Search Results - "Muckenthaler, M"

HFE and ALK3 act in the same signaling pathway by Traeger, L., Schnittker, J., Dogan, D.Y., Oguama, D., Kuhlmann, T., Muckenthaler, M.U., Krijt, J., Urzica, E.I., Steinbicker, A.U.

“…Hepcidin deficiency leads to iron overload by increased dietary iron uptake and iron release from storage cells. The most frequent mutation in Hfe leads to…”
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The favorable effect of activating NOTCH1 receptor mutations on long-term outcome in T-ALL patients treated on the ALL–BFM 2000 protocol can be separated from FBXW7 loss of function by Kox, C, Zimmermann, M, Stanulla, M, Leible, S, Schrappe, M, Ludwig, W-D, Koehler, R, Tolle, G, Bandapalli, O R, Breit, S, Muckenthaler, M U, Kulozik, A E

“…Precursor T-cell acute lymphoblastic leukemia (T-ALL) remains an important challenge in pediatric oncology. Because of the particularly poor prognosis of…”
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Maternal iron status in early pregnancy and DNA methylation in offspring: an epigenome-wide meta-analysis by Taeubert, M J, de Prado-Bert, P, Geurtsen, M L, Mancano, G, Vermeulen, M J, Reiss, I K M, Caramaschi, D, Sunyer, J, Sharp, G C, Julvez, J, Muckenthaler, M U, Felix, J F

“…Unbalanced iron homeostasis in pregnancy is associated with an increased risk of adverse birth and childhood health outcomes. DNA methylation has been…”
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Identification of a genetically defined ultra-high-risk group in relapsed pediatric T-lymphoblastic leukemia by Richter-Pechańska, P, Kunz, J B, Hof, J, Zimmermann, M, Rausch, T, Bandapalli, O R, Orlova, E, Scapinello, G, Sagi, J C, Stanulla, M, Schrappe, M, Cario, G, Kirschner-Schwabe, R, Eckert, C, Benes, V, Korbel, J O, Muckenthaler, M U, Kulozik, A E

“…In the search for genes that define critical steps of relapse in pediatric T-cell acute lymphoblastic leukemia (T-ALL) and can serve as prognostic markers, we…”
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Efficacy and safety of deferasirox in non-thalassemic patients with elevated ferritin levels after allogeneic hematopoietic stem cell transplantation by Jaekel, N, Lieder, K, Albrecht, S, Leismann, O, Hubert, K, Bug, G, Kröger, N, Platzbecker, U, Stadler, M, de Haas, K, Altamura, S, Muckenthaler, M U, Niederwieser, D, Al-Ali, H K

“…Elevated serum ferritin contributes to treatment-related morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). The…”
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A new paradigm to understand and treat diabetic neuropathy by Hidmark, A, Fleming, T, Vittas, S, Mendler, M, Deshpande, D, Groener, J B, Müller, B P, Reeh, P W, Sauer, S K, Pham, M, Muckenthaler, M U, Bendszus, M, Nawroth, P P

“…The clinical symptoms of diabetic neuropathy (DN) manifest in a time dependent manner as a positive symptoms (i. e. pain, hypersensitivity, tingling, cramps,…”
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Iron accelerates cardiovascular disease: The importance of maintaining iron balance by Vinchi, F, Simmelbauer, A, Altamura, S, Galy, B, Hentze, M.W, Muckenthaler, M

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Heme controls ferroportin1 (FPN1) transcription involving Bach1, Nrf2 and a MARE/ARE sequence motif at position −7007 of the FPN1 promoter by MARRO, Samuele, CHIABRANDO, Deborah, MESSANA, Erika, STOLTE, Jens, TURCO, Emilia, TOLOSANO, Emanuela, MUCKENTHALER, Martina U

“…Macrophages of the reticuloendothelial system play a key role in recycling iron from hemoglobin of senescent or damaged erythrocytes. Heme oxygenase 1 degrades…”
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S108: PEDIATRIC T‐ ALL RELAPSE: CONSTITUTIONAL CANCER PREDISPOSITION AND HYPERMUTATATOR PHENOTYPES by Richter‐Pechanska, P., Kunz, J., Rausch, T., Erarslan‐Uysal, B., Bornhauser, B., Frismantas, V., Assenov, Y., Zimmermann, M., Happich, M., Knebel‐Doeberitz, C., Neuhoff, N., Koehler, R., Stanulla, M., Schrappe, M., Cario, G., Escherich, G., Kischner‐Schwabe, R., Eckert, C., Avigad, S., Pfister, S., Muckenthaler, M., Bourquin, J.‐P., Korbel, J., Kulozik, A.

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S277: HYPOFERREMIA CAUSED BY FERROPORTIN DOWNREGULATION IS REGULATED BY NFКB THROUGH HDAC‐DEPENDENT MECHANISMS by Marques, O., Horvat, N., Lai, M. C., Zechner, L., Colucci, S., Sparla, R., Zimmermann, S., Neufeldt, C. J., Altamura, S., Zaugg, J., Mudder, K., Knopf, J. D., Lemberg, M. K., Pasparakis, M., Hentze, M. W., Muckenthaler, M. U.

