Search Results - "Muñoz‐Calleja, Cecilia"

Serum interleukin-8 reflects tumor burden and treatment response across malignancies of multiple tissue origins by Sanmamed, Miguel F, Carranza-Rua, Omar, Alfaro, Carlos, Oñate, Carmen, Martín-Algarra, Salvador, Perez, Guiomar, Landazuri, Sara F, Gonzalez, Alvaro, Gross, Stefanie, Rodriguez, Inmaculada, Muñoz-Calleja, Cecilia, Rodríguez-Ruiz, María, Sangro, Bruno, López-Picazo, José M, Rizzo, Manglio, Mazzolini, Guillermo, Pascual, Juan I, Andueza, Maria Pilar, Perez-Gracia, Jose Luis, Melero, Ignacio

“…Interleukin-8 (IL8) is a chemokine produced by malignant cells of multiple cancer types. It exerts various functions in shaping protumoral vascularization and…”
Get full text

Monoclonal Antibody Therapies for Hematological Malignancies: Not Just Lineage-Specific Targets by Cuesta-Mateos, Carlos, Alcaraz-Serna, Ana, Somovilla-Crespo, Beatriz, Muñoz-Calleja, Cecilia

“…Today, monoclonal antibodies (mAbs) are a widespread and necessary tool for biomedical science. In the hematological cancer field, since rituximab became the…”
Get full text

Deregulated cellular circuits driving immunoglobulins and complement consumption associate with the severity of COVID‐19 patients by Marcos‐Jiménez, Ana, Sánchez‐Alonso, Santiago, Alcaraz‐Serna, Ana, Esparcia, Laura, López‐Sanz, Celia, Sampedro‐Núñez, Miguel, Mateu‐Albero, Tamara, Sánchez‐Cerrillo, Ildefonso, Martínez‐Fleta, Pedro, Gabrie, Ligia, Campo Guerola, Luciana, Rodríguez‐Frade, José Miguel, Casasnovas, José M., Reyburn, Hugh T., Valés‐Gómez, Mar, López‐Trascasa, Margarita, Martín‐Gayo, Enrique, Calzada, María José, Castañeda, Santos, Fuente, Hortensia, González‐Álvaro, Isidoro, Sánchez‐Madrid, Francisco, Muñoz‐Calleja, Cecilia, Alfranca, Arantzazu

“…SARS‐CoV‐2 infection causes an abrupt response by the host immune system, which is largely responsible for the outcome of COVID‐19. We investigated whether the…”
Get full text

Of Lymph Nodes and CLL Cells: Deciphering the Role of CCR7 in the Pathogenesis of CLL and Understanding Its Potential as Therapeutic Target by Cuesta-Mateos, Carlos, Brown, Jennifer R, Terrón, Fernando, Muñoz-Calleja, Cecilia

“…The lymph node (LN) is an essential tissue for achieving effective immune responses but it is also critical in the pathogenesis of chronic lymphocytic leukemia…”
Get full text

Evaluation of the novel therapeutic anti‐CCR7 antibody CAP‐100 as an add‐on therapy in chronic lymphocytic leukemia patients receiving venetoclax by Mateu‐Albero, Tamara, Marcos‐Jimenez, Ana, Delgado‐Wicke, Pablo, Terrón, Fernando, Loscertales, Javier, López‐Matencio, José María Serra, Muñoz‐Calleja, Cecilia, Cuesta‐Mateos, Carlos

“…The Bruton's tyrosine kinase inhibitor ibrutinib and the B‐cell lymphoma 2 anti‐apoptotic protein inhibitor venetoclax provide high response rates in chronic…”
Get full text

NFκB and NLRP3/NLRC4 inflammasomes regulate differentiation, activation and functional properties of monocytes in response to distinct SARS-CoV-2 proteins by Tsukalov, Ilya, Sánchez-Cerrillo, Ildefonso, Rajas, Olga, Avalos, Elena, Iturricastillo, Gorane, Esparcia, Laura, Buzón, María José, Genescà, Meritxell, Scagnetti, Camila, Popova, Olga, Martin-Cófreces, Noa, Calvet-Mirabent, Marta, Marcos-Jimenez, Ana, Martínez-Fleta, Pedro, Delgado-Arévalo, Cristina, de los Santos, Ignacio, Muñoz-Calleja, Cecilia, Calzada, María José, González Álvaro, Isidoro, Palacios-Calvo, José, Alfranca, Arantzazu, Ancochea, Julio, Sánchez-Madrid, Francisco, Martin-Gayo, Enrique

“…Increased recruitment of transitional and non-classical monocytes in the lung during SARS-CoV-2 infection is associated with COVID-19 severity. However,…”
Get full text

