Search Results - "Moxley, Michael"

Detailed evaluation of pyruvate dehydrogenase complex inhibition in simulated exercise conditions by Jelinek, Bodhi A., Moxley, Michael A.

“…The mammalian pyruvate dehydrogenase complex (PDC) is a mitochondrial multienzyme complex that connects glycolysis to the tricarboxylic acid cycle by…”
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DJ‐1 is not a deglycase and makes a modest contribution to cellular defense against methylglyoxal damage in neurons by Mazza, Melissa Conti, Shuck, Sarah C., Lin, Jiusheng, Moxley, Michael A., Termini, John, Cookson, Mark R., Wilson, Mark A.

“…Human DJ‐1 is a cytoprotective protein whose absence causes Parkinson's disease and is also associated with other diseases. DJ‐1 has an established role as a…”
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Luminol-Based Chemiluminescent Signals: Clinical and Non-clinical Application and Future Uses by Khan, Parvez, Idrees, Danish, Moxley, Michael A., Corbett, John A., Ahmad, Faizan, von Figura, Guido, Sly, William S., Waheed, Abdul, Hassan, Md. Imtaiyaz

“…Chemiluminescence (CL) is an important method for quantification and analysis of various macromolecules. A wide range of CL agents such as luminol, hydrogen…”
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AANAT kinetics of CoASH-targeted electrophiles of tryptamine and related analogs by Wandrey, Nicole, Hamilton, Luke, Boley, Jake, Haynes, Alexis, Redinger, Makenna, Hill, Mackinzi, Hagemeister, Mackenzie, Cole, Philip A., Moxley, Michael A., Thomas, Allen A.

“…[Display omitted] •Bromoacetyltryptamine (BAT) was more potent than Michael acceptor analogs in an AANAT enzymatic assay.•A two-carbon linker connecting…”
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Computationally modeling mammalian succinate dehydrogenase kinetics identifies the origins and primary determinants of ROS production by Manhas, Neeraj, Duong, Quynh V., Lee, Pilhwa, Richardson, Joshua D., Robertson, John D., Moxley, Michael A., Bazil, Jason N.

“…Succinate dehydrogenase (SDH) is an inner mitochondrial membrane protein complex that links the Krebs cycle to the electron transport system. It can produce…”
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Evidence of a preferred kinetic pathway in the carnitine acetyltransferase reaction by Kratochvil, Michael J., Balerud, Nick K., Schindler, Samantha J., Moxley, Michael A.

“…Mammalian carnitine acetyltransferase (CrAT) is a mitochondrial enzyme that catalyzes the reversible transfer of an acetyl group from acetyl-CoA to carnitine…”
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Educational guidelines for diversity and inclusion: addressing racism and eliminating biases in medical education by Buery-Joyner, Samantha D., Baecher-Lind, Laura, Clare, Camille A., Hampton, B. Star, Moxley, Michael D., Ogunyemi, Dotun, Pradhan, Archana A., Madani Sims, Shireen M., Whetstone, Sara, Woodland, Mark B., Katz, Nadine T.

“…Racism and bias contribute to healthcare disparities at a patient and population health level and also contribute to the stagnation or even regression of…”
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Systems-level computational modeling demonstrates fuel selection switching in high capacity running and low capacity running rats by Moxley, Michael A, Vinnakota, Kalyan C, Bazil, Jason N, Qi, Nathan R, Beard, Daniel A

“…High capacity and low capacity running rats, HCR and LCR respectively, have been bred to represent two extremes of running endurance and have recently…”
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A pH-Dependent Kinetic Model of Dihydrolipoamide Dehydrogenase from Multiple Organisms by Moxley, Michael A., Beard, Daniel A., Bazil, Jason N.

“…Dihydrolipoamide dehydrogenase is a flavoenzyme that reversibly catalyzes the oxidation of reduced lipoyl substrates with the reduction of NAD+ to NADH…”
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Evaluation of Rhodanine Indolinones as AANAT Inhibitors by Hagemeister, Mackenzie, Hamilton, Luke, Wandrey, Nicole, Hill, Mackinzi, Mounce, Emery, Mosel, Noah, Lytle, Katie, Redinger, Makenna, Boley, Jake, Fancher, Nathan, Haynes, Alexis, Fill, Ianna, Cole, Philip A., Hill, Evan, Moxley, Michael A., Thomas, Allen A.

