Search Results - "Muchenditsi, Abigael"

Copper Capture in a Thioether-Functionalized Porous Polymer Applied to the Detection of Wilson’s Disease by Lee, Sumin, Barin, Gokhan, Ackerman, Cheri M, Muchenditsi, Abigael, Xu, Jun, Reimer, Jeffrey A, Lutsenko, Svetlana, Long, Jeffrey R, Chang, Christopher J

“…Copper is an essential nutrient for life, but at the same time, hyperaccumulation of this redox-active metal in biological fluids and tissues is a hallmark of…”
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Systemic deletion of Atp7b modifies the hepatocytes’ response to copper overload in the mouse models of Wilson disease by Muchenditsi, Abigael, Talbot, C. Conover, Gottlieb, Aline, Yang, Haojun, Kang, Byunghak, Boronina, Tatiana, Cole, Robert, Wang, Li, Dev, Som, Hamilton, James P., Lutsenko, Svetlana

“…Wilson disease (WD) is caused by inactivation of the copper transporter Atp7b and copper overload in tissues. Mice with Atp7b deleted either globally (systemic…”
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Activation of liver X receptor/retinoid X receptor pathway ameliorates liver disease in Atp7B−/− (Wilson disease) mice by Hamilton, James P., Koganti, Lahari, Muchenditsi, Abigael, Pendyala, Venkata S., Huso, David, Hankin, Joseph, Murphy, Robert C., Huster, Dominik, Merle, Uta, Mangels, Christopher, Yang, Nan, Potter, James J., Mezey, Esteban, Lutsenko, Svetlana

“…Wilson disease (WD) is a hepatoneurological disorder caused by mutations in the copper‐transporter, ATP7B. Copper accumulation in the liver is a hallmark of…”
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Urinary copper elevation in a mouse model of Wilson's disease is a regulated process to specifically decrease the hepatic copper load by Gray, Lawrence W, Peng, Fangyu, Molloy, Shannon A, Pendyala, Venkata S, Muchenditsi, Abigael, Muzik, Otto, Lee, Jaekwon, Kaplan, Jack H, Lutsenko, Svetlana

“…Body copper homeostasis is regulated by the liver, which removes excess copper via bile. In Wilson's disease (WD), this function is disrupted due to…”
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Systemic Deletion of Atp7b Modifies the Hepatocytes’ Response to Copper Overload in the Mouse Models of Wilson Disease by Muchenditsi, Abigael

“…Wilson disease (WD) is a genetic disorder caused by inactivation of the copper (Cu) transporter Atp7b and Cu overload, especially in the liver. Mice with Atp7b…”
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The Function of ATPase Copper Transporter ATP7B in Intestine by Pierson, Hannah, Muchenditsi, Abigael, Kim, Byung-Eun, Ralle, Martina, Zachos, Nicholas, Huster, Dominik, Lutsenko, Svetlana

“…Wilson disease is a disorder of copper (Cu) misbalance caused by mutations in ATP7B. ATP7B is highly expressed in the liver—the major site of Cu accumulation…”
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Copper regulates cyclic-AMP-dependent lipolysis by Krishnamoorthy, Lakshmi, Cotruvo, Joseph A, Chan, Jefferson, Kaluarachchi, Harini, Muchenditsi, Abigael, Pendyala, Venkata S, Jia, Shang, Aron, Allegra T, Ackerman, Cheri M, Wal, Mark N Vander, Guan, Timothy, Smaga, Lukas P, Farhi, Samouil L, New, Elizabeth J, Lutsenko, Svetlana, Chang, Christopher J

“…Biochemical analysis, and imaging using a copper-sensitive fluorescent sensor, demonstrate that copper regulates cAMP-mediated lipolysis by inhibiting the…”
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ATP7A and ATP7B copper transporters have distinct functions in the regulation of neuronal dopamine-β-hydroxylase by Schmidt, Katharina, Ralle, Martina, Schaffer, Thomas, Jayakanthan, Samuel, Bari, Bilal, Muchenditsi, Abigael, Lutsenko, Svetlana

“…The copper (Cu) transporters ATPase copper-transporting alpha (ATP7A) and ATPase copper-transporting beta (ATP7B) are essential for the normal function of the…”
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Targeted inactivation of copper transporter Atp7b in hepatocytes causes liver steatosis and obesity in mice by Muchenditsi, Abigael, Yang, Haojun, Hamilton, James P, Koganti, Lahari, Housseau, Franck, Aronov, Lisa, Fan, Hongni, Pierson, Hannah, Bhattacharjee, Ashima, Murphy, Robert, Sears, Cynthia, Potter, James, Wooton-Kee, Clavia R, Lutsenko, Svetlana

