Search Results - "Mouton, Johannes P."

A cross-sectional evaluation of five warfarin anticoagulation services in Uganda and South Africa by Semakula, Jerome Roy, Mouton, Johannes P, Jorgensen, Andrea, Hutchinson, Claire, Allie, Shaazia, Semakula, Lynn, French, Neil, Lamorde, Mohammed, Toh, Cheng-Hock, Blockman, Marc, Sekaggya-Wiltshire, Christine, Waitt, Catriona, Pirmohamed, Munir, Cohen, Karen

“…Warfarin is the most commonly prescribed oral anticoagulant in sub-Saharan Africa and requires ongoing monitoring. The burden of both infectious diseases and…”
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Interrater agreement of two adverse drug reaction causality assessment methods: A randomised comparison of the Liverpool Adverse Drug Reaction Causality Assessment Tool and the World Health Organization-Uppsala Monitoring Centre system by Mouton, Johannes P, Mehta, Ushma, Rossiter, Dawn P, Maartens, Gary, Cohen, Karen

“…A new method to assess causality of suspected adverse drug reactions, the Liverpool Adverse Drug Reaction Causality Assessment Tool (LCAT), showed high…”
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A genome-wide association study of plasma concentrations of warfarin enantiomers and metabolites in sub-Saharan black-African patients by Asiimwe, Innocent G., Blockman, Marc, Cohen, Karen, Cupido, Clint, Hutchinson, Claire, Jacobson, Barry, Lamorde, Mohammed, Morgan, Jennie, Mouton, Johannes P., Nakagaayi, Doreen, Okello, Emmy, Schapkaitz, Elise, Sekaggya-Wiltshire, Christine, Semakula, Jerome R., Waitt, Catriona, Zhang, Eunice J., Jorgensen, Andrea L., Pirmohamed, Munir

“…Diversity in pharmacogenomic studies is poor, especially in relation to the inclusion of black African patients. Lack of funding and difficulties in…”
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Post-traumatic stress disorder as a risk factor for major adverse cardiovascular events: a cohort study of a South African medical insurance scheme by Mesa-Vieira, Cristina, Didden, Christiane, Schomaker, Michael, Mouton, Johannes P., Folb, Naomi, van den Heuvel, Leigh L., Gastaldon, Chiara, Cornell, Morna, Tlali, Mpho, Kassanjee, Reshma, Franco, Oscar H., Seedat, Soraya, Haas, Andreas D.

“…Prior research, largely focused on US male veterans, indicates an increased risk of cardiovascular disease among individuals with post-traumatic stress…”
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Serious adverse drug reactions at two children's hospitals in South Africa by Mouton, Johannes P, Fortuin-de Smidt, Melony C, Jobanputra, Nicole, Mehta, Ushma, Stewart, Annemie, de Waal, Reneé, Technau, Karl-Günter, Argent, Andrew, Kroon, Max, Scott, Christiaan, Cohen, Karen

“…The high HIV prevalence in South Africa may potentially be shaping the local adverse drug reaction (ADR) burden. We aimed to describe the prevalence and…”
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Serious adverse drug reactions in sub‐Saharan Africa in the era of antiretroviral treatment: A systematic review by Mouton, Johannes P., Jobanputra, Nicole, Tatz, Gayle, Cohen, Karen

“…We aimed to summarize and describe the burden of serious adverse drug reactions (ADRs) in sub‐Saharan Africa (SSA) in the era of antiretroviral therapy. We…”
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Stable warfarin dose prediction in sub‐Saharan African patients: A machine‐learning approach and external validation of a clinical dose–initiation algorithm by Asiimwe, Innocent G., Blockman, Marc, Cohen, Karen, Cupido, Clint, Hutchinson, Claire, Jacobson, Barry, Lamorde, Mohammed, Morgan, Jennie, Mouton, Johannes P., Nakagaayi, Doreen, Okello, Emmy, Schapkaitz, Elise, Sekaggya‐Wiltshire, Christine, Semakula, Jerome R., Waitt, Catriona, Zhang, Eunice J., Jorgensen, Andrea L., Pirmohamed, Munir

“…Warfarin remains the most widely prescribed oral anticoagulant in sub‐Saharan Africa. However, because of its narrow therapeutic index, dosing can be…”
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A "Bundle of Care" to Improve Anticoagulation Control in Patients Receiving Warfarin in Uganda and South Africa: Protocol for an Implementation Study by Jorgensen, Andrea L, Orrell, Catherine, Waitt, Catriona, Toh, Cheng-Hock, Sekaggya-Wiltshire, Christine, Hughes, Dyfrig A, Allen, Elizabeth, Okello, Emmy, Tatz, Gayle, Culeddu, Giovanna, Asiimwe, Innocent G, Semakula, Jerome Roy, Mouton, Johannes P, Cohen, Karen, Blockman, Marc, Lamorde, Mohammed, Pirmohamed, Munir

“…The quality of warfarin anticoagulation among Sub-Saharan African patients is suboptimal. This is due to several factors, including a lack of standardized…”
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Adult medical emergency unit presentations due to adverse drug reactions in a setting of high HIV prevalence by Mouton, Johannes P, Jobanputra, Nicole, Njuguna, Christine, Gunter, Hannah, Stewart, Annemie, Mehta, Ushma, Lahri, Sa'ad, Court, Richard, Igumbor, Ehimario, Maartens, Gary, Cohen, Karen

