Search Results - "Moyano‐Galceran, Lidia"

Adaptive RSK‐EphA2‐GPRC5A signaling switch triggers chemotherapy resistance in ovarian cancer by Moyano‐Galceran, Lidia, Pietilä, Elina A, Turunen, S Pauliina, Corvigno, Sara, Hjerpe, Elisabet, Bulanova, Daria, Joneborg, Ulrika, Alkasalias, Twana, Miki, Yuichiro, Yashiro, Masakazu, Chernenko, Anastasiya, Jukonen, Joonas, Singh, Madhurendra, Dahlstrand, Hanna, Carlson, Joseph W, Lehti, Kaisa

“…Metastatic cancers commonly activate adaptive chemotherapy resistance, attributed to both microenvironment‐dependent phenotypic plasticity and genetic…”
Get full text

Aggressive and recurrent ovarian cancers upregulate ephrinA5, a non-canonical effector of EphA2 signaling duality by Jukonen, Joonas, Moyano-Galceran, Lidia, Höpfner, Katrin, Pietilä, Elina A., Lehtinen, Laura, Huhtinen, Kaisa, Gucciardo, Erika, Hynninen, Johanna, Hietanen, Sakari, Grénman, Seija, Ojala, Päivi M., Carpén, Olli, Lehti, Kaisa

“…Erythropoietin producing hepatocellular (Eph) receptors and their membrane-bound ligands ephrins are variably expressed in epithelial cancers, with…”
Get full text

Mechanical Confinement and DDR1 Signaling Synergize to Regulate Collagen‐Induced Apoptosis in Rhabdomyosarcoma Cells by Gonzalez‐Molina, Jordi, Kirchhof, Katharina Miria, Rathod, Bhavik, Moyano‐Galceran, Lidia, Calvo‐Noriega, Maria, Kokaraki, Georgia, Bjørkøy, Astrid, Ehnman, Monika, Carlson, Joseph W., Lehti, Kaisa

“…Fibrillar collagens promote cell proliferation, migration, and survival in various epithelial cancers and are generally associated with tumor aggressiveness…”
Get full text

FOXP3+ T cells in uterine sarcomas are associated with favorable prognosis, low extracellular matrix expression and reduced YAP activation by Gultekin, Okan, Gonzalez-Molina, Jordi, Hardell, Elin, Moyano-Galceran, Lidia, Mitsios, Nicholas, Mulder, Jan, Kokaraki, Georgia, Isaksson, Anders, Sarhan, Dhifaf, Lehti, Kaisa, Carlson, Joseph W.

“…Uterine sarcomas are rare but deadly malignancies without effective treatment. Immunotherapy is a promising new approach to treat these tumors but has shown…”
Get full text

Fibroblasts in the Tumor Microenvironment: Shield or Spear? by Alkasalias, Twana, Moyano-Galceran, Lidia, Arsenian-Henriksson, Marie, Lehti, Kaisa

“…Tumorigenesis is a complex process involving dynamic interactions between malignant cells and their surrounding stroma, including both the cellular and…”
Get full text

Co-evolution of matrisome and adaptive adhesion dynamics drives ovarian cancer chemoresistance by Pietilä, Elina A., Gonzalez-Molina, Jordi, Moyano-Galceran, Lidia, Jamalzadeh, Sanaz, Zhang, Kaiyang, Lehtinen, Laura, Turunen, S. Pauliina, Martins, Tomás A., Gultekin, Okan, Lamminen, Tarja, Kaipio, Katja, Joneborg, Ulrika, Hynninen, Johanna, Hietanen, Sakari, Grénman, Seija, Lehtonen, Rainer, Hautaniemi, Sampsa, Carpén, Olli, Carlson, Joseph W., Lehti, Kaisa

“…Due to its dynamic nature, the evolution of cancer cell-extracellular matrix (ECM) crosstalk, critically affecting metastasis and treatment resistance, remains…”
Get full text

