Search Results - "Muccio, D"

A Small Molecule, UAB126, Reverses Diet-Induced Obesity and its Associated Metabolic Disorders by Ren, Guang, Kim, Teayoun, Kim, Hae-Suk, Young, Martin E, Muccio, Donald D, Atigadda, Venkatram R, Blum, Samuel I, Tse, Hubert M, Habegger, Kirk M, Bhatnagar, Sushant, Coric, Tatjana, Bjornsti, Mary-Ann, Shalev, Anath, Frank, Stuart J, Kim, Jeong-A

“…Targeting retinoid X receptor (RXR) has been proposed as one of the therapeutic strategies to treat individuals with metabolic syndrome, as RXR heterodimerizes…”
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Retinoid X Receptor Agonists Upregulate Genes Responsible for the Biosynthesis of All-Trans-Retinoic Acid in Human Epidermis by Wu, Lizhi, Chaudhary, Sandeep C, Atigadda, Venkatram R, Belyaeva, Olga V, Harville, Steven R, Elmets, Craig A, Muccio, Donald D, Athar, Mohammad, Kedishvili, Natalia Y

“…UAB30 is an RXR selective agonist that has been shown to have potential cancer chemopreventive properties. Due to high efficacy and low toxicity, it is…”
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Methyl Substitution of a Rexinoid Agonist Improves Potency and Reveals Site of Lipid Toxicity by Atigadda, Venkatram R, Xia, Gang, Desphande, Anil, Boerma, LeeAnn J, Lobo-Ruppert, Susan, Grubbs, Clinton J, Smith, Craig D, Brouillette, Wayne J, Muccio, Donald D

“…(2E,4E,6Z,8E)-8-(3′,4′-Dihydro-1′(2′H)-naphthalen-1′-ylidene)-3,7-dimethyl-2,4,6-octatrienoic acid, 9cUAB30, is a selective rexinoid that displays substantial…”
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Translation of a Tissue-Selective Rexinoid, UAB30, to the Clinic for Breast Cancer Prevention by Muccio, Donald D, Atigadda, Venkatram R, Brouillette, Wayne J, Bland, Kirby I, Krontiras, Helen, Grubbs, Clinton J

“…This review focuses on our efforts to translate a low-toxicity retinoid X receptor-selective agonist, UAB30, to the clinic for the prevention of breast…”
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Effects on gene expression in rat liver after administration of RXR agonists: UAB30, 4-methyl-UAB30, and Targretin (Bexarotene) by Vedell, Peter T, Lu, Yan, Grubbs, Clinton J, Yin, Yuxin, Jiang, Hui, Bland, Kirby I, Muccio, Donald D, Cvetkovic, Dusica, You, Ming, Lubet, Ronald

“…Examination of three retinoid X receptor (RXR) agonists [Targretin (TRG), UAB30, and 4-methyl-UAB30 (4-Me-UAB30)] showed that all inhibited mammary cancer in…”
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The retinoid X receptor agonist, 9-cis UAB30, inhibits cutaneous T-cell lymphoma proliferation through the SKP2-p27kip1 axis by Chou, Chu-Fang, Hsieh, Yu-Hua, Grubbs, Clinton J., Atigadda, Venkatram R., Mobley, James A., Dummer, Reinhard, Muccio, Donald D., Eto, Isao, Elmets, Craig A., Garvey, W. Timothy, Chang, Pi-Ling

“…•9-cis UA30 (UAB30) induces apoptosis and suppresses proliferation in CTCL cells.•Inhibition of G1 cell-cycle checkpoint by UAB30 involves the SKP2-p27kip1…”
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Methyl-substituted conformationally constrained rexinoid agonists for the retinoid X receptors demonstrate improved efficacy for cancer therapy and prevention by Desphande, Anil, Xia, Gang, Boerma, LeeAnn J., Vines, Kimberly K., Atigadda, Venkatram R., Lobo-Ruppert, Susan, Grubbs, Clinton J., Moeinpour, Fariba L., Smith, Craig D., Christov, Konstantin, Brouillette, Wayne J., Muccio, Donald D.

