Search Results - "Mühlradt, Peter F."

Discrimination of bacterial lipoproteins by Toll-like receptor 6 by Takeuchi, Osamu, Kawai, Taro, Mühlradt, Peter F., Morr, Michael, Radolf, Justin D., Zychlinsky, Arturo, Takeda, Kiyoshi, Akira, Shizuo

“…Bacterial lipoproteins (BLP) trigger immune responses via Toll-like receptor 2 (TLR2) and their immunostimulatory properties are attributed to the presence of…”
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Toll-like receptor 2/6 stimulation promotes angiogenesis via GM-CSF as a potential strategy for immune defense and tissue regeneration by Grote, Karsten, Schuett, Harald, Salguero, Gustavo, Grothusen, Christina, Jagielska, Joanna, Drexler, Helmut, Mühlradt, Peter F., Schieffer, Bernhard

“…Toll-like receptors (TLRs) are known primarily as pathogen recognition receptors of the innate immunity, initiating inflammatory pathways to organize the…”
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Cutting Edge: Preferentially the R-Stereoisomer of the Mycoplasmal Lipopeptide Macrophage-Activating Lipopeptide-2 Activates Immune Cells Through a Toll-Like Receptor 2- and MyD88-Dependent Signaling Pathway by Takeuchi, Osamu, Kaufmann, Andreas, Grote, Karsten, Kawai, Taro, Hoshino, Katsuaki, Morr, Michael, Muhlradt, Peter F, Akira, Shizuo

“…Mycoplasmas and their membranes are potent activators of macrophages, the active principle being lipoproteins and lipopeptides. Two stereoisomers of the…”
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Differential recognition of structural details of bacterial lipopeptides by toll-like receptors by Morr, Michael, Takeuchi, Osamu, Akira, Shizuo, Simon, Markus M, Mühlradt, Peter F

“…The question which detailed structures of bacterial modulins determine their relative biological activity and respective host cell receptors was examined with…”
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The TLR-2/TLR-6 agonist macrophage-activating lipopeptide-2 augments human NK cell cytotoxicity when PGE2 production by monocytes is inhibited by a COX-2 blocker by Müller, Christina, Tufa, Dejene M., Chatterjee, Debanjana, Mühlradt, Peter F., Schmidt, Reinhold E., Jacobs, Roland

“…Macrophage-activating lipopeptide-2 (MALP-2) is a potent inducer of proinflammatory cytokine secretion by macrophages, monocytes, and dendritic cells. MALP-2…”
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The Mucosal Adjuvant Macrophage-Activating Lipopeptide-2 Directly Stimulates B Lymphocytes via the TLR2 without the Need of Accessory Cells by Borsutzky, Stefan, Kretschmer, Karsten, Becker, Pablo D, Muhlradt, Peter F, Kirschning, Carsten J, Weiss, Siegfried, Guzman, Carlos A

“…The macrophage-activating lipopeptide-2 (MALP-2) is an agonist of the TLR heterodimer 2/6, which exhibits potent activity as mucosal adjuvant, promoting strong…”
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Pyrexia, anorexia, adipsia, and depressed motor activity in rats during systemic inflammation induced by the Toll-like receptors-2 and -6 agonists MALP-2 and FSL-1 by Hübschle, Thomas, Mütze, Jörg, Mühlradt, Peter F, Korte, Stefan, Gerstberger, Rüdiger, Roth, Joachim

“…Macrophage-activating lipopeptide-2 (MALP-2) from Mycoplasma fermentans has been identified as a pathogen-associated molecular pattern of Mycoplasmas that…”
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The Mycoplasma‐derived lipopeptide MALP‐2 is a potent mucosal adjuvant by Rharbaoui, Faiza, Drabner, Birgit, Borsutzky, Stefan, Winckler, Urte, Morr, Michael, Ensoli, Barbara, Mühlradt, Peter F., Guzmán, Carlos A.

“…The adjuvanticity of MALP‐2, a 2‐kDa synthetic lipopeptide with macrophage‐stimulatory activity, was evaluated in BALB/c mice using β‐galactosidase (β‐gal) as…”
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Intracutaneous injection of the macrophage-activating lipopeptide-2 (MALP-2) which accelerates wound healing in mice - a phase I trial in 12 patients by Niebuhr, Margarete, Mühlradt, Peter F., Wittmann, Miriam, Kapp, Alexander, Werfel, Thomas

