Measurement of Liver Iron Concentration by MRI Is Reproducible

Purpose. The objectives were (i) construction of a phantom to reproduce the behavior of iron overload in the liver by MRI and (ii) assessment of the variability of a previously validated method to quantify liver iron concentration between different MRI devices using the phantom and patients. Materia...

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Bibliographic Details
Published in:	BioMed research international Vol. 2015; no. 2015; pp. 1 - 8
Main Authors:	Asensio, Ana Belén, Banales, Jesús, Moyua, Aranzazu, Arozena, Xabier, Zarco, Miguel, Jauregui, Lourdes, Vicente, Ohiana, Garcia, Nerea, San Vicente, Manuel, Aldazábal, Pablo, Garrido, Adolfo, Casado, Alfonso, Castiella, Agustín, Emparanza, José I., Alústiza, José María, Salvador, Emma
Format:	Journal Article
Language:	English
Published:	Cairo, Egypt Hindawi Publishing Corporation 01-01-2015 John Wiley & Sons, Inc Hindawi Limited
Subjects:	Assessments Biopsy Clinical medicine Devices Humans Iron Iron - metabolism Iron and steel industry Iron in the body Liver Liver - diagnostic imaging Liver - metabolism Magnetic resonance imaging Magnetic Resonance Imaging - instrumentation Magnetic Resonance Imaging - methods Mathematical models Measurement Medical research Metabolism Methods Muscles NMR Nuclear magnetic resonance Older people Patients Phantoms, Imaging Physiological aspects Radiography Ratios Reproducibility of Results
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Summary:	Purpose. The objectives were (i) construction of a phantom to reproduce the behavior of iron overload in the liver by MRI and (ii) assessment of the variability of a previously validated method to quantify liver iron concentration between different MRI devices using the phantom and patients. Materials and Methods. A phantom reproducing the liver/muscle ratios of two patients with intermediate and high iron overload. Nine patients with different levels of iron overload were studied in 4 multivendor devices and 8 of them were studied twice in the machine where the model was developed. The phantom was analysed in the same equipment and 14 times in the reference machine. Results. FeCl3 solutions containing 0.3, 0.5, 0.6, and 1.2 mg Fe/mL were chosen to generate the phantom. The average of the intramachine variability for patients was 10% and for the intermachines 8%. For the phantom the intramachine coefficient of variation was always below 0.1 and the average of intermachine variability was 10% for moderate and 5% for high iron overload. Conclusion. The phantom reproduces the behavior of patients with moderate or high iron overload. The proposed method of calculating liver iron concentration is reproducible in several different 1.5 T systems.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Academic Editor: Pascal Niggemann
ISSN:	2314-6133 2314-6141
DOI:	10.1155/2015/294024