Validation of a rabbit model of neuropathy induced by immunization with gangliosides

Abstract The induction of neurological signs by immunization of rabbits with gangliosides has been a controversial topic for many years. Recently, Yuki et al. [N. Yuki, M. Yamada, M. Koga, M. Odaka, K. Susuki, Y. Tagawa, et al. Animal model of axonal Guillain–Barré syndrome induced by sensitization...

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Bibliographic Details
Published in:	Journal of the neurological sciences Vol. 272; no. 1; pp. 110 - 114
Main Authors:	Moyano, A.L, Comín, R, Lardone, R.D, Alaniz, M.E, Theaux, R, Irazoqui, F.J, Nores, G.A
Format:	Journal Article
Language:	English
Published:	Shannon Elsevier B.V 15-09-2008 Elsevier Science
Subjects:	Animals Anti-GM1 antibodies Biological and medical sciences Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction Disease Models, Animal Experimental neuropathy Ganglioside Gangliosides - immunology Guillain-Barre Syndrome - etiology Guillain-Barre Syndrome - immunology Guillain–Barré Immunization - adverse effects Male Medical sciences Nervous system (semeiology, syndromes) Neurology Peripheral Nerves - pathology Rabbits syndrome Time Factors Anti-GM1 antibodies Ganglioside Experimental neuropathy syndrome Guillain–Barré Validation Guillain-Barré Immunization Nervous system diseases Rabbit Neuropathy Lagomorpha Guillain-Barré syndrome Inflammatory disease Vertebrata Mammalia Animal Models Peripheral nerve disease
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Summary:	Abstract The induction of neurological signs by immunization of rabbits with gangliosides has been a controversial topic for many years. Recently, Yuki et al. [N. Yuki, M. Yamada, M. Koga, M. Odaka, K. Susuki, Y. Tagawa, et al. Animal model of axonal Guillain–Barré syndrome induced by sensitization with GM1 ganglioside. Ann Neurol 2001;49:712–720.] described an immunization protocol, including keyhole lympet hemocyanin in addition to ganglioside that induced a neurological disease resembling human Guillain–Barré syndrome. We employed this protocol in our laboratory and succeeded in reproducing the disease. Five different experiments were performed during a period of two years by different operators, using different batches of drugs, in a total of 26 rabbits. Despite minor variations in onset time and severity of the induced disease, the model proved to be reproducible. Both gangliosides and keyhole limpet hemocyanin are required for induction of disease.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	0022-510X 1878-5883
DOI:	10.1016/j.jns.2008.05.006