“…Circadian rhythm (CR) dysregulation negatively impacts health and contributes to mental disorders. The role of melatonin, a hormone intricately linked to CR,…”
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Rapid Reaction Kinetics of Proline Dehydrogenase in the Multifunctional Proline Utilization A Protein by Moxley, Michael A, Becker, Donald F

“…The multifunctional proline utilization A (PutA) flavoenzyme from Escherichia coli catalyzes the oxidation of proline to glutamate in two reaction steps using…”
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Steady-state kinetic mechanism of the proline:ubiquinone oxidoreductase activity of proline utilization A (PutA) from Escherichia coli by Moxley, Michael A., Tanner, John J., Becker, Donald F.

“…► PutA displays activity with a variety of ubiquinone analogs. ► PutA catalyzes the proline:ubiquinone reaction via a two-site ping-pong mechanism. ► Kinetic…”
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Global Kinetic Analysis of Mammalian E3 Reveals pH-dependent NAD+/NADH Regulation, Physiological Kinetic Reversibility, and Catalytic Optimum by Moxley, Michael A., Beard, Daniel A., Bazil, Jason N.

“…Mammalian E3 is an essential mitochondrial enzyme responsible for catalyzing the terminal reaction in the oxidative catabolism of several metabolites. E3 is a…”
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The Three-Dimensional Structural Basis of Type II Hyperprolinemia by Srivastava, Dhiraj, Singh, Ranjan K., Moxley, Michael A., Henzl, Michael T., Becker, Donald F., Tanner, John J.

“…Type II hyperprolinemia is an autosomal recessive disorder caused by a deficiency in Δ1-pyrroline-5-carboxylate dehydrogenase (P5CDH; also known as ALDH4A1),…”
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A role for aberrant protein palmitoylation in FFA-induced ER stress and β-cell death by Baldwin, Aaron C, Green, Christopher D, Olson, L Karl, Moxley, Michael A, Corbett, John A

“…Exposure of insulin-producing cells to elevated levels of the free fatty acid (FFA) palmitate results in the loss of β-cell function and induction of…”
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Flavin redox switching of protein functions by Becker, Donald F, Zhu, Weidong, Moxley, Michael A

“…Flavin cofactors impart remarkable catalytic diversity to enzymes, enabling them to participate in a broad array of biological processes. The properties of…”
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Identification of a Conserved Histidine As Being Critical for the Catalytic Mechanism and Functional Switching of the Multifunctional Proline Utilization A Protein by Moxley, Michael A, Zhang, Lu, Christgen, Shelbi, Tanner, John J, Becker, Donald F

“…Proline utilization A from Escherichia coli (EcPutA) is a multifunctional flavoenzyme that oxidizes proline to glutamate through proline dehydrogenase (PRODH)…”
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Homogeneous Insulin and C-Peptide Sensors for Rapid Assessment of Insulin and C-Peptide Secretion by the Islets by HEYDUK, Ewa, MOXLEY, Michael M, SALVATORI, Alison, CORBETT, John A, HEYDUK, Tomasz

“…Glucose-stimulated islet insulin or C-peptide secretion experiments are a fundamental tool for studying and assessing islet function. The goal of this work was…”
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Factors Associated with Meeting Obstetric Care Consensus Guidelines for Nulliparous, Term, Singleton, Vertex Cesarean Births by Wang, Tiffany, Brown, Inga, Huang, Jim, Kawakita, Tetsuya, Moxley, Michael

“…Abstract Objective  This study aimed to identify factors associated with meeting the Obstetric Care Consensus (OCC) guidelines for nulliparous, term,…”
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Evidence for Hysteretic Substrate Channeling in the Proline Dehydrogenase and Δ1-Pyrroline-5-carboxylate Dehydrogenase Coupled Reaction of Proline Utilization A (PutA) by Moxley, Michael A., Sanyal, Nikhilesh, Krishnan, Navasona, Tanner, John J., Becker, Donald F.

“…PutA (proline utilization A) is a large bifunctional flavoenzyme with proline dehydrogenase (PRODH) and Δ1-pyrroline-5-carboxylate dehydrogenase (P5CDH)…”
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