Chemotherapy as a regulator of extracellular matrix-cell communication: Implications in therapy resistance by Gonzalez-Molina, Jordi, Moyano-Galceran, Lidia, Single, Andrew, Gultekin, Okan, Alsalhi, Shno, Lehti, Kaisa

“…The development of most solid cancers, including pancreatic, breast, lung, liver, and ovarian cancer, involves a desmoplastic reaction: a process of major…”
Get full text

Crosstalk Between Cancer Associated Fibroblasts and Cancer Cells in Scirrhous Type Gastric Cancer by Miki, Yuichiro, Yashiro, Masakazu, Moyano-Galceran, Lidia, Sugimoto, Atsushi, Ohira, Masaichi, Lehti, Kaisa

“…Gastric cancer (GC) is the third leading cause among all cancer deaths globally. Although the treatment outcome of GC has improved, the survival of patients…”
Get full text

Single-cell transcriptomes identify patient-tailored therapies for selective co-inhibition of cancer clones by Ianevski, Aleksandr, Nader, Kristen, Driva, Kyriaki, Senkowski, Wojciech, Bulanova, Daria, Moyano-Galceran, Lidia, Ruokoranta, Tanja, Kuusanmäki, Heikki, Ikonen, Nemo, Sergeev, Philipp, Vähä-Koskela, Markus, Giri, Anil K., Vähärautio, Anna, Kontro, Mika, Porkka, Kimmo, Pitkänen, Esa, Heckman, Caroline A., Wennerberg, Krister, Aittokallio, Tero

“…Intratumoral cellular heterogeneity necessitates multi-targeting therapies for improved clinical benefits in advanced malignancies. However, systematic…”
Get full text

Molecular, cellular and systemic aspects of epithelial ovarian cancer and its tumor microenvironment by Schoutrop, Esther, Moyano-Galceran, Lidia, Lheureux, Stephanie, Mattsson, Jonas, Lehti, Kaisa, Dahlstrand, Hanna, Magalhaes, Isabelle

“…Ovarian cancer encompasses a heterogeneous group of malignancies that involve the ovaries, fallopian tubes and the peritoneal cavity. Despite major advances…”
Get full text

Mesothelin-specific CAR T cells target ovarian cancer by Schoutrop, Esther, El-Serafi, Ibrahim, Poiret, Thomas, Zhao, Ying, Gultekin, Okan, He, Rui, Moyano-Galceran, Lidia, Carlson, Joseph W, Lehti, Kaisa, Hassan, Moustapha, Magalhaes, Isabelle, Mattsson, Jonas

“…New therapeutic options for patients with ovarian cancer are urgently needed. Therefore, we evaluated the efficacy of two second-generation mesothelin…”
Get full text

Abstract PO050: EphA2 signaling segregation and modulation by diverse tumor microenvironment components differentially regulates cancer cell invasion and survival by Moyano-Galceran, Lidia, Turunen, Pauliina S., Sugiyama, Nami, von Nandelstadh, Pernilla, Gucciardo, Erika, Varjosalo, Markku, Lehti, Kaisa

“…Abstract The receptor tyrosine kinase EphA2 is overexpressed in many solid cancers and associated with disease aggressiveness and poor clinical outcome. EphA2…”
Get full text

Abstract GMM-041: OVARIAN CANCER CELLS INDUCE A FEEDBACK RESPONSE TO PLATINUM-BASED CHEMOTHERAPY BY ACTIVATING AN ONCOGENIC RSK-EPHA2-GPRC5A SIGNALING SWITCH by Moyano-Galceran, Lidia, Turunen, Siri Pauliina, Pietilä, Elina, Alkasalias, Twana, Corvigno, Sara, Hjerpe, Elisabet, Joneborg, Ulrika, Bulanova, Daria, Eriksson, Mina, Dahlstrand, Hanna, Carlson, Joseph, Lehti, Kaisa

