Search Results - "Mrosek, Michael"

Flt3 is a target of coumestrol in protecting against UVB-induced skin photoaging by Park, Gaeun, Baek, Sohee, Kim, Jong-Eun, Lim, Tae-gyu, Lee, Charles C., Yang, Hee, Kang, Young-Gyu, Park, Jun Seong, Augustin, Martin, Mrosek, Michael, Lee, Chang Yong, Dong, Zigang, Huber, Robert, Lee, Ki Won

“…[Display omitted] While skin aging is a naturally occurring process by senescence, exposure to ultraviolet (UV) radiation accelerates wrinkle formation and…”
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Molecular determinants for the recruitment of the ubiquitin-ligase MuRF-1 onto M-line titin by Mrosek, Michael, Labeit, Dietmar, Witt, Stephanie, Heerklotz, Heiko, von Castelmur, Eleonore, Labeit, Siegfried, Mayans, Olga

“…Titin forms an intrasarcomeric filament system in vertebrate striated muscle, which has elastic and signaling properties and is thereby central to…”
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Non-attended data acquisition in the protein laboratory using the SCOUT sample changer by Mrosek, Michael

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Structural Analysis of B-Box 2 from MuRF1: Identification of a Novel Self-Association Pattern in a RING-like Fold by Mrosek, Michael, Meier, Sebastian, Ucurum-Fotiadis, Zöhre, von Castelmur, Eleonore, Hedbom, Erik, Lustig, Ariel, Grzesiek, Stephan, Labeit, Dietmar, Labeit, Siegfried, Mayans, Olga

“…The B-box motif is the defining feature of the TRIM family of proteins, characterized by a RING finger−B-box−coiled coil tripartite fold. We have elucidated…”
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A common antigenic motif recognized by naturally occurring human VH5–51/VL4–1 anti-tau antibodies with distinct functionalities by Apetri, Adrian, Crespo, Rosa, Juraszek, Jarek, Pascual, Gabriel, Janson, Roosmarijn, Zhu, Xueyong, Zhang, Heng, Keogh, Elissa, Holland, Trevin, Wadia, Jay, Verveen, Hanneke, Siregar, Berdien, Mrosek, Michael, Taggenbrock, Renske, Ameijde, Jeroenvan, Inganäs, Hanna, van Winsen, Margot, Koldijk, Martin H., Zuijdgeest, David, Borgers, Marianne, Dockx, Koen, Stoop, Esther J. M., Yu, Wenli, Brinkman-van der Linden, Els C., Ummenthum, Kimberley, van Kolen, Kristof, Mercken, Marc, Steinbacher, Stefan, de Marco, Donata, Hoozemans, Jeroen J., Wilson, Ian A., Koudstaal, Wouter, Goudsmit, Jaap

“…Misfolding and aggregation of tau protein are closely associated with the onset and progression of Alzheimer’s Disease (AD). By interrogating IgG+ memory B…”
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Next-generation home-lab systems for the changing structural biology landscape by Benning, Matthew M., Mrosek, Michael

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Performance without the pain, extending the capabilities of low-maintenance home-lab systems for biological crystallography by Benning, Matthew M., Mrosek, Michael

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A reliable and versatile tool for high-end in-house structural studies by Mrosek, Michael, Smith, Vernon, Adam, Martin

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A photon-counting large-area detector – PHOTON III by Mrosek, Michael, Adam, Martin, Becker, Bruce, Durst, Roger, Kaercher, Joerg

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Design and Synthesis of Novel Lactate Dehydrogenase A Inhibitors by Fragment-Based Lead Generation by Ward, Richard A, Brassington, Claire, Breeze, Alexander L, Caputo, Alessandro, Critchlow, Susan, Davies, Gareth, Goodwin, Louise, Hassall, Giles, Greenwood, Ryan, Holdgate, Geoffrey A, Mrosek, Michael, Norman, Richard A, Pearson, Stuart, Tart, Jonathan, Tucker, Julie A, Vogtherr, Martin, Whittaker, David, Wingfield, Jonathan, Winter, Jon, Hudson, Kevin

