Search Results - "Mrema, Ibrahim"

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    Quinone bioreductive prodrugs as delivery agents by Jaffar, Mohammed, Abou-Zeid, Nathalie, Bai, Li, Mrema, Ibrahim, Robinson, Ian, Tanner, Richard, Stratford, Ian J

    Published in Current drug delivery (01-10-2004)
    “…Quinone bioreductive prodrugs were developed to target the hypoxic or the reductase- rich population of solid tumours. The mechanism of their selective…”
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    Journal Article
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    3-Substituted-5-aziridinyl-1-methylindole-4,7-diones as NQO1-directed antitumour agents: mechanism of activation and cytotoxicity in vitro by Jaffar, Mohammed, Phillips, Roger M, Williams, Kaye J, Mrema, Ibrahim, Cole, Christian, Wind, Natasha S, Ward, Timothy H, Stratford, Ian J, Patterson, Adam V

    Published in Biochemical pharmacology (01-10-2003)
    “…Indolequinone agents are a unique class of bioreductive cytotoxins that can function as dual substrates for both one- and two-electron reductases. This endows…”
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    Journal Article