A Differential Signature of Circulating miRNAs and Cytokines Between COVID-19 and Community-Acquired Pneumonia Uncovers Novel Physiopathological Mechanisms of COVID-19 by Martínez-Fleta, Pedro, Vera-Tomé, Paula, Jiménez-Fernández, María, Requena, Silvia, Roy-Vallejo, Emilia, Sanz-García, Ancor, Lozano-Prieto, Marta, López-Sanz, Celia, Vara, Alicia, Lancho-Sánchez, Ángel, Martín-Gayo, Enrique, Muñoz-Calleja, Cecilia, Alfranca, Arantzazu, González-Álvaro, Isidoro, Galván-Román, José María, Aspa, Javier, de la Fuente, Hortensia, Sánchez-Madrid, Francisco

“…Coronavirus Disease 2019 (COVID-19) pneumonia is a life-threatening infectious disease, especially for elderly patients with multiple comorbidities. Despite…”
Get full text

Glutathione overproduction mediates lymphoma initiating cells survival and has a sex-dependent effect on lymphomagenesis by H.-Alcántara, Alberto, Kourani, Omar, Marcos-Jiménez, Ana, Martínez-Núñez, Patricia, Herranz-Martín, Estela, Fuentes, Patricia, Toribio, María L., Muñoz-Calleja, Cecilia, Iglesias, Teresa, Campanero, Miguel R.

“…Lymphoid tumor patients often exhibit resistance to standard therapies or experience relapse post-remission. Relapse is driven by Tumor Initiating Cells…”
Get full text

Therapeutic potential of an anti-CCR9 mAb evidenced in xenografts of human CCR9+ tumors by Santamaria, Silvia, Delgado, Marisa, Botas, Marta, Castellano, Eva, Corraliza-Gorjon, Isabel, Lafuente, Paloma, Muñoz-Calleja, Cecilia, Toribio, Maria L., Kremer, Leonor, Garcia-Sanz, Jose A.

“…Relapsed or refractory T acute lymphoblastic leukemia (T-ALL) still carries poor prognosis. Aiming to improve outcomes, the therapeutic potential of an…”
Get full text

PSGL-1, ADAM8, and selectins as potential biomarkers in the diagnostic process of systemic lupus erythematosus and systemic sclerosis: an observational study by San Antonio, Esther, Silván, Javier, Sevilla-Montero, Javier, González-Sánchez, Elena, Muñoz-Callejas, Antonio, Sánchez-Abad, Inés, Ramos-Manzano, Alejandra, Muñoz-Calleja, Cecilia, González-Álvaro, Isidoro, Tomero, Eva G, García-Pérez, Javier, García-Vicuña, Rosario, Vicente-Rabaneda, Esther F, Castañeda, Santos, Urzainqui, Ana

“…Early diagnosis and treatment of Systemic lupus erythematosus (SLE) and Systemic sclerosis (SSc) present significant challenges for clinicians. Although…”
Get full text

Evaluation of Natalizumab Pharmacokinetics and Pharmacodynamics: Toward Individualized Doses by Serra López-Matencio, Jose M., Pérez García, Yaiza, Meca-Lallana, Virginia, Juárez-Sánchez, Raquel, Ursa, Angeles, Vega-Piris, Lorena, Pascual-Salcedo, Dora, de Vries, Annick, Rispens, Theo, Muñoz-Calleja, Cecilia

“…Background: Plasma concentration of natalizumab falls above the therapeutic threshold in many patients who, therefore, receive more natalizumab than necessary…”
Get full text

CD4+ T Cell Immune Specificity Changes After Vaccination in Healthy And COVID-19 Convalescent Subjects by Esparcia-Pinedo, Laura, Martínez-Fleta, Pedro, Ropero, Noelia, Vera-Tomé, Paula, Reyburn, Hugh T, Casasnovas, José M, Rodríguez Frade, José M, Valés-Gómez, Mar, Vilches, Carlos, Martín-Gayo, Enrique, Muñoz-Calleja, Cecilia, Sanchez-Madrid, Francisco, Alfranca, Arantzazu

“…The immune response promoted by SARS-CoV-2 vaccination is relevant to develop novel vaccines and optimized prevention strategies. We analyzed the adaptive…”
Get full text

Targeting cancer homing into the lymph node with a novel anti-CCR7 therapeutic antibody: the paradigm of CLL by Cuesta-Mateos, Carlos, Juárez-Sánchez, Raquel, Mateu-Albero, Tamara, Loscertales, Javier, Mol, Wim, Terrón, Fernando, Muñoz-Calleja, Cecilia

“…Lymph node (LN) is a key tissue in the pathophysiology of mature blood cancers, especially for chronic lymphocytic leukemia (CLL). Within the multiple…”
Get full text

Simultaneous Determination of Imatinib, Dasatinib, and Nilotinib by Liquid Chromatography-Tandem Mass Spectrometry and Its Application to Therapeutic Drug Monitoring by Wojnicz, Aneta, Colom-Fernández, Beatriz, Steegmann, Juan L, Muñoz-Calleja, Cecilia, Abad-Santos, Francisco, Ruiz-Nuño, Ana

“…Imatinib, dasatinib, and nilotinib are tyrosine kinase inhibitors (TKIs) used as first-line treatment of chronic myeloid leukemia. Therapeutic drug monitoring…”
Get full text

