Search Results - "Mowat, A. McI"

Diversity and functions of intestinal mononuclear phagocytes by Joeris, T, Müller-Luda, K, Agace, W W, Mowat, A McI

“…The intestinal lamina propria (LP) contains a diverse array of mononuclear phagocyte (MNP) subsets, including conventional dendritic cells (cDC), monocytes and…”
Get full text

TGFβR signalling controls CD103+CD11b+ dendritic cell development in the intestine by Bain, C. C., Montgomery, J., Scott, C. L., Kel, J. M., Girard-Madoux, M. J. H., Martens, L., Zangerle-Murray, T. F. P., Ober-Blöbaum, J., Lindenbergh-Kortleve, D., Samsom, J. N., Henri, S., Lawrence, T., Saeys, Y., Malissen, B., Dalod, M., Clausen, B. E., Mowat, A. McI

“…CD103 + CD11b + dendritic cells (DCs) are unique to the intestine, but the factors governing their differentiation are unclear. Here we show that transforming…”
Get full text

Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursors by Bain, C C, Scott, C L, Uronen-Hansson, H, Gudjonsson, S, Jansson, O, Grip, O, Guilliams, M, Malissen, B, Agace, W W, Mowat, A McI

“…Macrophages (mφ) are essential for intestinal homeostasis and the pathology of inflammatory bowel disease (IBD), but it is unclear whether discrete mφ…”
Get full text

A role for IL‐4 in immunologically mediated enteropathy by MOWAT, A. MCI, WIDMER, M. B.

“…SUMMARY A number of clinical enteropathies are associated with a local cell‐mediated immune (CMI) response, and experimental evidence indicates that cytokines…”
Get full text

Experimental studies of immunologically mediated enteropathy. V. Destructive enteropathy during an acute graft‐versus‐host reaction in adult BDF1 mice by MOWAT, A. McI, FELSTEIN, M. V.

“…SUMMARY As a means of investigating further the pathogenesis of intestinal immunopathology, we have attempted to produce a destructive enteropathy by inducing…”
Get full text

Prostaglandins and the induction of food sensitive enteropathy by McI MOWAT, A

“…[...]the in vivo role of COX-2 was confirmed by the fact that enteropathy could also be induced in HEL-fed TcR transgenic mice treated with the COX-2 selective…”
Get full text

Preservation of mucosal and systemic adjuvant properties of ISCOMS in the absence of functional interleukin‐4 or interferon‐γ by SMITH, DONACHIE, MCLAREN, MOWAT, A. McI

“…Adjuvants are a critical component of non‐viable vaccine vectors, particularly for those to be used via mucosal routes. Although most adjuvants act by inducing…”
Get full text

Immunological responses to fed protein antigens in mice. I. Reversal of oral tolerance to ovalbumin by cyclophosphamide by Mowat, A M, Strobel, S, Drummond, H E, Ferguson, A

“…Feeding ovalbumin over a wide range of doses is known to reduce subsequent systemic immune responses to parenteral immunization. In the present study, we have…”
Get full text

Enteropathy precedes type 1 diabetes in the BB rat by Graham, S, Courtois, P, Malaisse, W J, Rozing, J, Scott, F W, Mowat, A Mc I

“…Background and aims: There is increasing evidence implicating intestinal immune responses to dietary proteins in the pathogenesis of type 1 autoimmune diabetes…”
Get full text

Experimental studies of immunologically mediated enteropathy. VI. Inhibition of acute intestinal graft-versus-host reaction in mice by 2'-deoxyguanosine by Felstein, M V, Mowat, A M

“…We have attempted to investigate the relative roles of specific cytotoxic T lymphocytes (CTL) and allospecific suppressor T cells (Ts) in the systemic and…”
Get more information

Oral tolerance in disease by GARSIDE, P, MOWAT, A McI, KHORUTS, A

“…Introduction The large surface area of the gastrointestinal tract is covered by a single layer of columnar epithelium which allows efficient absorption of…”
Get full text

Induction of mucosal and systemic immune-responses by immunization with ovalbumin entrapped in poly(lactide-co-glycolide) microparticles by MALOY, K. J, DONACHIE, A. M, O'HAGAN, D. T, MOWAT, A. M

“…We have examined the range of mucosal and systemic immune responses induced by oral or parenteral immunization with ovalbumin (OVA) entrapped in…”
Get full text

Immune-stimulating complexes containing quil A and protein antigen prime class I MHC-restricted T lymphocytes in vivo and are immunogenic by the oral route by MOWAT, A. M, DONACHIE, A. M, REID, G, JARRETT, O

“…Induction of all forms of protective immunity by oral immunization with subunit vaccines is an ideal goal for the development of novel vaccines, but creates…”
Get full text

Nitric oxide mediates intestinal pathology in graft-vs.-host disease by Garside, P, Hutton, A K, Severn, A, Liew, F Y, Mowat, A M

“…We have investigated the involvement of nitric oxide (NO) in intestinal graft-vs.-host reaction (GvHR) in mice. Treatment of mice with L-NG-monomethyl arginine…”
Get more information

Immune stimulating complexes as mucosal vaccines by Smith, Rosemary E, Donachie, Anne M, Mowat, Allan McI

“…There is a need for non‐living adjuvant vectors that will allow a full range of local and systemic immune responses to orally administered purified antigens…”
Get full text

T lymphocyte dependent enteropathy in murine Trichinella spiralis infection by Garside, P, Grencis, R K, Mowat, A M

“…Mice infected with Trichinella spiralis developed significant enteropathy, comprising villus atrophy, crypt hyperplasia, goblet cell hyperplasia and a decrease…”
Get more information

Phenotypic heterogeneity of intraepithelial T lymphocytes from mouse small intestine by MALOY, K. J, MOWAT, A. M, ZAMOYSKA, R, CRISPE, I. N

“…We have used two-colour flow cytometry to examine the heterogeneity of intraepithelial lymphocytes (IEL) from mouse small intestine. We have confirmed the…”
Get full text

Immunohistochemical anlaysis of mucosal gamma-interferon production in coeliac disease by Al-Dawoud, A, Nakshabendi, I, Foulis, A, McI Mowat, A

“…The role of gamma -interferon in the pathogenesis of enteropathies with an immunological basis such as coeliac disease, is unclear. gamma -interferon…”
Get full text

A role for interleukin-1α in immunologically mediated intestinal pathology by MOWAT, A. MCI, HUTTON, A. K, GARSIDE, P, STEEL, M

“…Interleukin-1 (IL-1) is an important mediator of inflammation and has been implicated in several forms of immunopathology. Here we have investigated whether…”
Get full text

The role of antigen recognition and suppressor cells in mice with oral tolerance to ovalbumin by MOWAT, A. M

“…The induction of tolerance by feeding proteins may prevent potentially harmful delayed-type hypersensitivity (DTH) reactions to food antigens. Suppressor T…”
Get full text