Search Results - "Mousley, Carl J."

The Sec14 superfamily and mechanisms for crosstalk between lipid metabolism and lipid signaling by Bankaitis, Vytas A., Mousley, Carl J., Schaaf, Gabriel

“…Lipid signaling pathways define central mechanisms for cellular regulation. Productive lipid signaling requires an orchestrated coupling between lipid…”
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Cancer associated mutations in Sec61γ alter the permeability of the ER translocase by Witham, Christopher M, Paxman, Aleshanee L, Baklous, Lamprini, Steuart, Robert F L, Schulz, Benjamin L, Mousley, Carl J

“…Translocation of secretory and integral membrane proteins across or into the ER membrane occurs via the Sec61 complex, a heterotrimeric protein complex…”
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Diverse Sphingolipid Species Harbor Different Effects on Ire1 Clustering by Bieniawski, Mark A., Stevens, Kofi L. P., Witham, Christopher M., Steuart, Robert F. L., Bankaitis, Vytas A., Mousley, Carl J.

“…Endoplasmic reticulum (ER) function is dedicated to multiple essential processes in eukaryotes, including the processing of secretory proteins and the…”
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A Sterol-Binding Protein Integrates Endosomal Lipid Metabolism with TOR Signaling and Nitrogen Sensing by Mousley, Carl J., Yuan, Peihua, Gaur, Naseem A., Trettin, Kyle D., Nile, Aaron H., Deminoff, Stephen J., Dewar, Brian J., Wolpert, Max, Macdonald, Jeffrey M., Herman, Paul K., Hinnebusch, Alan G., Bankaitis, Vytas A.

“…Kes1, and other oxysterol-binding protein superfamily members, are involved in membrane and lipid trafficking through trans-Golgi network (TGN) and endosomal…”
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Functional Anatomy of Phospholipid Binding and Regulation of Phosphoinositide Homeostasis by Proteins of the Sec14 Superfamily by Schaaf, Gabriel, Ortlund, Eric A., Tyeryar, Kimberly R., Mousley, Carl J., Ile, Kristina E., Garrett, Teresa A., Ren, Jihui, Woolls, Melissa J., Raetz, Christian R.H., Redinbo, Matthew R., Bankaitis, Vytas A.

“…Sec14, the major yeast phosphatidylinositol (PtdIns)/phosphatidylcholine (PtdCho) transfer protein, regulates essential interfaces between lipid metabolism and…”
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Local control of phosphatidylinositol 4-phosphate signaling in the Golgi apparatus by Vps74 and Sac1 phosphoinositide phosphatase by Wood, Christopher S, Hung, Chia-Sui, Huoh, Yu-San, Mousley, Carl J, Stefan, Christopher J, Bankaitis, Vytas, Ferguson, Kathryn M, Burd, Christopher G

“…In the Golgi apparatus, lipid homeostasis pathways are coordinated with the biogenesis of cargo transport vesicles by phosphatidylinositol 4-kinases (PI4Ks)…”
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Golgi Membrane Dynamics and Lipid Metabolism by Bankaitis, Vytas A., Garcia-Mata, Rafael, Mousley, Carl J.

“…The striking morphology of the Golgi complex has fascinated cell biologists since its discovery over 100 years ago. Yet, despite intense efforts to understand…”
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The Sec14-superfamily and the regulatory interface between phospholipid metabolism and membrane trafficking by Mousley, Carl J., Tyeryar, Kimberly R., Vincent-Pope, Patrick, Bankaitis, Vytas A.

“…A central principle of signal transduction is the appropriate control of the process so that relevant signals can be detected with fine spatial and temporal…”
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The oxysterol-binding protein superfamily: new concepts and old proteins by Villasmil, Michelle L, Bankaitis, Vytas A, Mousley, Carl J

“…The Kes1 OSBP (oxysterol-binding protein) is a key regulator of membrane trafficking through the TGN (trans-Golgi network) and endosomal membranes. We…”
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Resurrection of a functional phosphatidylinositol transfer protein from a pseudo-Sec14 scaffold by directed evolution by Schaaf, Gabriel, Dynowski, Marek, Mousley, Carl J, Shah, Sweety D, Yuan, Peihua, Winklbauer, Eva M, de Campos, Marília K F, Trettin, Kyle, Quinones, Mary-Chely, Smirnova, Tatyana I, Yanagisawa, Lora L, Ortlund, Eric A, Bankaitis, Vytas A

“…Sec14-superfamily proteins integrate the lipid metabolome with phosphoinositide synthesis and signaling via primed presentation of phosphatidylinositol…”
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An equal opportunity collaboration between lipid metabolism and proteins in the control of membrane trafficking in the trans-Golgi and endosomal systems by Wang, Yaxi, Mousley, Carl J, Lete, Marta G, Bankaitis, Vytas A

“…Recent years have witnessed the evolution of the cell biology of lipids into an extremely active area of investigation. Deciphering the involvement of lipid…”
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A Lipid Transfer Protein Signaling Axis Exerts Dual Control of Cell-Cycle and Membrane Trafficking Systems by Huang, Jin, Mousley, Carl J., Dacquay, Louis, Maitra, Nairita, Drin, Guillaume, He, Chong, Ridgway, Neale D., Tripathi, Ashutosh, Kennedy, Michael, Kennedy, Brian K., Liu, Wenshe, Baetz, Kristin, Polymenis, Michael, Bankaitis, Vytas A.

