Search Results - "Muckova, L"

The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease by Hepnarova, V., Korabecny, J., Matouskova, L., Jost, P., Muckova, L., Hrabinova, M., Vykoukalova, N., Kerhartova, M., Kucera, T., Dolezal, R., Nepovimova, E., Spilovska, K., Mezeiova, E., Pham, N.L., Jun, D., Staud, F., Kaping, D., Kuca, K., Soukup, O.

“…Novel tacrine-benzyl quinolone carboxylic acid (tacrine-BQCA) hybrids were designed based on multi-target directed ligands (MTLDs) paradigm, synthesized and…”
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Oxidative stress induced by oxime reactivators of acetylcholinesterase in vitro by Muckova, L., Vanova, N., Misik, J., Herman, D., Pejchal, J., Jun, D.

“…In this study, we determined the effect of methoxime (MMB-4), asoxime (HI-6), obidoxime (LüH-6), trimedoxime (TMB-4), and pralidoxime (2-PAM) on redox…”
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A 7-methoxytacrine-4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication by Nepovimova, E, Korabecny, J, Dolezal, R, Nguyen, T D, Jun, D, Soukup, O, Pasdiorova, M, Jost, P, Muckova, L, Malinak, D, Gorecki, L, Musilek, K, Kuca, Kamil

“…Chemical warfare agents constitute an increasing threat to both military and civilian populations. Therefore, effective prophylactic approaches are urgently…”
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In vitro characterization of acetylcholinesterase reactivators: The cytotoxicity and oxidative stress induction by Muckova, L., Jost, P., Pejchal, J., Jun, D.

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Biological mechanisms of sulfur mustard toxicity: Dose and time-dependent study by Jost, P., Muckova, L., Pejchal, J., Jun, D., Stetina, R.

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A 7-methoxytacrine-4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxicationElectronic supplementary information (ESI) available: Experimental procedures and characterization of all compounds. See DOI: 10.1039/c6tx00130k by Nepovimova, E, Korabecny, J, Dolezal, R, Nguyen, T. D, Jun, D, Soukup, O, Pasdiorova, M, Jost, P, Muckova, L, Malinak, D, Gorecki, L, Musilek, K, Kuca, Kamil

“…Chemical warfare agents constitute an increasing threat to both military and civilian populations. Therefore, effective prophylactic approaches are urgently…”
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A 7-methoxytacrine–4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication† †Electronic supplementary information (ESI) available: Experimental procedures and characterization of all compounds. See DOI: 10.1039/c6tx00130k by Nepovimova, E., Korabecny, J., Dolezal, R., Nguyen, T. D., Jun, D., Soukup, O., Pasdiorova, M., Jost, P., Muckova, L., Malinak, D., Gorecki, L., Musilek, K., Kuca, Kamil

“…A novel hybrid able to protect organophosphate-inhibited AChE as well as to reactivate it. Chemical warfare agents constitute an increasing threat to both…”
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