Search Results - "Mout, Rubul"

Surface functionalization of nanoparticles for nanomedicine by Mout, Rubul, Moyano, Daniel F, Rana, Subinoy, Rotello, Vincent M

“…Control of interactions between nanoparticles and biosystems is essential for the effective utilization of these materials in biomedicine. A wide variety of…”
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Monolayer coated gold nanoparticles for delivery applications by Rana, Subinoy, Bajaj, Avinash, Mout, Rubul, Rotello, Vincent M.

“…Gold nanoparticles (AuNPs) provide attractive vehicles for delivery of drugs, genetic materials, proteins, and small molecules. AuNPs feature low core toxicity…”
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Direct Cytosolic Delivery of CRISPR/Cas9-Ribonucleoprotein for Efficient Gene Editing by Mout, Rubul, Ray, Moumita, Yesilbag Tonga, Gulen, Lee, Yi-Wei, Tay, Tristan, Sasaki, Kanae, Rotello, Vincent M

“…Genome editing through the delivery of CRISPR/Cas9-ribonucleoprotein (Cas9-RNP) reduces unwanted gene targeting and avoids integrational mutagenesis that can…”
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In Vivo Delivery of CRISPR/Cas9 for Therapeutic Gene Editing: Progress and Challenges by Mout, Rubul, Ray, Moumita, Lee, Yi-Wei, Scaletti, Federica, Rotello, Vincent M

“…The successful use of clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9-based gene editing for therapeutics requires efficient in vivo…”
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Regulation of Macrophage Recognition through the Interplay of Nanoparticle Surface Functionality and Protein Corona by Saha, Krishnendu, Rahimi, Mehran, Yazdani, Mahdieh, Kim, Sung Tae, Moyano, Daniel F, Hou, Singyuk, Das, Ridhha, Mout, Rubul, Rezaee, Farhad, Mahmoudi, Morteza, Rotello, Vincent M

“…Using a family of cationic gold nanoparticles (NPs) with similar size and charge, we demonstrate that proper surface engineering can control the nature and…”
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Supramolecular regulation of bioorthogonal catalysis in cells using nanoparticle-embedded transition metal catalysts by Tonga, Gulen Yesilbag, Jeong, Youngdo, Duncan, Bradley, Mizuhara, Tsukasa, Mout, Rubul, Das, Riddha, Kim, Sung Tae, Yeh, Yi-Cheun, Yan, Bo, Hou, Singyuk, Rotello, Vincent M.

“…Bioorthogonal catalysis broadens the functional possibilities of intracellular chemistry. Effective delivery and regulation of synthetic catalytic systems in…”
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General Strategy for Direct Cytosolic Protein Delivery via Protein–Nanoparticle Co‑engineering by Mout, Rubul, Ray, Moumita, Tay, Tristan, Sasaki, Kanae, Yesilbag Tonga, Gulen, Rotello, Vincent M

“…Endosomal entrapment is a key hurdle for most intracellular protein-based therapeutic strategies. We report a general strategy for efficient delivery of…”
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Design of multi-scale protein complexes by hierarchical building block fusion by Hsia, Yang, Mout, Rubul, Sheffler, William, Edman, Natasha I., Vulovic, Ivan, Park, Young-Jun, Redler, Rachel L., Bick, Matthew J., Bera, Asim K., Courbet, Alexis, Kang, Alex, Brunette, T. J., Nattermann, Una, Tsai, Evelyn, Saleem, Ayesha, Chow, Cameron M., Ekiert, Damian, Bhabha, Gira, Veesler, David, Baker, David

“…A systematic and robust approach to generating complex protein nanomaterials would have broad utility. We develop a hierarchical approach to designing…”
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CRISPRed Macrophages for Cell-Based Cancer Immunotherapy by Ray, Moumita, Lee, Yi-Wei, Hardie, Joseph, Mout, Rubul, Yeşilbag Tonga, Gulen, Farkas, Michelle E, Rotello, Vincent M

“…We present here an integrated nanotechnology/biology strategy for cancer immunotherapy that uses arginine nanoparticles (ArgNPs) to deliver CRISPR-Cas9 gene…”
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Programmed Self-Assembly of Hierarchical Nanostructures through Protein–Nanoparticle Coengineering by Mout, Rubul, Yesilbag Tonga, Gulen, Wang, Li-Sheng, Ray, Moumita, Roy, Trinava, Rotello, Vincent M

“…Hierarchical organization of macromolecules through self-assembly is a prominent feature in biological systems. Synthetic fabrication of such structures…”
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Ratiometric Array of Conjugated Polymers–Fluorescent Protein Provides a Robust Mammalian Cell Sensor by Rana, Subinoy, Elci, S. Gokhan, Mout, Rubul, Singla, Arvind K, Yazdani, Mahdieh, Bender, Markus, Bajaj, Avinash, Saha, Krishnendu, Bunz, Uwe H. F, Jirik, Frank R, Rotello, Vincent M

