Search Results - "Mucha, Artur"

Synthesis and modifications of phosphinic dipeptide analogues by Mucha, Artur

“…Pseudopeptides containing the phosphinate moiety (-P(O)(OH)CH(2)-) have been studied extensively, mainly as transition state analogue inhibitors of…”
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Antibacterial Activity of Ebselen by Maślanka, Marta, Mucha, Artur

“…Ebselen is a low-molecular-weight organoselenium compound that has been broadly studied for its antioxidant, anti-inflammatory, and cytoprotective properties…”
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Recent developments in the synthesis and applications of phosphinic peptide analogs by Talma, Michał, Maślanka, Marta, Mucha, Artur

“…[Display omitted] •Phosphinic peptides are transition state inhibitors of Zn-proteases and ligases.•Binding to the active sites involves metal complexation and…”
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P1' Residue-Oriented Virtual Screening for Potent and Selective Phosphinic (Dehydro) Dipeptide Inhibitors of Metallo-Aminopeptidases by Talma, Michał, Mucha, Artur

“…Designing side chain substituents complementary to enzyme binding pockets is of great importance in the construction of potent and selective phosphinic…”
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Recent Developments in Peptidyl Diaryl Phoshonates as Inhibitors and Activity-Based Probes for Serine Proteases by Maślanka, Marta, Mucha, Artur

“…This review presents current achievements in peptidyl diaryl phosphonates as covalent, specific mechanism-based inhibitors of serine proteases. Along three…”
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N -Benzyl Residues as the P1' Substituents in Phosphorus-Containing Extended Transition State Analog Inhibitors of Metalloaminopeptidases by Janiszewska, Kamila, Talma, Michał, Oszywa, Bartosz, Pawełczak, Małgorzata, Kafarski, Paweł, Mucha, Artur

“…Peptidyl enzyme inhibitors containing an internal aminomethylphosphinic bond system (P(O)(OH)-CH -NH) can be termed extended transition state analogs by…”
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A tribute to Prof. Pawel Kafarski by Mucha, Artur

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Aminophosphinates against Helicobacter pylori ureolysis-Biochemical and whole-cell inhibition characteristics by Macegoniuk, Katarzyna, Grela, Ewa, Biernat, Monika, Psurski, Mateusz, Gościniak, Grażyna, Dziełak, Anna, Mucha, Artur, Wietrzyk, Joanna, Berlicki, Łukasz, Grabowiecka, Agnieszka

“…Urease is an important virulence factor from Helicobacter pylori that enables bacterial colonization of human gastric mucosa. Specific inhibition of urease…”
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Bis(aminomethyl)phosphinic Acid, a Highly Promising Scaffold for the Development of Bacterial Urease Inhibitors by Macegoniuk, Katarzyna, Dziełak, Anna, Mucha, Artur, Berlicki, Łukasz

“…Inhibitors of bacterial ureases are considered to be promising compounds in the treatment of infections caused by Helicobacter pylori in the gastric tract…”
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P-C bond formation in reactions of Morita-Baylis-Hillman adducts with phosphorus nucleophiles by Talma, Michał, Mucha, Artur

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Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase by McGowan, Sheena, Porter, Corrine J, Lowther, Jonathan, Stack, Colin M, Golding, Sarah J, Skinner-Adams, Tina S, Trenholme, Katharine R, Teuscher, Franka, Donnelly, Sheila M, Grembecka, Jolanta, Mucha, Artur, Kafarski, Pawel, DeGori, Ross, Buckle, Ashley M, Gardiner, Donald L, Whisstock, James C, Dalton, John P

“…Plasmodium falciparum parasites are responsible for the major global disease malaria, which results in >2 million deaths each year. With the rise of…”
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Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases by McGowan, Sheena, Oellig, Christine A, Birru, Woldeamanuel A, Caradoc-Davies, Tom T, Stack, Colin M, Lowther, Jonathan, Skinner-Adams, Tina, Mucha, Artur, Kafarski, Pawel, Grembecka, Jolanta, Trenholme, Katharine R, Buckle, Ashley M, Gardiner, Donald L, Dalton, John P, Whisstock, James C

“…Current therapeutics and prophylactics for malaria are under severe challenge as a result of the rapid emergence of drug-resistant parasites. The human malaria…”
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Diethyl boronobenzylphosphonates as substrates in Petasis reaction by Rydzewska, Agata, Olender, Anna, Mucha, Artur, Kafarski, Paweł

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Identification of Phosphinate Dipeptide Analog Inhibitors Directed against the Plasmodium falciparum M17 Leucine Aminopeptidase as Lead Antimalarial Compounds by Skinner-Adams, Tina S, Lowther, Jonathan, Teuscher, Franka, Stack, Colin M, Grembecka, Jolanta, Mucha, Artur, Kafarski, Pawel, Trenholme, Katharine R, Dalton, John P, Gardiner, Donald L

“…Previous studies have pinpointed the M17 leucyl aminopeptidase of Plasmodium falciparum (PfLAP) as a target for the development of new antimalarials. This…”
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Addition of H-phosphonates to quinine-derived carbonyl compounds. An unexpected C9 phosphonate-phosphate rearrangement and tandem intramolecular piperidine elimination by Górecki, Lukasz, Mucha, Artur, Kafarski, Paweł

“…The Abramov reaction, a base-catalyzed nucleophilic addition of dialkyl H-phosphonates (phosphites) to carbonyl compounds, was performed with oxidized quinine…”
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Individual stereoisomers of phosphinic dipeptide inhibitor of leucine aminopeptidase by Mucha, Artur, Lämmerhofer, Michael, Lindner, Wolfgang, Pawełczak, Małgorzata, Kafarski, Paweł

“…First successful separation of all four stereoisomers of a phosphinic acid pseudodipeptide allowed to determine the inhibitory activity of the…”
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The M18 Aspartyl Aminopeptidase of the Human Malaria Parasite Plasmodium falciparum by Teuscher, Franka, Lowther, Jonathan, Skinner-Adams, Tina S., Spielmann, Tobias, Dixon, Matthew W.A., Stack, Colin M., Donnelly, Sheila, Mucha, Artur, Kafarski, Paweł, Vassiliou, Stamatia, Gardiner, Donald L., Dalton, John P., Trenholme, Katharine R.

“…A member of the M18 family of aspartyl aminopeptidases is expressed by all intra-erythrocytic stages of the human malaria parasite Plasmodium falciparum…”
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A synthetic method for diversification of the P1′ substituent in phosphinic dipeptides as a tool for exploration of the specificity of the S1′ binding pockets of leucine aminopeptidases by Vassiliou, Stamatia, Xeilari, Metaxia, Yiotakis, Athanasios, Grembecka, Jolanta, Pawełczak, Małgorzata, Kafarski, Paweł, Mucha, Artur

“…A novel, general, and versatile method of diversification of the P1′ position in phosphinic pseudodipeptides, presumable inhibitors of proteolytic enzymes, was…”
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Remarkable Potential of the α-Aminophosphonate/Phosphinate Structural Motif in Medicinal Chemistry by Mucha, Artur, Kafarski, Paweł, Berlicki, Łukasz

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Peptide and Pseudopeptide Bond Synthesis in Phosphorus Dipeptide Analogs by Mucha, Artur, Kafarski, Paweł

“…Peptide analogs modified with a phosphorus-based moiety (phosphonate, phosphonamidate, or phosphinate) have emerged as invaluable tools in fundamental and…”
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