish, Ponpuak, Marisa, Mudd, Michal H., Kimura, Tomonori, Choi, Seong Won, Peters, Ryan, Mandell, Michael, Bruun, Jack-Ansgar, Johansen, Terje, Deretic, Vojo

“…Selective autophagy performs an array of tasks to maintain intracellular homeostasis, sterility, and organellar and cellular functionality. The fidelity of…”
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Galectins Control mTOR in Response to Endomembrane Damage by Jia, Jingyue, Abudu, Yakubu Princely, Claude-Taupin, Aurore, Gu, Yuexi, Kumar, Suresh, Choi, Seong Won, Peters, Ryan, Mudd, Michal H., Allers, Lee, Salemi, Michelle, Phinney, Brett, Johansen, Terje, Deretic, Vojo

“…The Ser/Thr protein kinase mTOR controls metabolic pathways, including the catabolic process of autophagy. Autophagy plays additional, catabolism-independent…”
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Galectin-3 Coordinates a Cellular System for Lysosomal Repair and Removal by Jia, Jingyue, Claude-Taupin, Aurore, Gu, Yuexi, Choi, Seong Won, Peters, Ryan, Bissa, Bhawana, Mudd, Michal H., Allers, Lee, Pallikkuth, Sandeep, Lidke, Keith A., Salemi, Michelle, Phinney, Brett, Mari, Muriel, Reggiori, Fulvio, Deretic, Vojo

“…Endomembrane damage elicits homeostatic responses including ESCRT-dependent membrane repair and autophagic removal of damaged organelles. Previous studies have…”
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Phosphorylation of Syntaxin 17 by TBK1 Controls Autophagy Initiation by Kumar, Suresh, Gu, Yuexi, Abudu, Yakubu Princely, Bruun, Jack-Ansgar, Jain, Ashish, Farzam, Farzin, Mudd, Michal, Anonsen, Jan Haug, Rusten, Tor Erik, Kasof, Gary, Ktistakis, Nicholas, Lidke, Keith A., Johansen, Terje, Deretic, Vojo

“…Syntaxin 17 (Stx17) has been implicated in autophagosome-lysosome fusion. Here, we report that Stx17 functions in assembly of protein complexes during…”
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Pharmaceutical screen identifies novel target processes for activation of autophagy with a broad translational potential by Chauhan, Santosh, Ahmed, Zahra, Bradfute, Steven B., Arko-Mensah, John, Mandell, Michael A., Won Choi, Seong, Kimura, Tomonori, Blanchet, Fabien, Waller, Anna, Mudd, Michal H., Jiang, Shanya, Sklar, Larry, Timmins, Graham S., Maphis, Nicole, Bhaskar, Kiran, Piguet, Vincent, Deretic, Vojo

“…Autophagy is a conserved homeostatic process active in all human cells and affecting a spectrum of diseases. Here we use a pharmaceutical screen to discover…”
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Mechanism of Stx17 recruitment to autophagosomes via IRGM and mammalian Atg8 proteins by Kumar, Suresh, Jain, Ashish, Farzam, Farzin, Jia, Jingyue, Gu, Yuexi, Choi, Seong Won, Mudd, Michal H, Claude-Taupin, Aurore, Wester, Michael J, Lidke, Keith A, Rusten, Tor-Erik, Deretic, Vojo

“…Autophagy is a conserved eukaryotic process with metabolic, immune, and general homeostatic functions in mammalian cells. Mammalian autophagosomes fuse with…”
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Galectins control MTOR and AMPK in response to lysosomal damage to induce autophagy by Jia, Jingyue, Abudu, Yakubu Princely, Claude-Taupin, Aurore, Gu, Yuexi, Kumar, Suresh, Choi, Seong Won, Peters, Ryan, Mudd, Michal H., Allers, Lee, Salemi, Michelle, Phinney, Brett, Johansen, Terje, Deretic, Vojo