“…:  Chronic skin ulcers, such as leg ulcers, pressure sores and diabetic foot ulcers, are a challenge to physicians and medical personnel and a cause of…”
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Toll-Like Receptor 2- and 6-Mediated Stimulation by Macrophage-Activating Lipopeptide 2 Induces Lipopolysaccharide (LPS) Cross Tolerance in Mice, Which Results in Protection from Tumor Necrosis Factor Alpha but in Only Partial Protection from Lethal LPS Doses by DEITERS, Ursula, GUMENSCHEIMER, Marina, GALANOS, Chris, MÜHLRADT, Peter F

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Efficient mucosal delivery of the HIV‐1 Tat protein using the synthetic lipopeptide MALP‐2 as adjuvant by Borsutzky, Stefan, Fiorelli, Valeria, Ebensen, Thomas, Tripiciano, Antonella, Rharbaoui, Faiza, Scoglio, Arianna, Link, Claudia, Nappi, Filomena, Morr, Michael, Buttó, Stefano, Cafaro, Aurelio, Mühlradt, Peter F., Ensoli, Barbara, Guzmán, Carlos A.

“…A major requirement for HIV/AIDS research is the development of a mucosal vaccine that stimulates humoral and cell‐mediated immune responses at systemic and…”
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In Vivo Effects of a Synthetic 2-Kilodalton Macrophage-Activating Lipopeptide of Mycoplasma fermentans after Pulmonary Application by LÜHRMANN, Anke, DEITERS, Ursula, SKOKOWA, Julia, HANKE, Michaela, GESSNER, Johannes E, MÜHLRADT, Peter F, PABST, Reinhard, TSCHERNIG, Thomas

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Structure and Specific Activity of Macrophage-Stimulating Lipopeptides from Mycoplasma hyorhinis by MÜHLRADT, P. F, KIESS, M, MEYER, H, SÜSSMUTH, R, JUNG, G

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Synthetic mycoplasma-derived lipopeptide MALP-2 induces maturation and function of dendritic cells by Weigt, Henning, Mühlradt, Peter F., Emmendörffer, Andreas, Krug, Norbert, Braun, Armin

“…Dendritic cells (DC) modulate immune responses depending on the nature of the antigens. Receptors capable of discriminating these antigens on the basis of the…”
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Mycoplasmal Lipopeptide MALP-2 Induces the Chemoattractant Proteins Macrophage Inflammatory Protein 1α (MIP-1α), Monocyte Chemoattractant Protein 1, and MIP-2 and Promotes Leukocyte Infiltration in Mice by Deiters, U, Muehlradt, P F

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Lipopolysaccharide Stimulates the MyD88-Independent Pathway and Results in Activation of IFN-Regulatory Factor 3 and the Expression of a Subset of Lipopolysaccharide-Inducible Genes by Kawai, Taro, Takeuchi, Osamu, Fujita, Takashi, Inoue, Jun-ichiro, Muhlradt, Peter F, Sato, Shintaro, Hoshino, Katsuaki, Akira, Shizuo

“…Bacterial lipopolysaccharide (LPS) triggers innate immune responses through Toll-like receptor (TLR) 4, a member of the TLR family that participates in…”
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Differential Posttranslational Processing Confers Intraspecies Variation of a Major Surface Lipoprotein and a Macrophage-Activating Lipopeptide of Mycoplasma fermentans by CALCUTT, M. J, KIM, M. F, KARPAS, A. B, MÜHLRADT, P. F, WISE, K. S

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Synergy and Cross-Tolerance Between Toll-Like Receptor (TLR) 2- and TLR4-Mediated Signaling Pathways by Sato, Shintaro, Nomura, Fumiko, Kawai, Taro, Takeuchi, Osamu, Muhlradt, Peter F, Takeda, Kiyoshi, Akira, Shizuo

“…A family of Toll-like receptor (TLR) mediates the cellular response to bacterial cell wall components; murine TLR2 and TLR4 recognize mycoplasmal lipopeptides…”
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Peripheral and central cyclooxygenase (COX) products may contribute to the manifestation of brain-controlled sickness responses during localized inflammation induced by macrophage-activating lipopeptide-2 (MALP-2) by Knorr, Carolin, Marks, Doreen, Gerstberger, Rüdiger, Mühlradt, Peter F., Roth, Joachim, Rummel, Christoph

“…We investigated whether an inflammation-dependent activation of the brain occurs in response to systemic intraperitoneal (i.p.) or local injections of…”
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Isolation, structure elucidation, and synthesis of a macrophage stimulatory lipopeptide from Mycoplasma fermentans acting at picomolar concentration by Mühlradt, P F, Kiess, M, Meyer, H, Süssmuth, R, Jung, G

“…Macrophages are typically stimulated by components of microbial cell walls. Surprisingly, cell wall-less mycoplasmas can also very efficiently stimulate…”
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