“…Supramolecular complexes of a family of positively charged conjugated polymers (CPs) and green fluorescent protein (GFP) create a fluorescence resonance energy…”
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Cancer Cell Discrimination Using Host–Guest “Doubled” Arrays by Le, Ngoc D. B, Yesilbag Tonga, Gulen, Mout, Rubul, Kim, Sung-Tae, Wille, Marcos E, Rana, Subinoy, Dunphy, Karen A, Jerry, D. Joseph, Yazdani, Mahdieh, Ramanathan, Rajesh, Rotello, Caren M, Rotello, Vincent M

“…We report a nanosensor that uses cell lysates to rapidly profile the tumorigenicity of cancer cells. This sensing platform uses host–guest interactions between…”
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Direct Delivery of Functional Proteins and Enzymes to the Cytosol Using Nanoparticle-Stabilized Nanocapsules by Tang, Rui, Kim, Chang Soo, Solfiell, David J, Rana, Subinoy, Mout, Rubul, Velázquez-Delgado, Elih M, Chompoosor, Apiwat, Jeong, Youngdo, Yan, Bo, Zhu, Zheng-Jiang, Kim, Chaekyu, Hardy, Jeanne A, Rotello, Vincent M

“…Intracellular protein delivery is an important tool for both therapeutic and fundamental applications. Effective protein delivery faces two major challenges:…”
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Rapid Identification of Bacterial Biofilms and Biofilm Wound Models Using a Multichannel Nanosensor by Li, Xiaoning, Kong, Hao, Mout, Rubul, Saha, Krishnendu, Moyano, Daniel F, Robinson, Sandra M, Rana, Subinoy, Zhang, Xinrong, Riley, Margaret A, Rotello, Vincent M

“…Identification of infectious bacteria responsible for biofilm-associated infections is challenging due to the complex and heterogeneous biofilm matrix. To…”
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Co-Delivery of Protein and Small Molecule Therapeutics Using Nanoparticle-Stabilized Nanocapsules by Kim, Chang Soo, Mout, Rubul, Zhao, Yunlong, Yeh, Yi-Cheun, Tang, Rui, Jeong, Youngdo, Duncan, Bradley, Hardy, Jeanne A., Rotello, Vincent M.

“…Combination therapy employing proteins and small molecules provides access to synergistic treatment strategies. Co-delivery of these two payloads is…”
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Array-Based Sensing of Metastatic Cells and Tissues Using Nanoparticle–Fluorescent Protein Conjugates by Rana, Subinoy, Singla, Arvind K, Bajaj, Avinash, Elci, S. Gokhan, Miranda, Oscar R, Mout, Rubul, Yan, Bo, Jirik, Frank R, Rotello, Vincent M

“…Rapid and sensitive methods of discriminating between healthy tissue and metastases are critical for predicting disease course and designing therapeutic…”
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Rapid phenotyping of cancer stem cells using multichannel nanosensor arrays by Geng, Yingying, Goel, Hira L., Le, Ngoc B., Yoshii, Tatsuyuki, Mout, Rubul, Tonga, Gulen Y., Amante, John J., Mercurio, Arthur M., Rotello, Vincent M.

“…Cancer stem cells (CSCs) contribute to multidrug resistance, tumor recurrence and metastasis, making them prime therapeutic targets. Their ability to…”
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Cytosolic and Nuclear Delivery of CRISPR/Cas9-ribonucleoprotein for Gene Editing Using Arginine Functionalized Gold Nanoparticles by Mout, Rubul, Rotello, Vincent M

“…In this protocol, engineered Cas9-ribonucleoprotein (Cas9 protein and sgRNA, together called Cas9-RNP) and gold nanoparticles are used to make nanoassemblies…”
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A General Method for Intracellular Protein Delivery through 'E-tag' Protein Engineering and Arginine Functionalized Gold Nanoparticles by Mout, Rubul, Rotello, Vincent M

“…In this protocol, we describe a method for direct cytosolic protein delivery that avoids endosomal entrapment of the delivered proteins. We achieved this by…”
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A Multichannel Biosensor for Rapid Determination of Cell Surface Glycomic Signatures by Rana, Subinoy, Le, Ngoc D. B, Mout, Rubul, Duncan, Bradley, Elci, S. Gokhan, Saha, Krishnendu, Rotello, Vincent M

“…Cell surface glycosylation serves a fundamental role in dictating cell and tissue behavior. Cell surface glycomes differ significantly, presenting viable…”
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