Search Results - "Muczynski, Vincent"

Differences in venous clot structures between hemophilic mice treated with emicizumab versus factor VIII or factor VIIIFc by Sefiane, Thibaud, Maynadié, Hortense, Ettingshausen, Carmen Escurola, Muczynski, Vincent, Heiligenstein, Xavier, Dumont, Julien, Christophe, Olivier D, Denis, Cécile V, Casari, Caterina, Lenting, Peter J

“…Recombinant factor VIII (rFVIII), rFVIIIFc and emicizumab are established treatment options in the management of hemophilia A. Each has its unique mode of…”
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Macrophage scavenger receptor SR-AI contributes to the clearance of von Willebrand factor by Wohner, Nikolett, Muczynski, Vincent, Mohamadi, Amel, Legendre, Paulette, Proulle, Valérie, Aymé, Gabriel, Christophe, Olivier D, Lenting, Peter J, Denis, Cécile V, Casari, Caterina

“…Previously, we found that LDL-receptor related protein-1 on macrophages mediated shear stress-dependent clearance of von Willebrand factor. In control…”
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Inducible localized delivery of an anti-PD-1 scFv enhances anti-tumor activity of ROR1 CAR-T cells in TNBC by Harrasser, Micaela, Gohil, Satyen Harish, Lau, Hiu, Della Peruta, Marco, Muczynski, Vincent, Patel, Dominic, Miranda, Elena, Grigoriadis, Kristiana, Grigoriadis, Anita, Granger, David, Evans, Rachel, Nathwani, Amit Chunilal

“…Chimeric antigen receptor (CAR)-T cells can induce powerful immune responses in patients with hematological malignancies but have had limited success against…”
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Soluble Siglec-5 associates to PSGL-1 and displays anti-inflammatory activity by Pepin, Marion, Mezouar, Soraya, Pegon, Julie, Muczynski, Vincent, Adam, Frédéric, Bianchini, Elsa P., Bazaa, Amine, Proulle, Valerie, Rupin, Alain, Paysant, Jerome, Panicot-Dubois, Laurence, Christophe, Olivier D., Dubois, Christophe, Lenting, Peter J., Denis, Cécile V.

“…Interactions between endothelial selectins and the leukocyte counter-receptor PSGL1 mediates leukocyte recruitment to inflammation sites. PSGL1 is highly…”
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Cellular and molecular effect of MEHP Involving LXRα in human fetal testis and ovary by Muczynski, Vincent, Lecureuil, Charlotte, Messiaen, Sébastien, Guerquin, Marie-Justine, N'tumba-Byn, Thierry, Moison, Delphine, Hodroj, Wassim, Benjelloun, Hinde, Baijer, Jan, Livera, Gabriel, Frydman, René, Benachi, Alexandra, Habert, René, Rouiller-Fabre, Virginie

“…Phthalates have been shown to have reprotoxic effects in rodents and human during fetal life. Previous studies indicate that some members of the nuclear…”
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Nuclear receptors and endocrine disruptors in fetal and neonatal testes: a gapped landscape by Rouiller-Fabre, Virginie, Guerquin, Marie Justine, N'Tumba-Byn, Thierry, Muczynski, Vincent, Moison, Delphine, Tourpin, Sophie, Messiaen, Sébastien, Habert, René, Livera, Gabriel

“…During the last decades, many studies reported that male reproductive disorders are increasing among humans. It is currently acknowledged that these…”
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In vitro effects of Uranium on human fetal germ cells by Angenard, Gaëlle, Muczynski, Vincent, Coffigny, Hervé, Duquenne, Clotilde, Frydman, René, Habert, René, Livera, Gabriel, Rouiller-Fabre, Virginie

“…Uranium (U) is found in the environment and its use in industrial or military activities has led to concerns about its potential toxicity. The reprotoxicity of…”
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Cadmium Increases Human Fetal Germ Cell Apoptosis by ANGENARD, Gaëlle, MUCZYNSKI, Vincent, COFFIGNY, Hervé, PAIRAULT, Catherine, DUQUENNE, Clotilde, FRYDMAN, René, HABERT, René, ROUILLER-FABRE, Virginie, LIVERA, Gabriel

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AAV mediated gene therapy for haemophilia B: From the early attempts to modern trials by Muczynski, Vincent, Nathwani, Amit C.

“…Early gene therapy clinical trials for the treatment of Haemophilia B have been instrumental to our global understanding of gene therapy and have significantly…”
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AAV-Mediated Expression of a Single-Chain FVIII Mimetic Antibody Efficiently Corrects Bleeding in Haemophilia a Mice by Muczynski, Vincent, Bun, Eric, Tanner, Lewis, McIntosh, Jenny H., Christophe, Olivier D., Nathwani, Amit C.

“…Background: The recent approval of gene therapy for haemophilia A (HA) using adeno-associated viruses (AAVs) marks an important and long-awaited landmark as it…”
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A next generation inducible armored CAR to overcome the immunosuppressive tumor microenvironment and enhances cytotoxicity of CAR-T and TILs by Granger, David, Harrasser, Micaela, Evans, Rachel, Muczynski, Vincent, Chester, Kerry, Nathwani, Amit C.

