Search Results - "Mucosal immunology"

Microbes, metabolites, and the gut–lung axis by Dang, Anh Thu, Marsland, Benjamin J.

“…The microbiota plays an essential role in the education, development, and function of the immune system, both locally and systemically. Emerging experimental…”
Get full text

Perturbation of the gut microbiome by Prevotella spp. enhances host susceptibility to mucosal inflammation by Iljazovic, Aida, Roy, Urmi, Gálvez, Eric J. C., Lesker, Till R., Zhao, Bei, Gronow, Achim, Amend, Lena, Will, Sabine E., Hofmann, Julia D., Pils, Marina C., Schmidt-Hohagen, Kerstin, Neumann-Schaal, Meina, Strowig, Till

“…Diverse microbial signatures within the intestinal microbiota have been associated with intestinal and systemic inflammatory diseases, but whether these…”
Get full text

Systemic and mucosal IgA responses are variably induced in response to SARS-CoV-2 mRNA vaccination and are associated with protection against subsequent infection by Sheikh-Mohamed, Salma, Isho, Baweleta, Chao, Gary Y.C., Zuo, Michelle, Cohen, Carmit, Lustig, Yaniv, Nahass, George R., Salomon-Shulman, Rachel E., Blacker, Grace, Fazel-Zarandi, Mahya, Rathod, Bhavisha, Colwill, Karen, Jamal, Alainna, Li, Zhijie, de Launay, Keelia Quinn, Takaoka, Alyson, Garnham-Takaoka, Julia, Patel, Anjali, Fahim, Christine, Paterson, Aimee, Li, Angel Xinliu, Haq, Nazrana, Barati, Shiva, Gilbert, Lois, Green, Karen, Mozafarihashjin, Mohammad, Samaan, Philip, Budylowski, Patrick, Siqueira, Walter L., Mubareka, Samira, Ostrowski, Mario, Rini, James M., Rojas, Olga L., Weissman, Irving L., Tal, Michal Caspi, McGeer, Allison, Regev-Yochay, Gili, Straus, Sharon, Gingras, Anne-Claude, Gommerman, Jennifer L.

“…Although SARS-CoV-2 infects the upper respiratory tract, we know little about the amount, type, and kinetics of antibodies (Ab) generated in the oral cavity in…”
Get full text

IgA and the intestinal microbiota: the importance of being specific by Pabst, Oliver, Slack, Emma

“…Secretory IgA has long been a divisive molecule. Some immunologists point to the mild phenotype of IgA deficiency to justify ignoring it, while some consider…”
Get full text

Human gut-associated lymphoid tissues (GALT); diversity, structure, and function by Mörbe, Urs M., Jørgensen, Peter B., Fenton, Thomas M., von Burg, Nicole, Riis, Lene B., Spencer, Jo, Agace, William W.

“…Gut-associated lymphoid tissues (GALT) are the key antigen sampling and adaptive immune inductive sites within the intestinal wall. Human GALT includes the…”
Get full text

The lung–gut axis during viral respiratory infections: the impact of gut dysbiosis on secondary disease outcomes by Sencio, Valentin, Machado, Marina Gomes, Trottein, François

“…Bacteria that colonize the human gastrointestinal tract are essential for good health. The gut microbiota has a critical role in pulmonary immunity and host’s…”
Get full text

Aryl hydrocarbon receptor and intestinal immunity by Lamas, Bruno, Natividad, Jane M., Sokol, Harry

“…Aryl hydrocarbon receptor (AhR) is a member of the basic helix–loop–helix–(bHLH) superfamily of transcription factors, which are associated with cellular…”
Get full text

Mechanisms of inflammation-driven bacterial dysbiosis in the gut by Zeng, M Y, Inohara, N, Nuñez, G

“…The gut microbiota has diverse and essential roles in host metabolism, development of the immune system and as resistance to pathogen colonization…”
Get full text

GPR43 mediates microbiota metabolite SCFA regulation of antimicrobial peptide expression in intestinal epithelial cells via activation of mTOR and STAT3 by Zhao, Ye, Chen, Feidi, Wu, Wei, Sun, Mingming, Bilotta, Anthony J, Yao, Suxia, Xiao, Yi, Huang, Xiangsheng, Eaves-Pyles, Tonyia D, Golovko, George, Fofanov, Yuriy, D'Souza, Warren, Zhao, Qihong, Liu, Zhanju, Cong, Yingzi

