Search Results - "Mowat, G."

Compensatory heterogeneity in spatially explicit capture-recapture data by Efford, M. G, Mowat, G

“…Spatially explicit capture-recapture methods, used widely to estimate the abundance of large carnivores, allow for movement within home ranges during sampling…”
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Human indoleamine 2,3-dioxygenase-2 has substrate specificity and inhibition characteristics distinct from those of indoleamine 2,3-dioxygenase-1 by Pantouris, Georgios, Serys, Martynas, Yuasa, Hajime J., Ball, Helen J., Mowat, Christopher G.

“…Indoleamine 2,3-dioxygenase-2 (IDO2) is one of three enzymes (alongside tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase (IDO1)) that catalyse…”
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The inflammatory microenvironment in colorectal neoplasia by McLean, Mairi H, Murray, Graeme I, Stewart, Keith N, Norrie, Gillian, Mayer, Claus, Hold, Georgina L, Thomson, John, Fyfe, Nicky, Hope, Mairi, Mowat, N Ashley G, Drew, Janice E, El-Omar, Emad M

“…Colorectal cancer (CRC) is a major cause of mortality and morbidity worldwide. Inflammatory activity within the stroma of invasive colorectal tumours is known…”
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Rising to the Challenge of Creating Equitable, Inclusive, and Compassionate School Communities in the Recovery Phase of the Pandemic: The Role of Aspiring Headteachers by Mowat, Joan G, Beck, Anna

“…Concerns have been raised globally about the impact of the pandemic on the mental health and wellbeing of children and young people (CYP). How prospective…”
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Structure and Reaction Mechanism in the Heme Dioxygenases by Efimov, Igor, Basran, Jaswir, Thackray, Sarah J, Handa, Sandeep, Mowat, Christopher G, Raven, Emma Lloyd

“…As members of the family of heme-dependent enzymes, the heme dioxygenases are differentiated by virtue of their ability to catalyze the oxidation of…”
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Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase by Hutchinson, Jonathan P., Rowland, Paul, Taylor, Mark R. D., Christodoulou, Erica M., Haslam, Carl, Hobbs, Clare I., Holmes, Duncan S., Homes, Paul, Liddle, John, Mole, Damian J., Uings, Iain, Walker, Ann L., Webster, Scott P., Mowat, Christopher G., Chung, Chun-wa

“…Kynurenine-3-monooxygenase (KMO) is a key FAD-dependent enzyme of tryptophan metabolism. In animal models, KMO inhibition has shown benefit in…”
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Exploring the mechanism of tryptophan 2,3-dioxygenase by Thackray, Sarah J, Mowat, Christopher G, Chapman, Stephen K

“…The haem proteins TDO (tryptophan 2,3-dioxygenase) and IDO (indoleamine 2,3-dioxygenase) are specific and powerful oxidation catalysts that insert one molecule…”
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The Mechanism of Substrate Inhibition in Human Indoleamine 2,3-Dioxygenase by Efimov, Igor, Basran, Jaswir, Sun, Xiao, Chauhan, Nishma, Chapman, Stephen K, Mowat, Christopher G, Raven, Emma Lloyd

“…Indoleamine 2,3-dioxygenase catalyzes the O2-dependent oxidation of l-tryptophan (l-Trp) to N-formylkynurenine (NFK) as part of the kynurenine pathway…”
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A Functional Polymorphism of Toll-Like Receptor 4 Gene Increases Risk of Gastric Carcinoma and Its Precursors by Hold, Georgina L, Rabkin, Charles S, Chow, Wong–Ho, Smith, Malcolm G, Gammon, Marilie D, Risch, Harvey A, Vaughan, Thomas L, McColl, Kenneth E.L, Lissowska, Jolanta, Zatonski, Witold, Schoenberg, Janet B, Blot, William J, Mowat, N. Ashley G, Fraumeni, Joseph F, El–Omar, Emad M

“…Background & Aims: TLR4 is a cell-surface signaling receptor involved in the recognition and host response to Helicobacter pylori . The TLR4 +896A>G…”
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Molecular insights into substrate recognition and catalysis by tryptophan 2,3-dioxygenase by Forouhar, Farhad, Anderson, J.L. Ross, Mowat, Christopher G, Vorobiev, Sergey M, Hussain, Arif, Abashidze, Mariam, Bruckmann, Chiara, Thackray, Sarah J, Seetharaman, Jayaraman, Tucker, Todd, Xiao, Rong, Ma, Li-Chung, Zhao, Li, Acton, Thomas B, Montelione, Gaetano T, Chapman, Stephen K, Tong, Liang

“…Tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO) constitute an important, yet relatively poorly understood, family of heme-containing…”
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An octaheme c-type cytochrome from Shewanella oneidensis can reduce nitrite and hydroxylamine by Atkinson, Sally J., Mowat, Christopher G., Reid, Graeme A., Chapman, Stephen K.