“…Lactate dehydrogenase A (LDHA) catalyzes the conversion of pyruvate to lactate, utilizing NADH as a cofactor. It has been identified as a potential therapeutic…”
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β‑Glucocerebrosidase Modulators Promote Dimerization of β‑Glucocerebrosidase and Reveal an Allosteric Binding Site by Zheng, Jianbin, Chen, Long, Skinner, Owen S, Ysselstein, Daniel, Remis, Jonathan, Lansbury, Peter, Skerlj, Renato, Mrosek, Michael, Heunisch, Ursula, Krapp, Stephan, Charrow, Joel, Schwake, Michael, Kelleher, Neil L, Silverman, Richard B, Krainc, Dimitri

“…β-Glucocerebrosidase (GCase) mutations cause Gaucher’s disease and are a high risk factor in Parkinson’s disease. The implementation of a small molecule…”
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Novel irreversible covalent BTK inhibitors discovered using DNA-encoded chemistry by Guilinger, John P., Archna, Archna, Augustin, Martin, Bergmann, Andreas, Centrella, Paolo A., Clark, Matthew A., Cuozzo, John W., Däther, Maike, Guié, Marie-Aude, Habeshian, Sevan, Kiefersauer, Reiner, Krapp, Stephan, Lammens, Alfred, Lercher, Lukas, Liu, Julie, Liu, Yanbin, Maskos, Klaus, Mrosek, Michael, Pflügler, Klaus, Siegert, Markus, Thomson, Heather A., Tian, Xia, Zhang, Ying, Konz Makino, Debora L., Keefe, Anthony D.

“…[Display omitted] Libraries of DNA-Encoded small molecules created using combinatorial chemistry and synthetic oligonucleotides are being applied to drug…”
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Fragment Screening by Weak Affinity Chromatography: Comparison with Established Techniques for Screening against HSP90 by Meiby, Elinor, Simmonite, Heather, le Strat, Loic, Davis, Ben, Matassova, Natalia, Moore, Jonathan D, Mrosek, Michael, Murray, James, Hubbard, Roderick E, Ohlson, Sten

“…The increasing use of fragment-based lead discovery (FBLD) in industry as well as in academia creates a high demand for sensitive and reliable methods to…”
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Highest data quality with latest in-house sources and detector technology by Ott, Holger, Stuerzer, Tobias, Mrosek, Michael, Ruf, Michael, Noll, Bruce C., Benning, Matthew, Adam, Martin, Graf, Juergen

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Shine bright like a diamond: microfocus X-ray sealed-tube sources with diamond hybrid anode technology by Graf, Juergen, Stuerzer, Tobias, Ott, Holger, Mrosek, Michael, Benning, Matt, Noll, Bruce, Durst, Roger, Radcliffe, Paul, Michaelsen, Carsten

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A common antigenic motif recognized by naturally occurring human V H 5-51/V L 4-1 anti-tau antibodies with distinct functionalities by Apetri, Adrian, Crespo, Rosa, Juraszek, Jarek, Pascual, Gabriel, Janson, Roosmarijn, Zhu, Xueyong, Zhang, Heng, Keogh, Elissa, Holland, Trevin, Wadia, Jay, Verveen, Hanneke, Siregar, Berdien, Mrosek, Michael, Taggenbrock, Renske, Ameijde, Jeroenvan, Inganäs, Hanna, van Winsen, Margot, Koldijk, Martin H, Zuijdgeest, David, Borgers, Marianne, Dockx, Koen, Stoop, Esther J M, Yu, Wenli, Brinkman-van der Linden, Els C, Ummenthum, Kimberley, van Kolen, Kristof, Mercken, Marc, Steinbacher, Stefan, de Marco, Donata, Hoozemans, Jeroen J, Wilson, Ian A, Koudstaal, Wouter, Goudsmit, Jaap

“…Misfolding and aggregation of tau protein are closely associated with the onset and progression of Alzheimer's Disease (AD). By interrogating IgG memory B…”
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Development and testing of a criteria and indicators system for sustainable forest management at the local level. Case study at the Haliburton Forest and Wild Life Reserve Ltd., Canada by Mrosek, Thorsten Michael

“…The concept of criteria and indicators (C&I) for sustainable forest management (SFM) requires further development and testing at the local level. Suitable case…”
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Development and testing of a criteria and indicators system for sustainable forest management at the local level. Case study at the Haliburton Forest and Wild Life Reserve Ltd., Canada by Mrosek, Thorsten Michael

“…The concept of criteria and indicators (C&I) for sustainable forest management (SFM) requires further development and testing at the local level. Suitable case…”
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