“…The antimicrobial peptides (AMP) produced by intestinal epithelial cells (IEC) play crucial roles in the regulation of intestinal homeostasis by controlling…”
Get full text

The central role of the nasal microenvironment in the transmission, modulation, and clinical progression of SARS-CoV-2 infection by Gallo, Oreste, Locatello, Luca Giovanni, Mazzoni, Alessio, Novelli, Luca, Annunziato, Francesco

“…The novel coronavirus SARS-CoV-2 enters into the human body mainly through the ACE2 + TMPRSS2+ nasal epithelial cells. The initial host response to this…”
Get full text

The intestinal neuro-immune axis: crosstalk between neurons, immune cells, and microbes by Jacobson, Amanda, Yang, Daping, Vella, Madeleine, Chiu, Isaac M.

“…The gastrointestinal tract is densely innervated by a complex network of neurons that coordinate critical physiological functions. Here, we summarize recent…”
Get full text

Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR–S6K pathway by Park, J, Kim, M, Kang, S G, Jannasch, A H, Cooper, B, Patterson, J, Kim, C H

“…Microbial metabolites, such as short-chain fatty acids (SCFAs), are highly produced in the intestine and potentially regulate the immune system. We studied the…”
Get full text

Emerging roles of bile acids in mucosal immunity and inflammation by Chen, Mei Lan, Takeda, Kiyoshi, Sundrud, Mark S.

“…Bile acids are cholesterol-derived surfactants that circulate actively between the liver and ileum and that are classically recognized for emulsifying dietary…”
Get full text

Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43 by Wu, W, Sun, M, Chen, F, Cao, A T, Liu, H, Zhao, Y, Huang, X, Xiao, Y, Yao, S, Zhao, Q, Liu, Z, Cong, Y

“…Intestinal IgA, which is regulated by gut microbiota, has a crucial role in maintenance of intestinal homeostasis and in protecting the intestines from…”
Get full text

Goblet cells: multifaceted players in immunity at mucosal surfaces by Knoop, Kathryn A., Newberry, Rodney D.

“…Goblet cells (GCs) are specialized epithelial cells that line multiple mucosal surfaces and have a well-appreciated role in barrier maintenance through the…”
Get full text

Microbiome-driven allergic lung inflammation is ameliorated by short-chain fatty acids by Cait, A, Hughes, M R, Antignano, F, Cait, J, Dimitriu, P A, Maas, K R, Reynolds, L A, Hacker, L, Mohr, J, Finlay, B B, Zaph, C, McNagny, K M, Mohn, W W

“…The mammalian gastrointestinal tract harbors a microbial community with metabolic activity critical for host health, including metabolites that can modulate…”
Get full text

Animal and translational models of SARS-CoV-2 infection and COVID-19 by Johansen, M. D., Irving, A., Montagutelli, X., Tate, M. D., Rudloff, I., Nold, M. F., Hansbro, N. G., Kim, R. Y., Donovan, C., Liu, G., Faiz, A., Short, K. R., Lyons, J. G., McCaughan, G. W., Gorrell, M. D., Cole, A., Moreno, C., Couteur, D., Hesselson, D., Triccas, J., Neely, G. G., Gamble, J. R., Simpson, S. J., Saunders, B. M., Oliver, B. G., Britton, W. J., Wark, P. A., Nold-Petry, C. A., Hansbro, P. M.

“…COVID-19 is causing a major once-in-a-century global pandemic. The scientific and clinical community is in a race to define and develop effective preventions…”
Get full text

The respiratory tract microbiome and lung inflammation: a two-way street by Huffnagle, G B, Dickson, R P, Lukacs, N W

“…The lungs are not sterile or free from bacteria; rather, they harbor a distinct microbiome whose composition is driven by different ecological rules than for…”
Get full text

Cellular and functional heterogeneity of the airway epithelium by Davis, Jordan D., Wypych, Tomasz P.

“…The airway epithelium protects us from environmental insults, which we encounter with every breath. Not only does it passively filter large particles, it also…”
Get full text

Imprinting of the immune system by the microbiota early in life by Al Nabhani, Ziad, Eberl, Gérard

“…The ontogeny and maturation of the immune system is modulated by the microbiota. During fetal life, the mother’s microbiota produces compounds that are…”
Get full text