“…Kes1/Osh4 is a member of the conserved, but functionally enigmatic, oxysterol binding protein-related protein (ORP) superfamily that inhibits…”
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Functional diversification of the chemical landscapes of yeast Sec14-like phosphatidylinositol transfer protein lipid-binding cavities by Tripathi, Ashutosh, Martinez, Elliott, Obaidullah, Ahmad J., Lete, Marta G., Lönnfors, Max, Khan, Danish, Soni, Krishnakant G., Mousley, Carl J., Kellogg, Glen E., Bankaitis, Vytas A.

“…Phosphatidylinositol-transfer proteins (PITPs) are key regulators of lipid signaling in eukaryotic cells. These proteins both potentiate the activities of…”
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Lipid transfer proteins and the tuning of compartmental identity in the Golgi apparatus by McDermott, Mark I., Mousley, Carl J.

“…•Lipid composition is a key determinant of compartmentalization throughout the secretory pathway.•PITPs potentiate phosphoinositide metabolism to promote…”
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A phosphatidylinositol transfer protein integrates phosphoinositide signaling with lipid droplet metabolism to regulate a developmental program of nutrient stress-induced membrane biogenesis by Ren, Jihui, Pei-Chen Lin, Coney, Pathak, Manish C, Temple, Brenda R S, Nile, Aaron H, Mousley, Carl J, Duncan, Mara C, Eckert, Debra M, Leiker, Thomas J, Ivanova, Pavlina T, Myers, David S, Murphy, Robert C, Brown, H Alex, Verdaasdonk, Jolien, Bloom, Kerry S, Ortlund, Eric A, Neiman, Aaron M, Bankaitis, Vytas A

“…Lipid droplet (LD) utilization is an important cellular activity that regulates energy balance and release of lipid second messengers. Because fatty acids…”
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Dissecting the role of histidine kinase and HOG1 mitogen-activated protein kinase signalling in stress tolerance and pathogenicity of Parastagonospora nodorum on wheat by John, Evan, Lopez-Ruiz, Francisco, Rybak, Kasia, Mousley, Carl J, Oliver, Richard P, Tan, Kar-Chun

“…The HOG1 mitogen-activated protein kinase (MAPK) pathway is activated through two-component histidine kinase (HK) signalling. This pathway was first…”
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Correction: Functional diversification of the chemical landscapes of yeast Sec14-like phosphatidylinositol transfer protein lipid-binding cavities by Tripathi, Ashutosh, Martinez, Elliott, Obaidullah, Ahmad J., Lete, Marta G., Lönnfors, Max, Khan, Danish, Soni, Krishnakant G., Mousley, Carl J., Kellogg, Glen E., Bankaitis, Vytas A.

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Correction: Functional diversification of the chemical landscapes of yeast Sec14-like phosphatidylinositol transfer protein lipid-binding cavities by Tripathi, Ashutosh, Martinez, Elliott, Obaidullah, Ahmad J., Lete, Marta G., Lönnfors, Max, Khan, Danish, Soni, Krishnakant G., Mousley, Carl J., Kellogg, Glen E., Bankaitis, Vytas A.

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The conserved C-terminus of Sss1p is required to maintain the endoplasmic reticulum permeability barrier by Witham, Christopher M., Dassanayake, Hasindu G., Paxman, Aleshanee L., Stevens, Kofi L.P., Baklous, Lamprini, White, Paris F., Black, Amy L., Steuart, Robert F.L., Stirling, Colin J., Schulz, Benjamin L., Mousley, Carl J.

“…The endoplasmic reticulum (ER) is the entry point to the secretory pathway and major site of protein biogenesis. Translocation of secretory and integral…”
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WITHDRAWN: The Fundamental And Pathological Importance Of Oxysterol Binding Protein And Its Related Proteins by Dye, Danielle E, Bieniawski, Mark A, Wright, Sarah C E, McCauley, Angela, Coombe, Deirdre R, Mousley, Carl J

“…This article has been withdrawn by the authors as part of this review overlapped with the contents of Pietrangelo A and Ridgway ND. 2018. Cellular and…”
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