Cytogenetic study in cultured human lymphocytes treated with three commonly used preservatives

Potassium sorbate, sodium benzoate and potassium nitrate have been tested for their genotoxic, cytostatic and cytotoxic potential in human peripheral blood cells in vitro. Potassium nitrate has shown no activity in the test system. When potassium sorbate and sodium benzoate were used at concentratio...

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Bibliographic Details
Published in:	Food and chemical toxicology Vol. 46; no. 7; pp. 2390 - 2393
Main Authors:	Mpountoukas, P., Vantarakis, A., Sivridis, E., Lialiaris, T.
Format:	Journal Article
Language:	English
Published:	Oxford Elsevier Ltd 01-07-2008 New York, NY Elsevier Science
Subjects:	Biological and medical sciences cell culture Cell Cycle - drug effects cell growth cell proliferation Cells, Cultured chemical concentration Chromosome Aberrations - chemically induced cytostatic properties Cytostaticity Cytotoxicity dose response Dose-Response Relationship, Drug food additives food preservatives Food Preservatives - toxicity Genotoxicity Humans lymphocytes Lymphocytes - drug effects Medical sciences Mutagenicity Tests Nitrates - toxicity Potassium Compounds - toxicity Potassium nitrate Potassium sorbate Sister chromatid exchanges (SCEs) Sodium benzoate Sodium Benzoate - toxicity Sorbic Acid - toxicity Toxicology Potassium nitrate Sodium benzoate Sister chromatid exchanges (SCEs) Genotoxicity Cytotoxicity Cytostaticity Potassium sorbate Human Cell culture Treatment Preservative Potassium ion Sister chromatid exchange Potassium sorbate;Sodium benzoate;Potassium nitrate;Sister chromatid exchanges (SCEs);Genotoxicity;Cytostaticity;Cytotoxicity Cytogenetics Inorganic element In vitro Lymphocyte Potassium
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Summary:	Potassium sorbate, sodium benzoate and potassium nitrate have been tested for their genotoxic, cytostatic and cytotoxic potential in human peripheral blood cells in vitro. Potassium nitrate has shown no activity in the test system. When potassium sorbate and sodium benzoate were used at concentrations of 2.0, 0.2 and 0.02 mM no cytostatic activity was detected. However, concentrations of 4 and 8 mM have shown a weak cytostaticity. Additionally, a genotoxic activity using the SCE methodology has been observed at 8 mM of sodium benzoate and at 4 and 8 mM of potassium sorbate. No cytotoxic activity has been induced by the three preservatives. Data demonstrate that the preservatives at low concentrations can be considered as non genotoxic under conditions tested.
Bibliography:	http://dx.doi.org/10.1016/j.fct.2008.03.021
ISSN:	0278-6915 1873-6351
DOI:	10.1016/j.fct.2008.03.021