Search Results - "Mower, Matthew P."
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Cavitands as Reaction Vessels and Blocking Groups for Selective Reactions in Water
Published in Angewandte Chemie International Edition (11-07-2016)“…The majority of reactions currently performed in the chemical industry take place in organic solvents, compounds that are generally derived from…”
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Journal Article -
2
Water-soluble cavitands promote hydrolyses of long-chain diesters
Published in Proceedings of the National Academy of Sciences - PNAS (16-08-2016)“…Water-soluble, deep cavitands serve as chaperones of long-chain diesters for their selective hydrolysis in aqueous solution. The cavitands bind the diesters in…”
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Journal Article -
3
Synthesis and Sulfur Electrophilicity of the Nuphar Thiaspirane Pharmacophore
Published in ACS central science (22-06-2016)“…We describe a general method to synthesize the iminium tetrahydrothiophene embedded in the dimeric Nuphar alkaloids. In contrast to prior studies, the sulfur…”
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Journal Article -
4
Automated Image-Based Color Analysis as an Accessible and Widely Applicable PAT Tool
Published in Organic process research & development (21-07-2023)“…Pharmaceutical R&D is increasingly employing data-driven approaches with specialized process analytical technology (PAT) tools to develop processes efficiently…”
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Journal Article -
5
Mechanistic Rationalization of Unusual Sigmoidal Kinetic Profiles in the Machetti–De Sarlo Cycloaddition Reaction
Published in Journal of the American Chemical Society (18-02-2015)“…Unusual sigmoidal kinetic profiles in the Machetti–De Sarlo base-catalyzed 1,3-dipolar cycloaddition of acrylamide to N-methylnitroacetamide are…”
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Journal Article -
6
Cavitands as Reaction Vessels and Blocking Groups for Selective Reactions in Water
Published in Angewandte Chemie (11-07-2016)“…The majority of reactions currently performed in the chemical industry take place in organic solvents, compounds that are generally derived from…”
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Journal Article -
7
In-Situ Monitoring of Enantiomeric Excess During a Catalytic Kinetic Resolution
Published in ACS catalysis (06-07-2018)“…Vibrational Circular Dichroism combined with FTIR spectroscopy (VCD-IR) is demonstrated as a viable tool for the in situ measurement of enantiomeric excess…”
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Journal Article -
8
Toward the Development of a Manufacturing Process for Milvexian: Scale-Up Synthesis of the Side Chain
Published in Organic process research & development (21-04-2023)“…Anticoagulants play a critical role in the prevention and treatment of thrombotic-driven cardiovascular diseases. Factor XIa (FXIa) inhibitors have the…”
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Journal Article -
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Reaction Kinetics and In-Situ Monitoring – Detailed Understanding of Reaction Mechanism through Analysis of the Full Reaction Profile
Published 01-01-2018“…Reaction monitoring using in-situ tools allows the straightforward acquisition of full reaction kinetic profiles. These profiles contain a wealth of…”
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Dissertation