“…(2E,4E,6Z,8Z)-8-(3′,4′-Dihydro-1′(2H)-naphthalen-1′-ylidene)-3,7-dimethyl-2,3,6-octatrienoinic acid, 9cUAB30, is a selective rexinoid for the retinoid X…”
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Rescuing Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)-Processing Mutants by Transcomplementation by Cormet-Boyaka, Estelle, Jablonsky, Michael, Naren, Anjaparavanda P., Jackson, Patricia L., Muccio, Donald D., Kirk, Kevin L., Sabatini, David D.

“…Most cases of cystic fibrosis (CF) are caused by mutations that block the biosynthetic maturation of the CF gene product, the CF transmembrane conductance…”
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Stability of the Retinoid X Receptor‑α Homodimer in the Presence and Absence of Rexinoid and Coactivator Peptide by Yang, Zhengrong, Muccio, Donald D, Melo, Nathalia, Atigadda, Venkatram R, Renfrow, Matthew B

“…Differential scanning calorimetry and differential scanning fluorimetry were used to measure the thermal stability of human retinoid X receptor-α ligand…”
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Prevention of KLF4-mediated tumor initiation and malignant transformation by UAB30 rexinoid by Jiang, Wen, Deng, Wentao, Bailey, Sarah, Nail, Clint D., Frost, Andra R., Brouillette, Wayne J., Muccio, Donald D., Grubbs, Clinton J., Lobo-ruppert, Susan M, Ruppert, J. Michael

“…The transcription factor KLF4 functions in post-mitotic epithelial cells to promote differentiation, and functions in a context-dependent fashion as an…”
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Next-generation retinoid X receptor agonists increase ATRA signaling in organotypic epithelium cultures and have distinct effects on receptor dynamics by Melo, Nathalia, Belyaeva, Olga V., Berger, Wilhelm K., Halasz, Laszlo, Yu, Jianshi, Pilli, Nagesh, Yang, Zhengrong, Klyuyeva, Alla V., Elmets, Craig A., Atigadda, Venkatram, Muccio, Donald D., Kane, Maureen A., Nagy, Laszlo, Kedishvili, Natalia Y., Renfrow, Matthew B.

“…Retinoid X receptors (RXRs) are nuclear transcription factors that partner with other nuclear receptors to regulate numerous physiological processes. Although…”
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In Vitro Metabolic Characterization, Phenotyping, and Kinetic Studies of 9cUAB30, a Retinoid X Receptor-Specific Retinoid by GORMAN, Gregory S, COWARD, Lori, KERSTNER-WOOD, Corenna, CORK, Lea, KAPETANOVIC, Izet M, BROUILLETTE, Wayne J, MUCCIO, Donald D

“…The present study was conducted to compare the in vitro phase I and phase II metabolic profiles of (2 E ,4 E ,6 Z ,8 E )-8-(3′,4′-dihydro-1′(2′ H…”
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Expression of crustacean ( Callinectes sapidus) molt-inhibiting hormone in Escherichia coli: Characterization of the recombinant peptide and assessment of its effects on cellular signaling pathways in Y-organs by Nakatsuji, Teruaki, Han, Deug-Woo, Jablonsky, Michael J., Harville, Steven R., Muccio, Donald D., Watson, R. Douglas

“…A neuropeptide, molt-inhibiting hormone (MIH), negatively regulates the synthesis of ecdysteroid molting hormones by crustacean Y-organs. We report here the…”
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Conformationally Defined Rexinoids for the Prevention of Inflammation and Nonmelanoma Skin Cancers by Atigadda, Venkatram R., Kashyap, Mahendra P., Yang, Zhengrong, Chattopadhyay, Debasish, Melo, Nathalia, Sinha, Rajesh, Belyaeva, Olga V., Chou, Chu-Fang, Chang, Pi-Ling, Kedishvili, Natalia Y., Grubbs, Clinton J., Renfrow, Matthew B., Muccio, Donald D., Elmets, Craig A., Athar, Mohammad