“…The Ser/Thr protein kinase MTOR (mechanistic target of rapamycin kinase) regulates cellular metabolism and controls macroautophagy/autophagy. Autophagy has…”
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Mammalian Atg8 proteins and the autophagy factor IRGM control mTOR and TFEB at a regulatory node critical for responses to pathogens by Kumar, Suresh, Jain, Ashish, Choi, Seong Won, da Silva, Gustavo Peixoto Duarte, Allers, Lee, Mudd, Michal H., Peters, Ryan Scott, Anonsen, Jan Haug, Rusten, Tor-Erik, Lazarou, Michael, Deretic, Vojo

“…Autophagy is a homeostatic process with multiple functions in mammalian cells. Here, we show that mammalian Atg8 proteins (mAtg8s) and the autophagy regulator…”
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Stress granules and mTOR are regulated by membrane atg8ylation during lysosomal damage by Jia, Jingyue, Wang, Fulong, Bhujabal, Zambarlal, Peters, Ryan, Mudd, Michal, Duque, Thabata, Allers, Lee, Javed, Ruheena, Salemi, Michelle, Behrends, Christian, Phinney, Brett, Johansen, Terje, Deretic, Vojo

“…We report that lysosomal damage is a hitherto unknown inducer of stress granule (SG) formation and that the process termed membrane atg8ylation coordinates SG…”
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MERIT, a cellular system coordinating lysosomal repair, removal and replacement by Jia, Jingyue, Claude-Taupin, Aurore, Gu, Yuexi, Choi, Seong Won, Peters, Ryan, Bissa, Bhawana, Mudd, Michal H., Allers, Lee, Pallikkuth, Sandeep, Lidke, Keith A., Salemi, Michelle, Phinney, Brett, Mari, Muriel, Reggiori, Fulvio, Deretic, Vojo

“…Membrane integrity is essential for cellular survival and function. The spectrum of mechanisms protecting cellular and intracellular membranes is not fully…”
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Mammalian Atg8-family proteins are upstream regulators of the lysosomalsystem by controlling MTOR and TFEB by Kumar, Suresh, Jain, Ashish, Choi, Seong Won, Peixoto Duarte da Silva, Gustavo, Allers, Lee, Mudd, Michal H., Peters, Ryan Scott, Anonsen, Jan Haug, Rusten, Tor-Erik, Lazarou, Michael, Deretic, Vojo

“…Macroautophagy/autophagy delivers cytoplasmic cargo to lysosomes for degradation. In yeast, the single Atg8 protein plays a role in the formation of…”
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Galectins and TRIMs directly interact and orchestrate autophagic response to endomembrane damage by Kumar, Suresh, Chauhan, Santosh, Jain, Ashish, Ponpuak, Marisa, Choi, Seong Won, Mudd, Michal, Peters, Ryan, Mandell, Michael A., Johansen, Terje, Deretic, Vojo

“…Macroautophagy/autophagy is a homeostatic process delivering cytoplasmic targets, including damaged organelles, to lysosomes for degradation; however, it is…”
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Author Correction: Mammalian Atg8 proteins and the autophagy factor IRGM control mTOR and TFEB at a regulatory node critical for responses to pathogens by Kumar, Suresh, Jain, Ashish, Choi, Seong Won, da Silva, Gustavo Peixoto Duarte, Allers, Lee, Mudd, Michal H., Peters, Ryan Scott, Anonsen, Jan Haug, Rusten, Tor-Erik, Lazarou, Michael, Deretic, Vojo

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Dedicated SNAREs and specialized TRIM cargo receptors mediate secretory autophagy by Kimura, Tomonori, Jia, Jingyue, Kumar, Suresh, Choi, Seong Won, Gu, Yuexi, Mudd, Michal, Dupont, Nicolas, Jiang, Shanya, Peters, Ryan, Farzam, Farzin, Jain, Ashish, Lidke, Keith A, Adams, Christopher M, Johansen, Terje, Deretic, Vojo

