Mycotoxin‐assisted mitochondrial dysfunction and cytotoxicity: Unexploited tools against proliferative disorders

Mycotoxin‐assisted mitochondrial dysfunction and cytotoxicity: Unexploited tools against proliferative disorders

Mitochondria are the powerhouse of cells, which upon dysfunctions may lead to several diseases. Mycotoxins are the toxic secondary metabolites from fungi which are capable of causing diseases and death in humans and animals. They have a versatile mechanism of action in biological systems and can be...

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Published in:IUBMB life Vol. 70; no. 11; pp. 1084 - 1092
Main Authors: Islam, Muhammad Torequl, Mishra, Siddhartha Kumar, Tripathi, Swati, Alencar, Marcus Vinícius Oliveira Barros, e Sousa, João Marcelo de Castro, Rolim, Hercília Maria Lins, de Medeiros, Maria das Graças Freire, Ferreira, Paulo Michel Pinheiro, Rouf, Razina, Uddin, Shaikh Jamal, Mubarak, Mohammad Suleiman, Melo‐Cavalcante, Ana Amélia de Carvalho
Format: Journal Article
Language:English
Published: Hoboken, USA John Wiley & Sons, Inc 01-11-2018
Wiley Subscription Services, Inc
Subjects:
Animals
Apoptosis
biotoxins
Cancer
cancer cells
Cell death
chronic diseases
Citrinin
Cytotoxicity
fungal derived
Fungi
Humans
Metabolites
Mitochondria
Mitochondria - drug effects
Mitochondria - pathology
Mitochondrial DNA
Mycotoxins
Mycotoxins - pharmacology
Neoplasms - drug therapy
Neoplasms - pathology
Oxidative stress
Poisons - pharmacology
Secondary metabolites
biotoxins
fungal derived
cancer cells
chronic diseases
mitochondria
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Summary:Mitochondria are the powerhouse of cells, which upon dysfunctions may lead to several diseases. Mycotoxins are the toxic secondary metabolites from fungi which are capable of causing diseases and death in humans and animals. They have a versatile mechanism of action in biological systems and can be used as lead compounds to treat some diseases including cancer. The present work encompasses analysis on the effects of mycotoxins on mitochondrial dysfunction. Electronic databases such as PubMed, ScienceDirect, Scopus, Web of Science, and Google Scholar were thoroughly searched for up‐to‐date published information associated with those mycotoxins and their effect on mitochondrial dysfunction. Findings suggest that mycotoxins such as citrinin, aflatoxin, and T‐2 toxin exert multi‐edged sword‐like effects in test systems causing mitochondrial dysfunction. Mycotoxins can induce oxidative stress even at low concentration/dose that may be one of the major causes of mitochondrial dysfunction. On the other hand, activation of apoptotic caspases and other proteins by mycotoxins may lead to apoptotic cell death. Thus, mycotoxins‐mediated mitochondrial dysfunction may be related to several chronic diseases which also makes these mycotoxins considerable as lead compounds for inducing toxic effects in cells. Their cytotoxic effects on cancer cells suggest their possible application as chemotherapeutic tools. © 2018 IUBMB Life, 70(11):1084–1092, 2018
ISSN:1521-6543
1521-6551
DOI:10.1002/iub.1932