Search Results - "Msengi, Eliwaza Naomi"
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Whole Body Ip6k1 Deletion Protects Mice from Age-Induced Weight Gain, Insulin Resistance and Metabolic Dysfunction
Published in International journal of molecular sciences (12-02-2022)“…(1) Background: We previously demonstrated that disruption of IP6K1 improves metabolism, protecting mice from high-fat diet-induced obesity, insulin…”
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Journal Article -
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Pleiotropic actions of IP6K1 mediate hepatic metabolic dysfunction to promote nonalcoholic fatty liver disease and steatohepatitis
Published in Molecular metabolism (Germany) (01-12-2021)“…Obesity and insulin resistance greatly increase the risk of nonalcoholic fatty liver disease and steatohepatitis (NAFLD/NASH). We have previously discovered…”
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Journal Article -
3
Defining the Mechanistic Role of the U-Box E3 Ubiquitin Ligase Ube4A in Metabolic Health and Diseases
Published 01-01-2023“…Obesity is a rising global health issue. Moreover, obesity and obesity-induced insulin resistance increase the risk of development and progression of other…”
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Dissertation -
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SR-135, a peroxynitrite decomposing catalyst, enhances β-cell function and survival in B6D2F1 mice fed a high fat diet
Published in Archives of biochemistry and biophysics (01-07-2015)“…•A peroxynitrite decomposing catalyst, SR-135, is readily taken up into β-cells.•SR-135 treatment enhanced β-cell function and survival under nutrient…”
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Journal Article -
5
Design and Synthesis of Functionalized Mn(III) Dipyrromethene Complexes as Peroxynitrite Decomposition Catalysts
Published 01-01-2014“…The excessive production of peroxynitrite (ONOO- ) anion is well-known to play a significant role in numerous diseases including chronic inflammation, Type II…”
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Dissertation