Search Results - "Moyer, James D"

Combination Therapy Enhances the Inhibition of Tumor Growth with the Fully Human Anti–Type 1 Insulin-Like Growth Factor Receptor Monoclonal Antibody CP-751,871 by COHEN, Bruce D, BAKER, Deborah A, MOYER, James D, SODERSTROM, Catherine, TKALCEVIC, George, ROSSI, Ann Marie, MILLER, Penny E, TENGOWSKI, Mark W, WANG, Faye, GUALBERTO, Antonio, BEEBE, Jean S

“…Purpose: The insulin-like growth factor (IGF) signaling pathway is implicated in cellular mitogenesis, angiogenesis, tumor cell survival, and tumorigenesis…”
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PF-03814735, an orally bioavailable small molecule aurora kinase inhibitor for cancer therapy by Jani, Jitesh P, Arcari, Joel, Bernardo, Vincent, Bhattacharya, Samit K, Briere, David, Cohen, Bruce D, Coleman, Kevin, Christensen, James G, Emerson, Erling O, Jakowski, Amy, Hook, Kenneth, Los, Gerrit, Moyer, James D, Pruimboom-Brees, Ingrid, Pustilnik, Leslie, Rossi, Ann Marie, Steyn, Stefan J, Su, Chunyan, Tsaparikos, Konstantinos, Wishka, Donn, Yoon, Kwansik, Jakubczak, John L

“…The Aurora family of highly related serine/threonine kinases plays a key role in the regulation of mitosis. Aurora1 and Aurora2 play important but distinct…”
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The discovery of highly selective erbB2 (Her2) inhibitors for the treatment of cancer by Lippa, Blaise, Kauffman, Goss S., Arcari, Joel, Kwan, Tricia, Chen, Jinshan, Hungerford, William, Bhattacharya, Samit, Zhao, Xumiao, Williams, Courtney, Xiao, Jun, Pustilnik, Leslie, Su, Chunyan, Moyer, James D., Ma, Ling, Campbell, Mary, Steyn, Stefanus

“…The synthesis and biological evaluation of potent and selective inhibitors of the erbB2 kinase is presented. The vast majority of these compounds are found to…”
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Prevention of Organ Allograft Rejection by a Specific Janus Kinase 3 Inhibitor by Changelian, Paul S., Flanagan, Mark E., Ball, Douglas J., Kent, Craig R., Magnuson, Kelly S., Martin, William H., Rizzuti, Bonnie J., Sawyer, Perry S., Perry, Bret D., Brissette, William H., McCurdy, Sandra P., Kudlacz, Elizabeth M., Conklyn, Maryrose J., Elliott, Eileen A., Koslov, Erika R., Fisher, Michael B., Strelevitz, Timothy J., Yoon, Kwansik, Whipple, David A., Sun, Jianmin, Munchhof, Michael J., Doty, John L., Casavant, Jeffrey M., Blumenkopf, Todd A., Hines, Michael, Brown, Matthew F., Lillie, Brett M., Subramanyam, Chakrapani, Shang-Poa, Chang, Milici, Anthony J., Beckius, Gretchen E., Moyer, James D., Su, Chunyan, Woodworth, Thasia C., Gaweco, Anderson S., Beals, Chan R., Littman, Bruce H., Fisher, Douglas A., Smith, James F., Zagouras, Panayiotis, Magna, Holly A., Saltarelli, Mary J., Johnson, Kimberly S., Nelms, Linda F., Shelley G. Des Etages, Hayes, Lisa S., Kawabata, Thomas T., Finco-Kent, Deborah, Baker, Deanna L., Larson, Michael, Si, Ming-Sing, Paniagua, Ricardo, Higgins, John, Holm, Bari, Reitz, Bruce, Zhou, Yong-Jie, Morris, Randall E., O'Shea, John J., Borie, Dominic C.