CD13 as a new tumor target for antibody-drug conjugates: validation with the conjugate MI130110 by Domínguez, Juan Manuel, Pérez-Chacón, Gema, Guillén, María José, Muñoz-Alonso, María José, Somovilla-Crespo, Beatriz, Cibrián, Danay, Acosta-Iborra, Bárbara, Adrados, Magdalena, Muñoz-Calleja, Cecilia, Cuevas, Carmen, Sánchez-Madrid, Francisco, Avilés, Pablo, Zapata, Juan M

“…In the search for novel antibody-drug conjugates (ADCs) with therapeutic potential, it is imperative to identify novel targets to direct the antibody moiety…”
Get full text

Immediate Effects of Dasatinib on the Migration and Redistribution of Naïve and Memory Lymphocytes Associated With Lymphocytosis in Chronic Myeloid Leukemia Patients by Colom-Fernández, Beatriz, Kreutzman, Anna, Marcos-Jiménez, Ana, García-Gutiérrez, Valentín, Cuesta-Mateos, Carlos, Portero-Sainz, Itxaso, Pérez-García, Yaiza, Casado, Luis Felipe, Sánchez-Guijo, Fermín, Martínez-López, Joaquín, Ayala, Rosa M, Boqué, Concha, Xicoy, Blanca, Montero, Isabel, Soto, César, Paz, Raquel, Silva, Gabriela, Vega-Piris, Lorena, Steegmann, Juan Luis, Muñoz-Calleja, Cecilia

“…Dasatinib is a dual SRC/ABL tyrosine kinase inhibitor used to treat chronic myeloid leukemia (CML) that is known to have unique immunomodulatory effects. In…”
Get full text

Erythroid SLC7A5/SLC3A2 amino acid carrier controls red blood cell size and maturation by Bouthelier, Antonio, Fernández-Arroyo, Lucía, Mesa-Ciller, Claudia, Cibrian, Danay, Martín-Cófreces, Noa Beatriz, Castillo-González, Raquel, Calero, Macarena, Herráez-Aguilar, Diego, Guajardo-Grence, Andrea, Pacheco, Ana María, Marcos-Jiménez, Ana, Quiroga, Borja, Morado, Marta, Monroy, Francisco, Muñoz-Calleja, Cecilia, Sánchez-Madrid, Francisco, Urrutia, Andrés A., Aragonés, Julián

“…Inhibition of the heterodimeric amino acid carrier SLC7A5/SLC3A2 (LAT1/CD98) has been widely studied in tumor biology but its role in physiological conditions…”
Get full text

Anti-CCR7 therapy exerts a potent anti-tumor activity in a xenograft model of human mantle cell lymphoma by Somovilla-Crespo, Beatriz, Alfonso-Pérez, Manuel, Cuesta-Mateos, Carlos, Carballo-de Dios, Cristina, Beltrán, Amada E, Terrón, Fernando, Pérez-Villar, Juan J, Gamallo-Amat, Carlos, Pérez-Chacón, Gema, Fernández-Ruiz, Elena, Zapata, Juan M, Muñoz-Calleja, Cecilia

“…The chemokine receptor CCR7 mediates lymphoid dissemination of many cancers, including lymphomas and epithelial carcinomas, thus representing an attractive…”
Get full text

COVID-19 severity associates with pulmonary redistribution of CD1c+ DCs and inflammatory transitional and nonclassical monocytes by Sánchez-Cerrillo, Ildefonso, Landete, Pedro, Aldave, Beatriz, Sánchez-Alonso, Santiago, Sánchez-Azofra, Ana, Marcos-Jiménez, Ana, Ávalos, Elena, Alcaraz-Serna, Ana, de Los Santos, Ignacio, Mateu-Albero, Tamara, Esparcia, Laura, López-Sanz, Celia, Martínez-Fleta, Pedro, Gabrie, Ligia, Del Campo Guerola, Luciana, de la Fuente, Hortensia, Calzada, María J, González-Álvaro, Isidoro, Alfranca, Arantzazu, Sánchez-Madrid, Francisco, Muñoz-Calleja, Cecilia, Soriano, Joan B, Ancochea, Julio, Martín-Gayo, Enrique

“…SARS-CoV-2 is responsible for the development of coronavirus disease 2019 (COVID-19) in infected individuals, who can either exhibit mild symptoms or progress…”
Get full text

Effect of ibrutinib on CCR7 expression and functionality in chronic lymphocytic leukemia and its implication for the activity of CAP-100, a novel therapeutic anti-CCR7 antibody by Mateu-Albero, Tamara, Juárez-Sánchez, Raquel, Loscertales, Javier, Mol, Wim, Terrón, Fernando, Muñoz-Calleja, Cecilia, Cuesta-Mateos, Carlos

“…CAP-100 is a novel therapeutic antibody directed against the ligand binding site of human CCR7. This chemokine receptor is overexpressed in chronic lymphocytic…”
Get full text