“…A c-type cytochrome from Shewanella oneidensis MR-1, containing eight hemes, has been previously designated as an octaheme tetrathionate reductase (OTR). The…”
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Reassessment of the Reaction Mechanism in the Heme Dioxygenases by Chauhan, Nishma, Thackray, Sarah J, Rafice, Sara A, Eaton, Graham, Lee, Michael, Efimov, Igor, Basran, Jaswir, Jenkins, Paul R, Mowat, Christopher G, Chapman, Stephen K, Raven, Emma Lloyd

“…Indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) are heme enzymes that catalyze the O2-dependent oxidation of l-tryptophan to…”
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How is the distal pocket of a heme protein optimized for binding of tryptophan? by Chauhan, Nishma, Basran, Jaswir, Rafice, Sara A., Efimov, Igor, Millett, Elizabeth S., Mowat, Christopher G., Moody, Peter C. E., Handa, Sandeep, Raven, Emma L.

“…Indoleamine 2,3‐dioxygenase and tryptophan 2,3‐dioxygenase catalyze the O2‐dependent oxidation of l‐tryptophan to N‐formylkynurenine. Both are heme‐containing…”
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Atomic Structure of Mycobacterium tuberculosis CYP121 to 1.06 Å Reveals Novel Features of Cytochrome P450 by Leys, David, Mowat, Christopher G, McLean, Kirsty J, Richmond, Alison, Chapman, Stephen K, Walkinshaw, Malcolm D, Munro, Andrew W

“…The first structure of a P450 to an atomic resolution of 1.06 Å has been solved for CYP121 from Mycobacterium tuberculosis . A comparison with P450 EryF…”
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Probing the Ternary Complexes of Indoleamine and Tryptophan 2,3-Dioxygenases by Cryoreduction EPR and ENDOR Spectroscopy by Davydov, Roman M, Chauhan, Nishma, Thackray, Sarah J, Anderson, J. L. Ross, Papadopoulou, Nektaria D, Mowat, Christopher G, Chapman, Stephen K, Raven, Emma L, Hoffman, Brian M

“…We have applied cryoreduction/EPR/ENDOR techniques to characterize the active-site structure of the ferrous-oxy complexes of human (hIDO) and Shewanella…”
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Oxygen activation in neuronal NO synthase: resolving the consecutive mono-oxygenation steps by Papale, Davide, Bruckmann, Chiara, Gazur, Ben, Miles, Caroline S, Mowat, Christopher G, Daff, Simon

“…The vital signalling molecule NO is produced by mammalian NOS (nitric oxide synthase) enzymes in two steps. L-arginine is converted into NOHA…”
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Single-nucleotide polymorphism-based differentiation and drug resistance detection in Mycobacterium tuberculosis from isolates or directly from sputum by Arnold, C., Westland, L., Mowat, G., Underwood, A., Magee, J., Gharbia, S.

“…The rapid technique of pyrosequencing was used to examine 123 samples (in the form of DNA extracts and inactivated sputum) of Mycobacterium spp. Of 99…”
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Antitumour agents as inhibitors of tryptophan 2,3-dioxygenase by Pantouris, Georgios, Mowat, Christopher G.

“…•∼2800 National Cancer Institute USA compounds have been screened as potential inhibitors of TDO and/or IDO.•Seven compounds with anti-tumour properties have…”
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Multi-heme cytochromes--new structures, new chemistry by Mowat, Christopher G, Chapman, Stephen K

“…Heme is one of the most pervasive cofactors in nature and the c-type cytochromes represent one of the largest families of heme-containing proteins. Recent…”
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Towards a new conceptualisation of marginalisation by Mowat, Joan G

“…The OECD report ‘Equity, Excellence and Inclusiveness in Education’ (Schleicher, 2014) highlights the disparities in attainment and opportunity between…”
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