“…Because of its requirement for signaling by multiple cytokines, Janus kinase 3 (JAK3) is an excellent target for clinical immunosuppression. We report the…”
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Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitor by JANI, Jitesh P, FINN, Richard S, MORRIS, Joel, MOYER, James D, PUSTILNIK, Leslie R, RAFIDI, Kristina, RALSTON, Sherry, ROSSI, Ann Marie K, STEYN, Stefanus J, WAGNER, Larry, WINTER, Steven M, BHATTACHARYA, Samit K, CAMPBELL, Mary, COLEMAN, Kevin G, CONNELL, Richard D, CURRIER, Nicolas, EMERSON, Erling O, FLOYD, Eugenia, HARRIMAN, Shawn, KATH, John C

“…Amplification and overexpression of erbB2 (Her-2/neu) proto-oncogene has been linked to human malignancies including tumors of the breast, ovary, and stomach…”
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Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase by MOYER, J. D, BARBACCI, E. G, NEVEU, M, POLLACK, V. A, PUSTILNIK, L. R, REYNOLDS, M. M, SLOAN, D, THELEMAN, A, MILLER, P, IWATA, K. K, ARNOLD, L, BOMAN, B, CUNNINGHAM, A, DIORIO, C, DOTY, J, MORIN, M. J, MOYER, M. P

“…The epidermal growth factor receptor (EGFR) is overexpressed in a significant percentage of carcinomas and contributes to the malignant phenotype. CP-358,774…”
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Inhibition of epidermal growth factor receptor-associated tyrosine phosphorylation in human carcinomas with CP-358,774: dynamics of receptor inhibition in situ and antitumor effects in athymic mice by Pollack, V A, Savage, D M, Baker, D A, Tsaparikos, K E, Sloan, D E, Moyer, J D, Barbacci, E G, Pustilnik, L R, Smolarek, T A, Davis, J A, Vaidya, M P, Arnold, L D, Doty, J L, Iwata, K K, Morin, M J

“…Phosphorylation of tyrosine residues on the epidermal growth factor (EGF) receptor (EGFr) is an important early event in signal transduction, leading to cell…”
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Bivalence of EGF-like ligands drives the ErbB signaling network by Tzahar, Eldad, Pinkas-Kramarski, Ronit, Moyer, James D., Klapper, Leah N., Alroy, Iris, Levkowitz, Gil, Shelly, Maya, Henis, Sivan, Eisenstein, Miriam, Ratzkin, Barry J., Sela, Michael, Andrews, Glenn C., Yarden, Yosef

“…Signaling by epidermal growth factor (EGF)‐like ligands is mediated by an interactive network of four ErbB receptor tyrosine kinases, whose mechanism of…”
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ErbB Tyrosine Kinases and the Two Neuregulin Families Constitute a Ligand-Receptor Network by Pinkas-Kramarski, Ronit, Shelly, Maya, Guarino, Bradley C., Wang, Ling Mei, Lyass, Ljuba, Alroy, Iris, Alamandi, Mauricio, Kuo, Angera, Moyer, James D., Lavi, Sara, Eisenstein, Miriam, Ratzkin, Barry J., Seger, Rony, Bacus, Sarah S., Pierce, Jacalyn H., Andrews, Glenn C., Yarden, Yosef

“…AUTHOR'S CORRECTION ( vol. 19 , p. 8695 ) ERRATUM ( vol. 18 , p. 7602 ) Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content…”
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The biological and biochemical effects of CP-654577, a selective erbB2 kinase inhibitor, on human breast cancer cells by BARBACCI, E. Gabriella, PUSTILNIK, Leslie R, KATH, John C, ZHENGYU LIU, MOYER, James D, ROSSI, Ann Marie K, EMERSON, Erling, MILLER, Penny E, BOSCOE, Brian P, COX, Eric D, IWATA, Kenneth K, JANI, Jitesh P, PROVONCHA, Kathleen

