Translocation t(X;10)(p10;p10): a rare chromosomal abnormality in a new born female with acute myeloid leukemia

Sex chromosomes are infrequently involved in patients with hematologic malignancies. In most instances, the abnormality is either duplication in the q arm or deletion and translocation involving the q13 and q24 regions. We report herein a rare translocation t(X;10)(p10;p10) in a newborn with 2 month...

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Bibliographic Details
Published in:	Medical oncology (Northwood, London, England) Vol. 29; no. 2; pp. 1134 - 1136
Main Authors:	Bennour, Ayda, Sennana, Halima, Zaier, Monia, Ouahchi, Ines, Mrad, Zannouba, Ben Youssef, Yosra, Khelif, Abderrahim, Saad, Ali
Format:	Journal Article
Language:	English
Published:	Boston Springer US 01-06-2012 Springer Nature B.V
Subjects:	Acute myeloid leukemia Case Report Chemotherapy Chromosome Aberrations Chromosome translocations Chromosomes, Human, Pair 10 - genetics Chromosomes, Human, X - genetics Fab Female Fluorescence in situ hybridization Hematology Humans In Situ Hybridization, Fluorescence Infant Internal Medicine Karyotyping Leukemia Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - therapy Malignancy Medicine Medicine & Public Health Neonates Oncology Pathology Prognosis Remission Sex chromosomes Translocation, Genetic - genetics X chromosome Sex chromosome abnormality Whole chromosome painting t(X;10)(p10;p10) Neonatal AML 4 Acute myeloid leukemia Fluorescence in situ hybridization
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Summary:	Sex chromosomes are infrequently involved in patients with hematologic malignancies. In most instances, the abnormality is either duplication in the q arm or deletion and translocation involving the q13 and q24 regions. We report herein a rare translocation t(X;10)(p10;p10) in a newborn with 2 months and 20 days with acute myeloid leukemia (AML) (FAB, M4). Cytogenetic analysis detected a cell clone with t(X;10)(p10;p10). Thus was confirmed by FISH analysis with whole chromosome painting (WCP) specific for chromosomes X and 10. The patient was treated with chemotherapy, and a complete morphologic and cytogenetic remission was achieved. To our knowledge, our case is the first report of a neonatal AML4 with t(X; 10). The patient had an excellent early response to a salvage AML-type therapy. The prognostic significance of the t(X; 10) in this setting remains unclear. Due to the rarity of this translocation, further cytogenetic and molecular biologic studies are required to elucidate the clinical and molecular significance of this unusual karyotypic finding.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	1357-0560 1559-131X
DOI:	10.1007/s12032-011-9908-x