Search Results - "Moutiez, M"

Dynamic combinatorial assembly of peptide-rhenium coordinates: application to the selection of hCyp-18 inhibitors from a library of 12 x 16 components by Dugave, C, Clavaud, C, Le Gal, J, Thai, R, Moutiez, M

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Dynamic combinatorial assembly of peptide-rhenium coordinates: coordination chemistry for generating new analogs of hCyp-18 ligands by Clavaud, C, Le Gal, J, Thai, R, Moutiez, M, Dugave, C

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On the role of the cis-proline residue in the active site of DsbA by CHARBONNIER, JEAN-BAPTISTE, BELIN, PASCAL, MOUTIEZ, MIREILLE, STURA, ENRICO A., QUÉMÉNEUR, ERIC

“…In addition to the Cys-Xaa-Xaa-Cys motif at position 30–33, DsbA, the essential catalyst for disulfide bond formation in the bacterial periplasm shares with…”
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Purification and characterization of a trypanothione-glutathione thioltransferase from Trypanosoma cruzi by Moutiez, M, Aumercier, M, Schöneck, R, Meziane-Cherif, D, Lucas, V, Aumercier, P, Ouaissi, A, Sergheraert, C, Tartar, A

“…Although trypanothione [T(S)2] is the major thiol component in trypanosomatidae, significant amounts of glutathione are present in Trypanosoma cruzi. This…”
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Slow Folding of Three-Fingered Toxins Is Associated with the Accumulation of Native Disulfide-Bonded Intermediates by Ruoppolo, Margherita, Talamo, Fabio, Pucci, Piero, Moutiez, Mireille, Quèmèneur, Eric, Mènez, Andrè, Marino, Gennaro

“…Snake neurotoxins are short all-β proteins that display a complex organization of the disulfide bonds:  two bonds connect consecutive cysteine residues…”
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On the non-respect of the thermodynamic cycle by DsbA variants by MOUTIEZ, MIREILLE, BUROVA, TATIANA V., HAERTLÉ, THOMAS, QUÉMÉNEUR, ERIC

“…The mechanism of the disulfide-bond forming enzyme DsbA depends on the very low pKa of a cysteine residue in its active-site and on the relative instability of…”
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Reduction of a trisulfide derivative of glutathione by glutathione reductase by Moutiez, M, Aumercier, M, Teissier, E, Parmentier, B, Tartar, A, Sergheraert, C

“…Glutathione trisulfide was synthesized from glutathione disulfide and its reduction by glutathione reductase was studied. A two-step reaction was observed. In…”
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Specificity determinants for the two tRNA substrates of the cyclodipeptide synthase AlbC from Streptomyces noursei by Moutiez, Mireille, Seguin, Jérôme, Fonvielle, Matthieu, Belin, Pascal, Jacques, Isabelle Béatrice, Favry, Emmanuel, Arthur, Michel, Gondry, Muriel

“…Cyclodipeptide synthases (CDPSs) use two aminoacyl-tRNA substrates in a sequential ping-pong mechanism to form a cyclodipeptide. The crystal structures of…”
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2-Amino diphenylsulfides as new inhibitors of trypanothione reductase by Fernandez-Gomez, Rodolfo, Moutiez, Mireille, Aumercier, Marc, Bethegnies, Gilles, Luyckx, Michel, Ouaissi, Ali, Tartar, André, Sergheraert, Christian

“…Trypanothione reductase (TR) is the primary enzyme responsible for the reduction of trypanothione, the analog of glutathione found in trypanosomatidae. We have…”
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A microplate assay for trypanothione reductase inhibitors by Aumercier, M, Meziane-Cherif, D, Moutiez, M, Tartar, A, Sergheraert, C

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Synthesis and Evaluation of Glyψ(PO2R-N)Pro-Containing Pseudopeptides as Novel Inhibitors of the Human Cyclophilin hCyp-18 by Demange, Luc, Moutiez, Mireille, Dugave, Christophe