“…Copper-transporting ATPase 2 (ATP7B) is essential for mammalian copper homeostasis. Mutations in result in copper accumulation, especially in the liver, and…”
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Localization of the Locus Coeruleus in the Mouse Brain by Schmidt, Katharina, Bari, Bilal, Ralle, Martina, Washington-Hughes, Clorissa, Muchenditsi, Abigael, Maxey, Evan, Lutsenko, Svetlana

“…The locus coeruleus (LC) is a major hub of norepinephrine producing neurons that modulate a number of physiological functions. Structural or functional…”
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Changes in mammalian copper homeostasis during microbial infection by Culbertson, Edward M, Khan, Aslam A, Muchenditsi, Abigael, Lutsenko, Svetlana, Sullivan, David J, Petris, Michael J, Cormack, Brendan P, Culotta, Valeria C

“…Animals carefully control homeostasis of Cu, a metal that is both potentially toxic and an essential nutrient. During infection, various shifts in Cu…”
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Relation of Copper Toxicosis in Dogs and Wilson Disease to the Appearance of a Small Copper Carrier (SCC) in Blood Plasma and Urine by Flynn, Stephen, Dalphin, Matthew, Tellez, Miguel, Fieten, Hille, Weldy, Scott, Muchenditsi, Abigael, Lutsenko, Svetlana, Linder, Maria

“…Abstract only The main route for copper excretion in mammals is via the bile, little exiting through urine. In Wilson disease, biliary excretion is prevented…”
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Copper Capture in a Thioether-Functionalized Porous Polymer Applied to the Detection of Wilson’s Disease by Lee, Sumin, Barin, Gokhan, Ackerman, Cheri M., Muchenditsi, Abigael, Xu, Jun, Reimer, Jeffrey A., Lutsenko, Svetlana, Long, Jeffrey R., Chang, Christopher J.

“…Copper is an essential nutrient for life, but at the same time, hyperaccumulation of this redox-active metal in biological fluids and tissues is a hallmark of…”
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Oxysterol misbalance critically contributes to Wilson disease pathogenesis by Dev, Som, Muchenditsi, Abigael, Gottlieb, Aline, Deme, Pragney, Murphy, Sean, Gabrielson, Kathleen L, Dong, Yixuan, Hughes, Robert, Haughey, Norman J, Hamilton, James P, Lutsenko, Svetlana

“…Wilson disease (WD) is a metabolic disorder caused by inactivation of the copper-transporting ATPase 2 (ATP7B) and copper (Cu) overload in tissues. Excess Cu…”
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Activation of liver X receptor/retinoid X receptor pathway ameliorates liver disease in Atp7B super(-/-) (Wilson disease) mice by Hamilton, James P, Koganti, Lahari, Muchenditsi, Abigael, Pendyala, Venkata S, Huso, David, Hankin, Joseph, Murphy, Robert C, Huster, Dominik, Merle, Uta, Mangels, Christopher, Yang, Nan, Potter, James J, Mezey, Esteban, Lutsenko, Svetlana

“…Wilson disease (WD) is a hepatoneurological disorder caused by mutations in the copper-transporter, ATP7B. Copper accumulation in the liver is a hallmark of…”
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Structural Probing of the T Box Antiterminator-tRNA Complex by Hines, Jennifer, Means, John A., Muchenditsi, Abigael, Agyeman, Akwasi

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Identification of neomycin B-binding site in T box antiterminator model RNA by Anupam, Rajaneesh, Denapoli, Leyna, Muchenditsi, Abigael, Hines, Jennifer V.

“…The T box antiterminator model RNA, AM1A, and neomycin B with binding site localized to the 5′ end of the bulge. The T box transcription antitermination…”
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Effects of metal ions and loop stability on the structure and function of the T box antiterminator RNA and its complex with model tRNA by Muchenditsi, Abigael M

“…The T box antitermination mechanism is a novel transcription regulatory system found in many Gram-positive bacteria. The mechanism serves to regulate aminoacyl…”
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Effects of metal ions and loop stability on the structure and function of the T box antiterminator RNA and its complex with model tRNA by Muchenditsi, Abigael M

“…The T box antitermination mechanism is a novel transcription regulatory system found in many Gram-positive bacteria. The mechanism serves to regulate aminoacyl…”
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