Search Results - "Mouz, N"

The crystal structure of the penicillin-binding protein 2x from Streptococcus pneumoniae and its acyl-enzyme form: implication in drug resistance by Gordon, E, Mouz, N, Duée, E, Dideberg, O

“…Penicillin-binding proteins (PBPs), the primary targets for beta-lactam antibiotics, are periplasmic membrane-attached proteins responsible for the…”
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P19-02. High protection of female macaques from repeated intravaginal challenges with SHIV-162P3 upon mucosal vaccination with Gp41 subunits-virosomes by Bomsel, M, Drillet, A, Roger, M, Amacker, M, Mouz, N, Lopalco, L, Devillers, G, Zurbriggen, R, Fleury, S

“…Methods We have developed a mucosal vaccine candidate based on two complementary conserved gp41 subunit antigens- a trimeric recombinant gp41 deleted in known…”
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Identification of a Structural Determinant for Resistance to β -lactam Antibiotics in Gram-Positive Bacteria by Mouz, N., Gordon, E., A.-M. Di Guilmi, Petit, I., Petillot, Y., Dupont, Y., Hakenbeck, R., Vernet, T., Dideberg, O.

“…Streptococcus pneumoniae is the main causal agent of pathologies that are increasingly resistant to antibiotic treatment. Clinical resistance of S. pneumoniae…”
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Liposomal formulation of Gp41 derivate with adjuvant MPLA: vaccine design, immunogenicity in animals and safety in humans by Katinger, D, Wagner, A, Luque, I, Crespillo, S, Conejero-Lara, F, Roger, M, Martin, C, Mouz, N, Mourao, S, Farsang, A, Notka, F, Malcolm, K, Bosquet, N, Le Grand, R, Moog, C, Cope, A, Shattock, R, Lewis, DJ, El Habib, R

“…Doc number: P354…”
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High level production of secreted proteins: Example of the human tissue inhibitor of metalloproteinases 1 by Crombez, L., Marques, B., Lenormand, J.L., Mouz, N., Polack, B., Trocme, C., Toussaint, B.

“…The major difficulty for high-throughput screening of therapeutic protein candidates in experimental animal models of pathologies or for structural studies is…”
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X-ray structure of Streptococcus pneumoniae PBP2x, a primary penicillin target enzyme by Pares, S, Mouz, N, Pétillot, Y, Hakenbeck, R, Dideberg, O

“…All beta-lactam antibiotics exert their biological effects by interacting with a unique class of proteins, the penicillin-binding proteins (PBPs). These…”
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The crystal structure of the penicillin-binding protein 2x from Streptococcus pneumoniae and its acyl-enzyme form: implication in drug resistance 1 1Edited by R. Huber by Gordon, E., Mouz, N., Duée, E., Dideberg, O.

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Immunization with HIV-1 gp41 Subunit Virosomes Induces Mucosal Antibodies Protecting Nonhuman Primates against Vaginal SHIV Challenges by Bomsel, Morgane, Tudor, Daniela, Drillet, Anne-Sophie, Alfsen, Annette, Ganor, Yonatan, Roger, Marie-Gaëlle, Mouz, Nicolas, Amacker, Mario, Chalifour, Anick, Diomede, Lorenzo, Devillier, Gilles, Cong, Zhe, Wei, Qiang, Gao, Hong, Qin, Chuan, Yang, Gui-Bo, Zurbriggen, Rinaldo, Lopalco, Lucia, Fleury, Sylvain

“…Human immunodeficiency virus (HIV)-1 is mainly transmitted mucosally during sexual intercourse. We therefore evaluated the protective efficacy of a vaccine…”
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Use of a Designed Fusion Protein Dissociates Allosteric Properties from the Dodecameric State of Pseudomonas aeruginosa Catabolic Ornithine Carbamoyltransferase by Mouz, Nicolas, Tricot, Catherine, Ebel, Christine, Petillot, Yves, Stalon, Victor, Dideberg, Otto

“…The catabolic ornithine carbamoyltransferase from Pseudomonas aeruginosa, an enzyme consisting of 12 identical 38-kDa subunits, displays allosteric properties,…”
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Crystal structure of PBP2x from a highly penicillin-resistant Streptococcus pneumoniae clinical isolate: a mosaic framework containing 83 mutations by Dessen, A, Mouz, N, Gordon, E, Hopkins, J, Dideberg, O

“…Penicillin-binding proteins (PBPs) are the main targets for beta-lactam antibiotics, such as penicillins and cephalosporins, in a wide range of bacterial…”
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Mutations in the active site of penicillin-binding protein PBP2x from Streptococcus pneumoniae. Role in the specificity for beta-lactam antibiotics by Mouz, N, Di Guilmi, A M, Gordon, E, Hakenbeck, R, Dideberg, O, Vernet, T

“…Penicillin-binding protein 2x (PBP2x) isolated from clinical beta-lactam-resistant strains of Streptococcus pneumoniae (R-PBP2x) have a reduced affinity for…”
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Expression optimization and purification process development of an engineered soluble recombinant mouse linker of activation of T cells using surface enhanced laser desorption/ionization-mass spectrometry by Brenac, Virginie, Mouz, Nicolas, Schapman, Anthony, Ravault, Vincent

“…Protein purification development is the bottleneck of recombinant protein production therefore there is a need to shorten process development and monitoring…”
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The Crystal Structure of the Penicillin-binding Protein 2x from Streptococcus pneumoniae and its Acyl-enzyme Form: Implication in Drug Resistance by Gordon, E, Mouz, N, Duee, E, Dideberg, O

“…Penicillin-binding proteins (PBPs), the primary targets for beta -lactam antibiotics, are periplasmic membrane-attached proteins responsible for the…”
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Identification, Purification, and Characterization of Transpeptidase and Glycosyltransferase Domains of Streptococcus pneumoniae Penicillin-Binding Protein 1a by Di Guilmi, A M, Mouz, N, Andrieu, J P, Hoskins, J, Jaskunas, S R, Gagnon, J, Dideberg, O, Vernet, T

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Deacylation Kinetics Analysis of Streptococcus pneumoniae Penicillin-Binding Protein 2x Mutants Resistant to β-Lactam Antibiotics Using Electrospray Ionization– Mass Spectrometry by Di Guilmi, Anne Marie, Mouz, Nicolas, Pétillot, Yves, Forest, Eric, Dideberg, Otto, Vernet, Thierry

“…Penicillin-binding proteins (PBPs) catalyze the transpeptidase reaction involved in peptidoglycan synthesis and are covalently inhibited by the β-lactam…”
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Glycosyltransferase Domain of Penicillin-Binding Protein 2a from Streptococcus pneumoniae Is Membrane Associated by di Guilmi, A M, Mouz, N, Martin, L, Hoskins, J, Jaskunas, S R, Dideberg, O, Vernet, T

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Increase of the deacylation rate of PBP2x from Streptococcus pneumoniae by single point mutations mimicking the class A β‐lactamases by Chesnel, Laurent, Zapun, André, Mouz, Nicolas, Dideberg, Otto, Vernet, Thierry

“…The class A β‐lactamases and the transpeptidase domain of the penicillin‐binding proteins (PBPs) share the same topology and conserved active‐site residues…”
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