Rifampicin resistance in mycobacterium tuberculosis patients using GeneXpert at Livingstone Central Hospital for the year 2015: a cross sectional explorative study

Since the recent introduction of GeneXepert for the detection of Tuberculosis (TB) drug resistance mutations in both primary resistance and acquired resistance in Zambia, little has been documented in literature on the issue of rifampicin resistance especially in the face of a high National TB burde...

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Published in:	BMC infectious diseases Vol. 17; no. 1; p. 640
Main Authors:	Masenga, Sepiso K, Mubila, Harrison, Hamooya, Benson M
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 22-09-2017 BioMed Central BMC
Subjects:	Adolescent Adult Aged AIDS-Related Opportunistic Infections - epidemiology Child Child, Preschool Cross-Sectional Studies Drug resistance Drug Resistance, Bacterial - drug effects Drug Resistance, Bacterial - genetics Drug therapy Epidemiology Expected values Female Females GeneXpert HIV Hospitals Human immunodeficiency virus Humans Infant Infectious diseases Internet Laboratories Lung diseases Male Males Microbial drug resistance Middle Aged Mutation Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - genetics Patient outcomes Patients Prevalence Public health Rifampicin resistance Rifampin Rifampin - pharmacology Rifampin - therapeutic use Statistical analysis Statistical methods Statistics Tuberculosis Tuberculosis - drug therapy Tuberculosis - epidemiology Young Adult Zambia - epidemiology West Africa Zambia Mycobacterium tuberculosis Rifampicin resistance GeneXpert
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Summary:	Since the recent introduction of GeneXepert for the detection of Tuberculosis (TB) drug resistance mutations in both primary resistance and acquired resistance in Zambia, little has been documented in literature on the issue of rifampicin resistance especially in the face of a high National TB burden. The study aimed to determine the prevalence of rifampicin resistance in tuberculosis patients at Livingstone Central Hospital for the year 2015. This was a cross sectional study conducted at Livingstone Central Hospital where we reviewed 152 records (from January 1, 2015 to 31st December, 2015) involving patients who presented with clinically suspected TB or documented TB, whose samples were sent to the laboratory for GeneXpert Mycobacterium tuberculosis/rifampicin testing. Statistical evaluations used a one-sample test of proportion and Fisher's exact test. The age of participants ranged from 8 months to 73 years old (median = 34). Of the participants with complete data on gender, 99 (66%) and 52 (34%) were males and females respectively. The TB co-infection with HIV prevalence was 98.3% (p < 0.001). Prevalence of rifampicin resistance was 5.9% and there was no statistical significant difference between being male or female (p = 0.721). We were able to show from our study, evidence of rifampicin resistance at Livingstone Central Hospital. Hence, there was need for further in-depth research and appropriate interventions (i.e close follow-up and patient care for drug resistance positive patients).
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1471-2334 1471-2334
DOI:	10.1186/s12879-017-2750-9