Search Results - "Mridha, Auvro R"

TLR9 is up-regulated in human and murine NASH: pivotal role in inflammatory recruitment and cell survival by Mridha, Auvro R, Haczeyni, Fahrettin, Yeh, Matthew M, Haigh, W Geoffrey, Ioannou, George N, Barn, Vanessa, Ajamieh, Hussam, Adams, Leon, Hamdorf, Jeffrey M, Teoh, Narci C, Farrell, Geoffrey C

“…Background and aims TLR9 deletion protects against steatohepatitis due to choline-amino acid depletion and high-fat diet. We measured in human non-alcoholic…”
Get more information

Strain dependence of diet-induced NASH and liver fibrosis in obese mice is linked to diabetes and inflammatory phenotype by Farrell, Geoffrey C., Mridha, Auvro R., Yeh, Matthew M., Arsov, Todor, Van Rooyen, Derrick M., Brooling, John, Nguyen, Tori, Heydet, Deborah, Delghingaro-Augusto, Viviane, Nolan, Christopher J., Shackel, Nicholas A., McLennan, Susan V., Teoh, Narci C., Larter, Claire Z.

“…Background & Aims Obese Alms1 mutant (foz/foz) NOD.B10 mice develop diabetes and fibrotic NASH when fed high‐fat(HF) diet. To establish whether diabetes or…”
Get full text

The selective peroxisome proliferator–activated receptor‐delta agonist seladelpar reverses nonalcoholic steatohepatitis pathology by abrogating lipotoxicity in diabetic obese mice by Haczeyni, Fahrettin, Wang, Hans, Barn, Vanessa, Mridha, Auvro R., Yeh, Matthew M., Haigh, W. Geoffrey, Ioannou, George N., Choi, Yun‐Jung, McWherter, Charles A., Teoh, Narcissus C.‐H., Farrell, Geoffrey C.

“…Lipotoxicity associated with insulin resistance is central to nonalcoholic steatohepatitis (NASH) pathogenesis. To date, only weight loss fully reverses NASH…”
Get full text

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice by Mridha, Auvro R, Wree, Alexander, Robertson, Avril A.B, Yeh, Matthew M, Johnson, Casey D, Van Rooyen, Derrick M, Haczeyni, Fahrettin, Teoh, Narci C.-H, Savard, Christopher, Ioannou, George N, Masters, Seth L, Schroder, Kate, Cooper, Matthew A, Feldstein, Ariel E, Farrell, Geoffrey C

“…Graphical abstract…”
Get full text

Encapsulation and Transplantation of Pancreatic Progenitor Cells by Carroll, Luke, Mridha, Auvro R, Tuch, Bernard E

“…Type 1 diabetes, characterized by autoimmune destruction of pancreatic beta cells, affects 41 million people worldwide. Beta cell replacement therapies have…”
Get more information

Obeticholic acid improves adipose morphometry and inflammation and reduces steatosis in dietary but not metabolic obesity in mice by Haczeyni, Fahrettin, Poekes, Laurence, Wang, Hans, Mridha, Auvro R., Barn, Vanessa, Geoffrey Haigh, W., Ioannou, George N., Yeh, Matthew M., Leclercq, Isabelle A., Teoh, Narcissus C., Farrell, Geoffrey C.

“…Objective Nonalcoholic steatohepatitis (NASH) is the outcome of interactions between overnutrition, energy metabolism, and adipose function. Obeticholic acid…”
Get full text

Exercise improves adipose function and inflammation and ameliorates fatty liver disease in obese diabetic mice by Haczeyni, Fahrettin, Barn, Vanessa, Mridha, Auvro R., Yeh, Matthew M., Estevez, Emma, Febbraio, Mark A., Nolan, Christopher J., Bell‐Anderson, Kim S., Teoh, Narci C., Farrell, Geoffrey C.

“…Objective Adipose inflammation and dysfunction underlie metabolic obesity. Exercise improves glycemic control and metabolic indices, but effects on adipose…”
Get full text