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S274: A NOVEL SUBTYPE OF ANEMIA CAUSED BY MUTATIONS IN TFRC GENE by Colucci, S., Venturi, V., Nicole, F., Jové Solavera, D., Zimon, M., Richter‐Pechanska, P., Hernandez, G., Unal, S., Gumruk, F., Diaz‐Conradi, A., Romero‐Cortadellas, L., Ferrer‐Cortès, X., Olivella, M., Erlacher, M., Niemeyer, C., Wiesel, T., Pepperkok, R., Fleming, M. D., Kulozik, A. E., Sanchez, M., Muckenthaler, M. U.

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Hereditary hyperferritinemia cataract syndrome--the first family in Germany by Millonig, G, Holzer, M P, Tolle, G, Auffarth, G U, Muckenthaler, M U, Seitz, H K, Mueller, S

“…We report on a 23-year-old woman who presented with elevated serum ferritin values at our department. She had undergone cataract surgery at the age of 14 and…”
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Cystic Fibrosis (CF) Newborn Screening (NBS) – Comparison of an IRT-PAP with an IRT-DNA based protocol in a German population by Sommerburg, O, Lindner, M, Muckenthaler, M, Mall, M.A, Kulozik, A, Hoffmann, G.F

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HFE Downregulates Iron Uptake From Transferrin and Induces Iron-Regulatory Protein Activity in Stably Transfected Cells by Riedel, H.D., Muckenthaler, M.U., Gehrke, S.G., Mohr, I., Brennan, K., Herrmann, T., Fitscher, B.A., Hentze, M.W., Stremmel, W.

“…Hereditary hemochromatosis (HH) is a common autosomal-recessive disorder of iron metabolism. More than 80% of HH patients are homozygous for a point mutation…”
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Comparison of fluorescent tag DNA labeling methods used for expression analysis by DNA microarrays by Richter, A, Schwager, C, Hentze, S, Ansorge, W, Hentze, M W, Muckenthaler, M

“…Gene expression profiling by DNA microarrays has found wide application in many fields of biomedical research. The protocols for this technique are not yet…”
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Iron refractory iron deficiency anemia by De Falco, Luigia, Sanchez, Mayka, Silvestri, Laura, Kannengiesser, Caroline, Muckenthaler, Martina U, Iolascon, Achille, Gouya, Laurent, Camaschella, Clara, Beaumont, Carole

“…Iron refractory iron deficiency anemia is a hereditary recessive anemia due to a defect in the TMPRSS6 gene encoding Matriptase-2. This protein is a…”
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The murine growth differentiation factor 15 is not essential for systemic iron homeostasis in phlebotomized mice by Casanovas, Guillem, Vujić Spasic, Maja, Casu, Carla, Rivella, Stefano, Strelau, Jens, Unsicker, Klaus, Muckenthaler, Martina U

“…In conditions of increased erythropoiesis, expression of hepcidin, the master regulator of systemic iron homeostasis, is decreased to allow for the release of…”
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The activating STAT5B N642H mutation is a common abnormality in pediatric T-cell acute lymphoblastic leukemia and confers a higher risk of relapse by Bandapalli, Obul R, Schuessele, Stephanie, Kunz, Joachim B, Rausch, Tobias, Stütz, Adrian M, Tal, Noa, Geron, Ifat, Gershman, Nava, Izraeli, Shai, Eilers, Juliane, Vaezipour, Nina, Kirschner-Schwabe, Renate, Hof, Jana, von Stackelberg, Arend, Schrappe, Martin, Stanulla, Martin, Zimmermann, Martin, Koehler, Rolf, Avigad, Smadar, Handgretinger, Rupert, Frismantas, Viktoras, Bourquin, Jean Pierre, Bornhauser, Beat, Korbel, Jan O, Muckenthaler, Martina U, Kulozik, Andreas E

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Hepcidin is regulated by promoter-associated histone acetylation and HDAC3 by Pasricha, Sant-Rayn, Lim, Pei Jin, Duarte, Tiago L., Casu, Carla, Oosterhuis, Dorenda, Mleczko-Sanecka, Katarzyna, Suciu, Maria, Da Silva, Ana Rita, Al-Hourani, Kinda, Arezes, João, McHugh, Kirsty, Gooding, Sarah, Frost, Joe N., Wray, Katherine, Santos, Ana, Porto, Graça, Repapi, Emmanouela, Gray, Nicki, Draper, Simon J., Ashley, Neil, Soilleux, Elizabeth, Olinga, Peter, Muckenthaler, Martina U., Hughes, Jim R., Rivella, Stefano, Milne, Thomas A., Armitage, Andrew E., Drakesmith, Hal

“…Hepcidin regulates systemic iron homeostasis. Suppression of hepcidin expression occurs physiologically in iron deficiency and increased erythropoiesis but is…”
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Pediatric T-cell lymphoblastic leukemia evolves into relapse by clonal selection, acquisition of mutations and promoter hypomethylation by Kunz, Joachim B, Rausch, Tobias, Bandapalli, Obul R, Eilers, Juliane, Pechanska, Paulina, Schuessele, Stephanie, Assenov, Yassen, Stütz, Adrian M, Kirschner-Schwabe, Renate, Hof, Jana, Eckert, Cornelia, von Stackelberg, Arend, Schrappe, Martin, Stanulla, Martin, Koehler, Rolf, Avigad, Smadar, Elitzur, Sarah, Handgretinger, Rupert, Benes, Vladimir, Weischenfeldt, Joachim, Korbel, Jan O, Muckenthaler, Martina U, Kulozik, Andreas E

“…Relapsed precursor T-cell acute lymphoblastic leukemia is characterized by resistance against chemotherapy and is frequently fatal. We aimed at understanding…”
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