“…Compound 1 is a potent rexinoid that is highly effective in cancer chemoprevention but elevates serum triglycerides. In an effort to separate the lipid…”
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Biochemical characterization and crystallization of recombinant 3-phosphoglycerate kinase of Plasmodium falciparum by Pal, Biswajit, Pybus, Brandon, Muccio, Donald D., Chattopadhyay, Debasish

“…Human malaria parasite Plasmodium falciparum depends largely on glycolytic pathway for energy metabolism during the intraerythrocytic life stage. Therefore,…”
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Defining the Communication between Agonist and Coactivator Binding in the Retinoid X Receptor α Ligand Binding Domain by Boerma, LeeAnn J., Xia, Gang, Qui, Cheng, Cox, Bryan D., Chalmers, Michael J., Smith, Craig D., Lobo-Ruppert, Susan, Griffin, Patrick R., Muccio, Donald D., Renfrow, Matthew B.

“…Retinoid X receptors (RXRs) are obligate partners for several other nuclear receptors, and they play a key role in several signaling processes. Despite being a…”
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Conformationally Defined Retinoic Acid Analogues. 5. Large-Scale Synthesis and Mammary Cancer Chemopreventive Activity for (2E,4E,6Z,8E)-8- (3‘,4‘-Dihydro-1‘(2‘H)-naphthalen-1‘-ylidene)-3,7-dimethyl-2,4,6-octatrienoic Acid (9cUAB30) by Atigadda, Venkatram R, Vines, Kimberly K, Grubbs, Clinton J, Hill, Donald L, Beenken, Samuel L, Bland, Kirby I, Brouillette, Wayne J, Muccio, Donald D

“…Retinoids that activate the nuclear retinoid X receptors (RXRs) display potential for chemoprevention of breast cancer. We previously reported that 9cUAB30 (1)…”
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Conformationally Defined Retinoic Acid Analogues. 4. Potential New Agents for Acute Promyelocytic and Juvenile Myelomonocytic Leukemias by Muccio, Donald D, Brouillette, Wayne J, Breitman, Theodore R, Taimi, Mohammed, Emanuel, Peter D, Zhang, Xiao-kun, Chen, Guo-quan, Sani, Brahma P, Venepally, Pratap, Reddy, Lakshmi, Alam, Muzaffar, Simpson-Herren, Linda, Hill, Donald L

“…We recently synthesized several conformationally constrained retinoic acid (RA) analogues [8-(2‘-cyclohexen-1‘-ylidene)-3,7-dimethyl-2,4,6-octatrienoic acids…”
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Conformationally Defined Rexinoids and Their Efficacy in the Prevention of Mammary Cancers by Atigadda, Venkatram R., Xia, Gang, Deshpande, Anil, Wu, Lizhi, Kedishvili, Natalia, Smith, Craig D., Krontiras, Helen, Bland, Kirby I., Grubbs, Clinton J., Brouillette, Wayne J., Muccio, Donald D.

“…(2E,4E,6Z,8Z)-8-(3′,4′-Dihydro-1′(2H)-naphthalen-1′-ylidene)-3,7-dimethyl-2,3,6-octatrienoinic acid (UAB30) is currently undergoing clinical evaluation as a…”
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Bioactivity of Peptide Analogs of the Neutrophil Chemoattractant, N-Acetyl-Proline-Glycine-Proline by Haddox, Jeffrey L, Pfister, Roswell R, Muccio, Donald D, Villain, Matteo, Sommers, Charnell I, Chaddha, Manjula, Anantharamaiah, G. M, Brouillette, Wayne J, DeLucas, Lawrence J

“…The release of N-acetyl-proline-glycine-proline (PGP), a chemoattractant resulting from direct alkaline hydrolysis of corneal proteins, is believed to be the…”
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