“…South Africa has the world's largest antiretroviral treatment programme, which may contribute to the adverse drug reaction (ADR) burden. We aimed to determine…”
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Anticoagulation in sub‐Saharan Africa: Are direct oral anticoagulants the answer? A review of lessons learnt from warfarin by Semakula, Jerome Roy, Kisa, Geraldine, Mouton, Johannes P., Cohen, Karen, Blockman, Marc, Pirmohamed, Munir, Sekaggya‐Wiltshire, Christine, Waitt, Catriona

“…Warfarin has existed for >7 decades and has been the anticoagulant of choice for many thromboembolic disorders. The recent introduction of direct‐acting oral…”
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Improving anticoagulation in sub‐Saharan Africa: What are the challenges and how can we overcome them? by Mouton, Johannes P., Blockman, Marc, Sekaggya‐Wiltshire, Christine, Semakula, Jerome, Waitt, Catriona, Pirmohamed, Munir, Cohen, Karen

“…Patients in sub‐Saharan Africa generally have poor anticoagulation control. We review the potential reasons for this poor control, as well as the potential…”
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Mortality from adverse drug reactions in adult medical inpatients at four hospitals in South Africa: a cross‐sectional survey by Mouton, Johannes P., Mehta, Ushma, Parrish, Andy G., Wilson, Douglas P. K., Stewart, Annemie, Njuguna, Christine W., Kramer, Nicole, Maartens, Gary, Blockman, Marc, Cohen, Karen

“…Aims Fatal adverse drug reactions (ADRs) are important causes of death, but data from resource‐limited settings are scarce. We determined the proportion of…”
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Key toxicity issues with the WHO-recommended first-line antiretroviral therapy regimen by Mouton, Johannes P, Cohen, Karen, Maartens, Gary

“…WHO recommends tenofovir, efavirenz, and lamivudine or emtricitabine for first-line antiretroviral therapy (ART) in adults, which replaced more toxic regimens…”
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Adverse Drug Reactions Causing Admission to Medical Wards: A Cross-Sectional Survey at 4 Hospitals in South Africa by Mouton, Johannes P., Njuguna, Christine, Kramer, Nicole, Stewart, Annemie, Mehta, Ushma, Blockman, Marc, Fortuin-De Smidt, Melony, De Waal, Reneé, Parrish, Andy G., Wilson, Douglas P.K., Igumbor, Ehimario U., Aynalem, Getahun, Dheda, Mukesh, Maartens, Gary, Cohen, Karen

“…Limited data exist on the burden of serious adverse drug reactions (ADRs) in sub-Saharan Africa, which has high HIV and tuberculosis prevalence. We determined…”
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Developing and Validating a Clinical Warfarin Dose‐Initiation Model for Black‐African Patients in South Africa and Uganda by Asiimwe, Innocent G., Waitt, Catriona, Sekaggya‐Wiltshire, Christine, Hutchinson, Claire, Okello, Emmy, Zhang, Eunice J., Semakula, Jerome R., Mouton, Johannes P., Cohen, Karen, Blockman, Marc, Lamorde, Mohammed, Jorgensen, Andrea L., Pirmohamed, Munir

“…Warfarin remains the oral anticoagulant of choice in sub‐Saharan Africa. However, dosing is challenging due to a highly variable clinical response for a given…”
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The effect of the COVID-19 lockdown on mental health care use in South Africa: an interrupted time-series analysis by Wettstein, Anja, Tlali, Mpho, Joska, John A., Cornell, Morna, Skrivankova, Veronika W., Seedat, Soraya, Mouton, Johannes P., van den Heuvel, Leigh L., Maxwell, Nicola, Davies, Mary-Ann, Maartens, Gary, Egger, Matthias, Haas, Andreas D.

“…The coronavirus disease 2019 (COVID-19) pandemic and ensuing restrictions have negatively affected the mental health and well-being of the general population,…”
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Meta-analysis of genome-wide association studies of stable warfarin dose in patients of African ancestry by Asiimwe, Innocent G., Blockman, Marc, Cavallari, Larisa H., Cohen, Karen, Cupido, Clint, Dandara, Collet, Davis, Brittney H., Jacobson, Barry, Johnson, Julie A., Lamorde, Mohammed, Limdi, Nita A., Morgan, Jennie, Mouton, Johannes P., Muyambo, Sarudzai, Nakagaayi, Doreen, Ndadza, Arinao, Okello, Emmy, Perera, Minoli A., Schapkaitz, Elise, Sekaggya-Wiltshire, Christine, Semakula, Jerome R., Tatz, Gayle, Waitt, Catriona, Yang, Guang, Zhang, Eunice J., Jorgensen, Andrea L., Pirmohamed, Munir

“…•The CYP2C and VKORC1 loci are the most important in determining warfarin dose requirements in individuals of African ancestry.•We identified a biologically…”
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Adverse Drug Reactions Reported to a National HIV & Tuberculosis Health Care Worker Hotline in South Africa: Description and Prospective Follow-Up of Reports by Njuguna, Christine, Stewart, Annemie, Mouton, Johannes P., Blockman, Marc, Maartens, Gary, Swart, Annoesjka, Chisholm, Briony, Jones, Jackie, Dheda, Mukesh, Igumbor, Ehimario U., Cohen, Karen

“…Introduction The National HIV & Tuberculosis Health Care Worker (HCW) Hotline provides advice on the management of suspected adverse drug reactions (ADRs). We…”
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