“…Autophagy is a process delivering cytoplasmic components to lysosomes for degradation. Autophagy may, however, play a role in unconventional secretion of…”
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Autophagy's secret life: secretion instead of degradation by Claude-Taupin, Aurore, Jia, Jingyue, Mudd, Michal, Deretic, Vojo

“…Autophagy is conventionally described as a degradative, catabolic pathway and a tributary to the lysosomal system where the cytoplasmic material sequestered by…”
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Mammalian hybrid pre-autophagosomal structure HyPAS generates autophagosomes by Kumar, Suresh, Javed, Ruheena, Mudd, Michal, Pallikkuth, Sandeep, Lidke, Keith A., Jain, Ashish, Tangavelou, Karthikeyan, Gudmundsson, Sigurdur Runar, Ye, Chunyan, Rusten, Tor Erik, Anonsen, Jan Haug, Lystad, Alf Håkon, Claude-Taupin, Aurore, Simonsen, Anne, Salemi, Michelle, Phinney, Brett, Li, Jing, Guo, Lian-Wang, Bradfute, Steven B., Timmins, Graham S., Eskelinen, Eeva-Liisa, Deretic, Vojo

“…The biogenesis of mammalian autophagosomes remains to be fully defined. Here, we used cellular and in vitro membrane fusion analyses to show that…”
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ATG5 provides host protection acting as a switch in the atg8ylation cascade between autophagy and secretion by Wang, Fulong, Peters, Ryan, Jia, Jingyue, Mudd, Michal, Salemi, Michelle, Allers, Lee, Javed, Ruheena, Duque, Thabata L.A., Paddar, Masroor A., Trosdal, Einar S., Phinney, Brett, Deretic, Vojo

“…ATG5 is a part of the E3 ligase directing lipidation of ATG8 proteins, a process central to membrane atg8ylation and canonical autophagy. Loss of Atg5 in…”
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Membrane Atg8ylation, stress granule formation, and MTOR regulation during lysosomal damage by Jia, Jingyue, Wang, Fulong, Bhujabal, Zambarlal, Peters, Ryan, Mudd, Michal, Duque, Thabata, Allers, Lee, Javed, Ruheena, Salemi, Michelle, Behrends, Christian, Phinney, Brett, Johansen, Terje, Deretic, Vojo

“…The functions of mammalian Atg8 proteins (mATG8s) expand beyond canonical autophagy and include processes collectively referred to as Atg8ylation. Global…”
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Mammalian ATG8 proteins maintain autophagosomal membrane integrity through ESCRTs by Javed, Ruheena, Jain, Ashish, Duque, Thabata, Hendrix, Emily, Paddar, Masroor Ahmad, Khan, Sajjad, Claude‐Taupin, Aurore, Jia, Jingyue, Allers, Lee, Wang, Fulong, Mudd, Michal, Timmins, Graham, Lidke, Keith, Rusten, Tor Erik, Akepati, Prithvi Reddy, He, Yi, Reggiori, Fulvio, Eskelinen, Eeva‐Liisa, Deretic, Vojo

“…The canonical autophagy pathway in mammalian cells sequesters diverse cytoplasmic cargo within the double membrane autophagosomes that eventually convert into…”
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Cellular and molecular mechanism for secretory autophagy by Kimura, Tomonori, Jia, Jingyue, Claude-Taupin, Aurore, Kumar, Suresh, Choi, Seong Won, Gu, Yuexi, Mudd, Michal, Dupont, Nicolas, Jiang, Shanya, Peters, Ryan, Farzam, Farzin, Jain, Ashish, Lidke, Keith A., Adams, Christopher M., Johansen, Terje, Deretic, Vojo

“…Macroautophagy/autophagy plays a role in unconventional secretion of leaderless cytosolic proteins. Whether and how secretory autophagy diverges from…”
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