“…Abstract Despite increased understanding of chemotherapy resistance, the effects of the chemotherapy itself on the oncogenic cancer cell properties and…”
Get full text

Efficacy and safety of glycosphingolipid SSEA-4 targeting CAR-T cells in an ovarian carcinoma model by Monzo, Hector J, Kalander, Kerttu, Hyytiäinen, Marko M, Elbasani, Endrit, Wall, Johanna, Moyano-Galceran, Lidia, Tanjore Ramanathan, Jayendrakishore, Jukonen, Joonas J J, Laakkonen, Pirjo, Ristimäki, Ari, Carlson, Joseph W, Lehti, Kaisa, Salehi, Sahar, Puolakkainen, Pauli, Haglund, Caj, Seppänen, Hanna, Leppä, Sirpa, Ojala, Päivi M

“…Chimeric antigen receptor (CAR) T-cell immunotherapies for solid tumors face critical challenges such as heterogeneous antigen expression. We characterized…”
Get full text

Thermal Proteome Profiling Identifies Oxidative-Dependent Inhibition of the Transcription of Major Oncogenes as a New Therapeutic Mechanism for Select Anticancer Compounds by Peuget, Sylvain, Zhu, Jiawei, Sanz, Gema, Singh, Madhurendra, Gaetani, Massimiliano, Chen, Xinsong, Shi, Yao, Saei, Amir Ata, Visnes, Torkild, Lindström, Mikael S, Rihani, Ali, Moyano-Galceran, Lidia, Carlson, Joseph W, Hjerpe, Elisabet, Joneborg, Ulrika, Lehti, Kaisa, Hartman, Johan, Helleday, Thomas, Zubarev, Roman, Selivanova, Galina

“…Identification of the molecular mechanism of action (MoA) of bioactive compounds is a crucial step for drug development but remains a challenging task despite…”
Get full text

Receptor Tyrosine Kinase Signaling and Extracellular Matrix Cues in Ovarian Cancer Metastasis and Drug Resistance by Moyano Galceran, Lidia

“…Albeit many studies have contributed towards understanding the origin, development, treatment response and evolution of high-grade serous ovarian carcinoma…”
Get full text

Abstract A64: Extracellular matrix proteins increase invasive growth and chemotherapy resistance of ovarian cancer cells by Pietilä, Elina A., Gonzales-Molina, Jordi, Moyano-Galceran, Lidia, Lehtinen, Laura, Turunen, Pauliina, Martins, Tomas Santos, Rantanen, Ville, Häkkinen, Antti, Jamalzadeh, Sanaz, Zhang, Kaiyang, Lamminen, Tarja, Kaipio, Katja, Hynninen, Johanna, Hietanen, Sakari, Grénman, Seija, Lehtonen, Rainer, Hautaniemi, Sampsa, Carpén, Olli, Lehti, Kaisa

“…Abstract Extracellular matrix (ECM) interactions contribute to cancer metastasis and chemotherapy resistance by regulating invasive cancer growth and apoptosis…”
Get full text

Integrated Molecular Analysis of Undifferentiated Uterine Sarcomas Reveals Clinically Relevant Molecular Subtypes by Binzer-Panchal, Amrei, Hardell, Elin, Viklund, Björn, Ghaderi, Mehran, Bosse, Tjalling, Nucci, Marisa R, Lee, Cheng-Han, Hollfelder, Nina, Corcoran, Pádraic, Gonzalez-Molina, Jordi, Moyano-Galceran, Lidia, Bell, Debra A, Schoolmeester, John K, Måsbäck, Anna, Kristensen, Gunnar B, Davidson, Ben, Lehti, Kaisa, Isaksson, Anders, Carlson, Joseph W

“…Undifferentiated uterine sarcomas (UUS) are rare, extremely deadly, sarcomas with no effective treatment. The goal of this study was to identify novel…”
Get full text