The endotoxin binding and antioxidative properties of ceramic granules

Objective: To investigate the possible antimicrobial activities and the detoxification (endotoxin binding and free radical scavenging) properties of Cerdak. Method: In order to measure the antimicrobial activity of Cerdak, microorganisms were separately inoculated into nutrient agar in the presence...

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Bibliographic Details
Published in:	Journal of wound care Vol. 16; no. 6; pp. 271 - 274
Main Authors:	Opoku, A.R, Sithole, S.S, Mthimkhulu, N.P, Nel, W
Format:	Journal Article
Language:	English
Published:	London MA Healthcare 01-06-2007
Subjects:	Antioxidants - metabolism Antioxidants - pharmacology Bandages Biocompatible Materials - chemistry Biocompatible Materials - metabolism Biphenyl Compounds - chemistry Calcium Phosphates - chemistry Calcium Phosphates - metabolism Ceramics - chemistry Ceramics - metabolism DNA Damage - drug effects Endotoxins - metabolism Enterobacteriaceae - drug effects Enterobacteriaceae - metabolism Free Radical Scavengers - metabolism Free Radical Scavengers - pharmacology Hydrazines - chemistry Hydrogen Peroxide - pharmacology Nursing Oxidation-Reduction - drug effects Picrates Plasmids - drug effects Plasmids - genetics Plasmids - radiation effects Protein Binding absorption Cerdak endotoxin binding free radical scavenging
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Summary:	Objective: To investigate the possible antimicrobial activities and the detoxification (endotoxin binding and free radical scavenging) properties of Cerdak. Method: In order to measure the antimicrobial activity of Cerdak, microorganisms were separately inoculated into nutrient agar in the presence of Cerdak, and growth was observed over 48 hours. Cerdak was incubated with 4000EU/ml endotoxin, and the residual endotoxin was determined over 24 hours. The decrease in the colour of ABTS and DPPH (inorganic free radicals) in the presence of Cerdak was colourimetrically monitored as a measure of Cerdax’s free radical scavenging ability. DNA was exposed to hydrogen peroxide and ultraviolet irradiation in the presence and absence of Cerdak. The DNA strand break was then observed through electrophoresis. Results: While Cerdak had little or no antibacterial activities, it demonstrated a high water and endotoxin-binding capacity. It also protected DNA from damage by reactive oxygen species. Conclusion: The detoxification properties of Cerdak could contribute to its healing abilities. Declaration of interest: None.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	0969-0700 2052-2916
DOI:	10.12968/jowc.2007.16.6.27068