“…The human cyclophilin hCyp-18, an abundant peptidyl-prolyl cis−trans isomerase (PPIase) implicated in protein folding, controls the infection of CD4+ T-cells…”
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A Tandem of SH3-like Domains Participates in RNA Binding in KIN17, a Human Protein Activated in Response to Genotoxics by le Maire, Albane, Schiltz, Marc, Stura, Enrico A., Pinon-Lataillade, Ghislaine, Couprie, Joël, Moutiez, Mireille, Gondry, Muriel, Angulo, Jaime F., Zinn-Justin, Sophie

“…The human KIN17 protein is an essential nuclear protein conserved from yeast to human and expressed ubiquitously in mammals. Suppression of Rts2, the yeast…”
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Analysis of the metal-binding selectivity of the metallochaperone CopZ from Enterococcus hirae by electrospray ionization mass spectrometry by Urvoas, Agathe, Amekraz, Badia, Moulin, Christophe, Le Clainche, Loïc, Stöcklin, Reto, Moutiez, Mireille

“…Metallochaperones are soluble proteins involved in metal transport and regulation in vivo. Copper metallochaperones belong to a structural family of metal…”
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Dual Expression System Suitable for High-Throughput Fluorescence-Based Screening and Production of Soluble Proteins by Braud, Sandrine, Moutiez, Mireille, Belin, Pascal, Abello, Nicolas, Drevet, Pascal, Zinn-Justin, Sophie, Courçon, Marie, Masson, Cédric, Dassa, Janie, Charbonnier, Jean-Baptiste, Boulain, Jean-Claude, Ménez, André, Genet, Roger, Gondry, Muriel

“…Many studies that aim to characterize the proteome structurally or functionally require the production of pure protein in a high-throughput format. We have…”
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Interaction of human cyclophilin hCyp-18 with short peptides suggests the existence of two functionally independent subsites by Demange, Luc, Moutiez, Mireille, Vaudry, Karine, Dugave, Christophe

“…The binding of peptides, derived from the model substrate Suc-Ala-Ala-Pro-Phe-pNA, to the human cyclophilin hCyp-18 was investigated. HCyp-18 is able to bind…”
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Engineering cyclophilin into a proline-specific endopeptidase by Quéméneur, Eric, Moutiez, Mireille, Charbonnier, Jean-Baptiste, Ménez, Andr

“…Designing an enzyme requires, among a number of parameters, the appropriate positioning of catalytic machinery within a substrate-binding cleft. Using the…”
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Description of the topographical changes associated to the different stages of the DsbA catalytic cycle by Vinci, Floriana, Couprie, Joël, Pucci, Piero, Quéméneur, Eric, Moutiez, Mireille

“…This paper provides a description of the surface topography of DsbA, the bacterial disulfide‐bond forming enzyme, in the different phases of its catalytic…”
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Investigation of the DsbA Mechanism through the Synthesis and Analysis of an Irreversible Enzyme−Ligand Complex by Couprie, Joël, Vinci, Floriana, Dugave, Christophe, Quéméneur, Eric, Moutiez, Mireille

“…Approaching the molecular mechanism of some enzymes is hindered by the difficulty of obtaining suitable protein−ligand complexes for structural…”
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Design of a Gag Pentapeptide Analogue that Binds Human Cyclophilin A More Efficiently than the Entire Capsid Protein:  New Insights for the Development of Novel Anti-HIV-1 Drugs by Li, Quan, Moutiez, Mireille, Charbonnier, Jean-Baptiste, Vaudry, Karine, Ménez, André, Quéméneur, Eric, Dugave, Christophe

“…Cyclophilin A (hCyp-18), a ubiquitous cytoplasmic peptidyl-prolyl cis/trans isomerase (PPIase), orchestrates HIV-1 core packaging. hCyp-18, incorporated into…”
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Metal‐binding stoichiometry and selectivity of the copper chaperone CopZ from Enterococcus hirae by Urvoas, Agathe, Moutiez, Mireille, Estienne, Clément, Couprie, Joël, Mintz, Elisabeth, Le Clainche, Loïc

“…We studied the interaction of several metal ions with the copper chaperone from Enterococcus hirae (EhCopZ). We show that the stoichiometry of the…”
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