“…e14517 Background: The full potential of CAR-T cells in clinic is limited by the immunosuppressive tumour microenvironment (TME), which induces expression of…”
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NVG-222: A First-in-Class Autoregulating Half-Life Extended ROR1xCD3 T Cell Engager Heralding a New Class of Safer Drugs by Granger, David, Muczynski, Vincent, Henne, Patricia, Baccaro, Annalisa, Fernando, Dinusha, Shah, Mittal, Devlin, John, O'Donovan, Kieran, Nathwani, Amit C.

“…Background T cell engagers (TCEs) are realizing their promise in both liquid and solid tumours, with several approvals in the last two years and many more in…”
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A hemophilia A mouse model for the in vivo assessment of emicizumab function by Ferrière, Stephen, Peyron, Ivan, Christophe, Olivier D., Kawecki, Charlotte, Casari, Caterina, Muczynski, Vincent, Nathwani, Amit, Kauskot, Alexandre, Lenting, Peter J., Denis, Cécile V.

“…The bispecific antibody emicizumab is increasingly used for hemophilia A treatment. However, its specificity for human factors IX and X (FIX and FX) has…”
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Osteoprotegerin modulates platelet adhesion to von Willebrand factor during release from endothelial cells by Wohner, Nikolett, Sebastian, Silvie, Muczynski, Vincent, Huskens, Dana, de Laat, Bas, de Groot, Philip G, Lenting, Peter J

“…Background Platelet‐binding Von Willebrand Factor (VWF) strings assemble upon stimulated secretion from endothelial cells. Objectives To investigate the…”
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Pre-Clinical Development of a First in Class Half-Life Extended T Cell Engager Targeting ROR-1 by Granger, David, Henne, Patricia, Baccaro, Annalisa, Fernando, Dinusha, Gore, Jasmine, Gbajumo, Ephraim, Muczynski, Vincent, Shah, Mittal, O'Donovan, Kieran, Chester, Kerry, Nathwani, Amit C.

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A FVIII-Mimetic Bispecific Antibody with an Embedded Self-Regulation Mechanism Reduces the Risk of Prothrombotic Events for the Treatment of Haemophilia a by Muczynski, Vincent, Smith, Angel, Sefiane, Thibaud, Christophe, Olivier D., Lenting, Peter J., Granger, David, Chester, Kerry, Nathwani, Amit C.

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A sensitive and robust bioanalytical assay for pharmacokinetic analysis of ROR1xCD3 bispecific T cell engager (NVG-111) in a first-in-human study by Shah, Mittal, Granger, David, Bobrzynski, Tomasz, Baccaro, Annalisa, Gore, Jasmine, Muczynski, Vincent, Cook, Sarah, Chester, Kerry, Batten, Toby, O'Donovan, Kieran, Jasani, Parag, Nathwani, Amit C.

“…e19505 Background: Receptor tyrosine kinase-like Orphan Receptor-1 (ROR1) is widely expressed on hematological and solid tumors. NVG-111, a first in class…”
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The VWF/LRP4/αVβ3-axis represents a novel pathway regulating proliferation of human vascular smooth muscle cells by Lagrange, Jérémy, Worou, Morel E, Michel, Jean-Baptiste, Raoul, Alexandre, Didelot, Mélusine, Muczynski, Vincent, Legendre, Paulette, Plénat, François, Gauchotte, Guillaume, Lourenco-Rodrigues, Marc-Damien, Christophe, Olivier D, Lenting, Peter J, Lacolley, Patrick, Denis, Cécile V, Regnault, Véronique

“…Von Willebrand factor (VWF) is a plasma glycoprotein involved in primary haemostasis, while also having additional roles beyond haemostasis namely in cancer,…”
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The VWF/LRP4/aVb3-axis represents a novel pathway regulating proliferation of human vascular smooth muscle cells by Lagrange, Jérémy, Worou, Morel, Michel, Jean-Baptiste, Raoul, Alexandre, Didelot, Mélusine, Muczynski, Vincent, Legendre, Paulette, Plénat, François, Gauchotte, Guillaume, Lourenco-Rodrigues, Marc-Damien, Christophe, Olivier D, Lenting, Peter J, Lacolley, Patrick, Denis, Cécile, Regnault, Véronique

“…Aims: Von Willebrand factor (VWF) is a plasma glycoprotein involved in primary hemostasis, while also having additional roles beyond hemostasis namely in…”
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NVG-111, a novel ROR1xCD3 bispecific antibody for non-Hodgkin lymphoma by Granger, David, Gohil, Satyen, Barbarulo, Alessandro, Baccaro, Annalisa, Muczynski, Vincent, Chester, Kerry, Germaschewski, Fiona, Batten, Toby, Brown, Kathryn, Cook, Sarah, O'Donovan, Kieran, Jasani, Parag, Nathwani, Amit C., Phillips, Peter

“…Abstract only 7549 Background: Receptor tyrosine kinase-like Orphan Receptor 1 (ROR1) is a type I transmembrane protein is highly expressed on an array of…”
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