Search Results - "Mrema, Ibrahim"
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Design, synthesis, molecular modeling, and biological evaluation of sulfanilamide-imines derivatives as potential anticancer agents
Published in Naunyn-Schmiedeberg's archives of pharmacology (01-09-2013)“…A series of sulfanilamide Schiff base derivatives (1 to 15) have been designed as potential antitubulin agents depending on the chemical structures of…”
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Design, Synthesis and Biological Evaluation of Some Triazole Schiff's Base Derivatives as Potential Antitubercular Agents
Published in The open medicinal chemistry journal (2018)“…Tuberculosis (TB) is the second important cause of death worldwide caused by a bacterium called . There is a need to find and develop new Anti-TB medications…”
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Quinone bioreductive prodrugs as delivery agents
Published in Current drug delivery (01-10-2004)“…Quinone bioreductive prodrugs were developed to target the hypoxic or the reductase- rich population of solid tumours. The mechanism of their selective…”
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3-Substituted-5-aziridinyl-1-methylindole-4,7-diones as NQO1-directed antitumour agents: mechanism of activation and cytotoxicity in vitro
Published in Biochemical pharmacology (01-10-2003)“…Indolequinone agents are a unique class of bioreductive cytotoxins that can function as dual substrates for both one- and two-electron reductases. This endows…”
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