Search Results - "Moyer, Sydney M"

Integrated clinical and genomic analysis identifies driver events and molecular evolution of colitis-associated cancers by Chatila, Walid K., Walch, Henry, Hechtman, Jaclyn F., Moyer, Sydney M., Sgambati, Valeria, Faleck, David M., Srivastava, Amitabh, Tang, Laura, Benhamida, Jamal, Ismailgeci, Dorina, Campos, Carl, Wu, Fan, Chang, Qing, Vakiani, Efsevia, de Stanchina, Elisa, Weiser, Martin R., Widmar, Maria, Yantiss, Rhonda K., Shah, Manish A., Bass, Adam J., Stadler, Zsofia K., Katz, Lior H., Mellinghoff, Ingo K., Sethi, Nilay S., Schultz, Nikolaus, Ganesh, Karuna, Kelsen, David, Yaeger, Rona

“…Inflammation has long been recognized to contribute to cancer development, particularly across the gastrointestinal tract. Patients with inflammatory bowel…”
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Daxx maintains endogenous retroviral silencing and restricts cellular plasticity in vivo by Wasylishen, Amanda R, Sun, Chang, Moyer, Sydney M, Qi, Yuan, Chau, Gilda P, Aryal, Neeraj K, McAllister, Florencia, Kim, Michael P, Barton, Michelle C, Estrella, Jeannelyn S, Su, Xiaoping, Lozano, Guillermina

“…Tumor sequencing studies have emphasized the role of epigenetics and altered chromatin homeostasis in cancer. Mutations in , which encodes a chaperone for the…”
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VRK1 as a synthetic lethal target in VRK2 promoter-methylated cancers of the nervous system by So, Jonathan, Mabe, Nathaniel W, Englinger, Bernhard, Chow, Kin-Hoe, Moyer, Sydney M, Yerrum, Smitha, Trissal, Maria C, Marques, Joana G, Kwon, Jason J, Shim, Brian, Pal, Sangita, Panditharatna, Eshini, Quinn, Thomas, Schaefer, Daniel A, Jeong, Daeun, Mayhew, David L, Hwang, Justin, Beroukhim, Rameen, Ligon, Keith L, Stegmaier, Kimberly, Filbin, Mariella G, Hahn, William C

“…Collateral lethality occurs when loss of a gene/protein renders cancer cells dependent on its remaining paralog. Combining genome-scale CRISPR/Cas9…”
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p53 drives a transcriptional program that elicits a non-cell-autonomous response and alters cell state in vivo by Moyer, Sydney M., Wasylishen, Amanda R., Qi, Yuan, Fowlkes, Natalie, Su, Xiaoping, Lozano, Guillermina

“…Cell stress and DNA damage activate the tumor suppressor p53, triggering transcriptional activation of a myriad of target genes. The molecular, morphological,…”
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Triple-negative breast tumors are dependent on mutant p53 for growth and survival by Dibra, Denada, Moyer, Sydney M, El-Naggar, Adel K, Qi, Yuan, Su, Xiaoping, Lozano, Guillermina

“…The tumor suppressor gene is mutated early in the majority of patients with triple-negative breast cancer (TNBC). The most frequent alterations are missense…”
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A Ubiquitination Cascade Regulating the Integrated Stress Response and Survival in Carcinomas by Cervia, Lisa D, Shibue, Tsukasa, Borah, Ashir A, Gaeta, Benjamin, He, Linh, Leung, Lisa, Li, Naomi, Moyer, Sydney M, Shim, Brian H, Dumont, Nancy, Gonzalez, Alfredo, Bick, Nolan R, Kazachkova, Mariya, Dempster, Joshua M, Krill-Burger, John Michael, Piccioni, Federica, Udeshi, Namrata D, Olive, Meagan E, Carr, Steven A, Root, David E, McFarland, James M, Vazquez, Francisca, Hahn, William C

