Bovine papilloma: aetiology, pathology, immunology, disease status, diagnosis, control, prevention and treatment: a review

Bovine papilloma: aetiology, pathology, immunology, disease status, diagnosis, control, prevention and treatment: a review

Bovine papillomavirus (BPV) induces diseases of economic and veterinary importance leading to significant economic losses to livestock owners such as leather depreciation and mortality when it progresses to neoplasms. BPV affects the spinosum and granulosum layers of the skin causing warts. There ar...

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Bibliographic Details
Published in:Comparative clinical pathology Vol. 28; no. 3; pp. 737 - 745
Main Authors: Ugochukwu, Iniobong Chukwuebuka Ikenna, Aneke, Chioma Inyang, Idoko, Idoko Sunday, Sani, Nuhu Abdulazeez, Amoche, Adole Jolly, Mshiela, Wayuta Philip, Ede, Richard Emmanuel, Ibrahim, Najume Dogowar Giginya, Njoku, Celestine Ibe O., Sackey, Anthony Kojo Beku
Format: Journal Article
Language:English
Published: London Springer London 01-06-2019
Springer Nature B.V
Subjects:
Diagnosis
Domestic animals
Gastrointestinal tract
Hematology
Hematuria
Immunohistochemistry
Immunology
Leather
Livestock
Malignancy
Medical diagnosis
Medicine
Medicine & Public Health
Oncology
Papilloma
Pathogenicity
Pathology
Polymerase chain reaction
Review Article
Skin
Tumors
Urinary bladder
Warts
Bovine papillomavirus
Mastitis
Papillomatosis
Neoplasia
Sarcoids
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Summary:Bovine papillomavirus (BPV) induces diseases of economic and veterinary importance leading to significant economic losses to livestock owners such as leather depreciation and mortality when it progresses to neoplasms. BPV affects the spinosum and granulosum layers of the skin causing warts. There are many reportage of BPV infection in domestic animals such as cattle, birds and wild animals such as tapir, giraffe, antelope and zebras. It also causes equine sarcoids in horses and donkeys. Gross lesions seen are mainly benign papillomas which most times regress but occasionally persist and progress to malignancy of the urinary bladder and upper alimentary tract leading to Enzootic haematuria. Equine sarcoids could be of the occult, nodular or verrucous types. Due to the ability to BPV to cause cancers, haematuria and skin pathologies, diagnosis of this infection has attracted huge interests. Diagnostic techniques include clinical examination, histopathology, polymerase chain reaction (PCR) Southern blot, dot blot, reverse blot, in situ hybridization and immunohistochemistry. All the aforementioned have been very helpful in the diagnosis of BPV. In conclusion, this review focused on the aetiology, viral structure pathogenicity, transmission, macroscopic and microscopic pathology, pathogenesis, immunology, gene products, prevention, treatment and control of this virus in affected animal species.
ISSN:1618-5641
1618-565X
DOI:10.1007/s00580-018-2785-3