“…Aberrant expression or activity of epidermal growth factor receptor (EGFr) or the closely related p185(erbB2) can promote cell proliferation and survival and…”
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Pathogenic poxviruses reveal viral strategies to exploit the ErbB signaling network by Tzahar, Eldad, Moyer, James D., Waterman, Hadassa, Barbacci, Elsa G., Bao, Jing, Levkowitz, Gil, Shelly, Maya, Strano, Sabrina, Pinkas-Kramarski, Ronit, Pierce, Jacalyn H., Andrews, Glenn C., Yarden, Yosef

“…Virulence of poxviruses, the causative agents of smallpox, depends on virus‐encoded growth factors related to the mammalian epidermal growth factor (EGF). Here…”
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LAS, a novel selective estrogen receptor modulator with chemopreventive and therapeutic activity in the N-nitroso-N-methylurea-induced rat mammary tumor model by COHEN, Leonard A, PITTMAN, Brian, WANG, Chung-Xiou, ALIAGA, César, LI YU, MOYER, James D

“…The N-nitroso-N-methylurea-induced rat mammary tumor model was used to conduct two types of studies: a prevention study designed to test the ability of the…”
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Novel Single-Pass Exchange of Circulating Uridine in Rat Liver by Gasser, Thomas, Moyer, James D., Handschumacher, Robert E.

“…Evidence is presented that the liver effects an essentially complete degradation of plasma uridine in a single pass and replaces it largely from hepatic pools…”
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Achieving selectivity between highly homologous tyrosine kinases: a novel selective erbB2 inhibitor by Bhattacharya, Samit K., Cox, Eric D., Kath, John C., Mathiowetz, Alan M., Morris, Joel, Moyer, James D., Pustilnik, Leslie R., Rafidi, Kris, Richter, Daniel T., Su, Chunyan, Wessel, Matthew D.

“…The discovery of small molecule kinase inhibitors for use as drugs is a promising approach for the treatment of cancer and other diseases, but the discovery of…”
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The Structural Basis for the Specificity of Epidermal Growth Factor and Heregulin Binding by Barbacci, E G, Guarino, B C, Stroh, J G, Singleton, D H, Rosnack, K J, Moyer, J D, Andrews, G C

“…Heregulin is a ligand for the erb B3 and erb B4 receptors, with a region of high homology to epidermal growth factor (EGF). Despite this homology, these…”
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Antitumor activity and biochemical effects of aphidicolin glycinate (NSC 303812) alone and in combination with cisplatin in vivo by O'DWYER, P. J, MOYER, J. D, SUFFNESS, M, HARRISON, S. D, CYSYK, R, HAMILTON, T. C, PLOWMAN, J

“…Aphidicolin, an inhibitor of DNA polymerases alpha and delta, is cytotoxic in vitro against tumor cells. The poor solubility of aphidicolin has led to the…”
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Synthesis, biological testing, and stereochemical assignment of an end group modified retro-inverso bombesin C-terminal nonapeptide by Cushman, Mark, Jurayj, Jurjus, Moyer, James D

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Salvage of circulating pyrimidine nucleosides in the rat by Moyer, J D, Oliver, J T, Handschumacher, R E

“…A new procedure was developed to measure uridine and cytidine in plasma. These nucleosides are present in micromolar concentrations in the plasma of rats,…”
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Cyclopentenyluridine and cyclopentenylcytidine analogs as inhibitors of uridine-cytidine kinase by Lim, Mu Ill, Moyer, James D, Cysyk, Richard L, Marquez, Victor E

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Antitumor activity and biochemical effects of cyclopentenyl cytosine in mice by MOYER, J. D, MALINOWSKI, N. M, TREANOR, S. P, MARQUEZ, V. E

“…Cyclopentenyl cytosine, a recently synthesized inhibitor of cytidine 5'-triphosphate synthesis, has marked antitumor activity. Treatment with 1 mg/kg i.p. on…”
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