“…Systematic identification of signaling pathways required for the fitness of cancer cells will facilitate the development of new cancer therapies. We used gene…”
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Synergistic and additive effect of retinoic acid in circumventing resistance to p53 restoration by Larsson, Connie A., Moyer, Sydney M., Liu, Bin, Michel, Keith A., Pant, Vinod, Yang, Peirong, Wong, Justin, El-Naggar, Adel K., Krahe, Ralf, Lozano, Guillermina

“…TP53 mutations occur in ∼50% of all human tumors, with increased frequency in aggressive cancers that are notoriously difficult to treat. Additionally, p53…”
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Mutant p53 protects triple-negative breast adenocarcinomas from ferroptosis in vivo by Dibra, Denada, Xiong, Shunbin, Moyer, Sydney M, El-Naggar, Adel K, Qi, Yuan, Su, Xiaoping, Kong, Elisabeth K, Korkut, Anil, Lozano, Guillermina

“…The tumor suppressor gene is mutated early in most of the patients with triple-negative breast cancer (TNBC). The most frequent alterations are missense…”
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Aberrant cell state plasticity mediated by developmental reprogramming precedes colorectal cancer initiation by Bala, Pratyusha, Rennhack, Jonathan P, Aitymbayev, Daulet, Morris, Clare, Moyer, Sydney M, Duronio, Gina N, Doan, Paul, Li, Zhixin, Liang, Xiaoyan, Hornick, Jason L, Yurgelun, Matthew B, Hahn, William C, Sethi, Nilay S

“…Cell state plasticity is carefully regulated in adult epithelia to prevent cancer. The aberrant expansion of the normally restricted capability for cell state…”
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Mdm proteins: critical regulators of embryogenesis and homoeostasis by Moyer, Sydney M., Larsson, Connie A., Lozano, Guillermina

“…Mdm2 and Mdm4 are negative regulators of the tumour suppressor p53; hence, this relationship is the focus of many cancer-related studies. A multitude of…”
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Abstract 2361: MYC-driven breast cancer tumorigenesis is dependent on normal mitochondrial function by Moyer, Sydney M., Ilic, Nina, Gang, Sydney, Arnoff, Taylor E., Hahn, William C.

“…Abstract While the transcription factor MYC is amplified in all breast cancer subtypes, nearly 60% of patients with triple-negative tumors have elevated MYC…”
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Abstract PR012: Aberrant cell state plasticity mediates colorectal cancer initiation by Bala, Pratyusha, Rennhack, Jonathan, Morris, Clare, Aitymbayev, Daulet, Moyer, Sydney M., Duronio, Gina N., Hahn, William, Sethi, Nilay S.

“…Abstract Cell state plasticity – the ability of cells to acquire new states via differentiation programs - is an important feature of embryogenesis, allowing…”
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Mdm proteins： critical regulators of embryogenesis and hornoeostasis by Sydney M. Moyer Connie A. Larsson Guillermina Lozano

“…Mdm2 and Mdm4 are negative regulators of the tumour suppressor p53; hence, this relationship is the focus of many cancerrelated studies. A multitude of…”
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Abstract B023: Sox9 drives an aberrant transcriptional program impeding intestinal differentiation in colorectal cancer initiation by Bala, Pratyusha, Rennhack, Jonathan P., Morris, Clare, Aitymbayev, Daulet, Moyer, Sydney M., Duronio, Gina Nicole, Doan, Paul, Hahn, William C., Sethi, Nilay S.

“…Abstract Despite the implementation of screening and preventative strategies, colorectal cancer (CRC) remains the second most deadly cancer worldwide and is…”
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Mdm proteins: critical regulators of embry ogenesis and homeostasis by Moyer, Sydney M, Larsson, Connie A, Lozano, Guillermina

“…Mdm2 and Mdm4 are negative regulators of the tumor suppressor p53; hence, this relationship is the focus of many cancer related studies. A multitude of…”
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