Search Results - "Mousavizadeh, Rouhollah"
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β1 integrin, ILK and mTOR regulate collagen synthesis in mechanically loaded tendon cells
Published in Scientific reports (28-07-2020)“…Tendons are specialized tissues composed primarily of load-responsive fibroblasts (tenocytes) embedded in a collagen-rich extracellular matrix. Habitual…”
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2
MRGPRX2-mediated mast cell activation by substance P from overloaded human tenocytes induces inflammatory and degenerative responses in tendons
Published in Scientific reports (12-06-2024)“…Mast cells are immune cells minimally present in normal tendon tissue. The increased abundance of mast cells in tendinopathy biopsies and at the sites of…”
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3
Exposure to oxLDL impairs TGF-β activity in human tendon cells
Published in BMC musculoskeletal disorders (16-03-2023)“…Previous studies have shown that patients with hypercholesterolemia experience elevated levels of oxidized LDL (oxLDL), a molecule which triggers inflammation…”
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4
The application of mechanical load onto mouse tendons by magnetic restraining represses Mmp-3 expression
Published in BMC research notes (30-06-2023)“…Mechanical loading is crucial for tendon matrix homeostasis. Under-stimulation of tendon tissue promotes matrix degradation and ultimately tendon failure. In…”
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5
Mild hypercholesterolemia impacts achilles sub-tendon mechanical properties in young rats
Published in BMC musculoskeletal disorders (12-04-2023)“…Hypercholesterolemia is associated with tendon pathology, but the reasons underpinning this relationship are not well understood. Cholesterol can accumulate in…”
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6
Cyclic strain alters the expression and release of angiogenic factors by human tendon cells
Published in PloS one (13-05-2014)“…Angiogenesis is associated with the tissue changes underlying chronic overuse tendinopathy. We hypothesized that repetitive, cyclic loading of human tendon…”
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7
The Impact of Hypercholesterolemia on Tendon Injury Repair
Published in The FASEB journal (01-05-2021)“…Background Hypercholesterolemia is a condition characterized by high blood cholesterol levels and is associated with tendon xanthomas (cholesterol deposits…”
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8
In vitro collagen biomarkers in mechanically stimulated human tendon cells: a systematic review
Published in Connective tissue research (03-03-2024)“…The aim of this study was to comprehensively examine and summarize the available in vitro evidence regarding the relationship between mechanical stimulation…”
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9
Exposure to oxLDL impairs TGF-[beta] activity in human tendon cells
Published in BMC musculoskeletal disorders (16-03-2023)“…Background Previous studies have shown that patients with hypercholesterolemia experience elevated levels of oxidized LDL (oxLDL), a molecule which triggers…”
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10
Mast cells exert pro-inflammatory effects of relevance to the pathophyisology of tendinopathy
Published in Arthritis research & therapy (01-01-2013)“…We have previously found an increased mast cell density in tendon biopsies from patients with patellar tendinopathy compared to controls. This study examined…”
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11
The impact of mild hypercholesterolemia on injury repair in the rat patellar tendon
Published in Journal of orthopaedic research (01-09-2023)“…Hypercholesterolemia is associated with tendon pathology and injury prevalence. Lipids can accumulate in the tendon's extracellular spaces, which may disrupt…”
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12
The tourniquet's effects on skeletal muscle during total knee arthroplasty
Published in Journal of orthopaedic research (01-09-2024)“…This study investigates the impact of perioperative tourniquet on skeletal muscle cells during total knee arthroplasty (TKA) and its effects on the gene…”
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13
Influence of repetitive mechanical loading on MMP2 activity in tendon fibroblasts
Published in Journal of orthopaedic research (01-11-2016)“…ABSTRACT Matrix metalloproteinase2 has been implicated in tendon pathology caused by repetitive movements. However, its activity in the early stages of the…”
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14
Angiopoietin-like 4 Enhances the Proliferation and Migration of Tendon Fibroblasts
Published in Medicine and science in sports and exercise (01-09-2017)“…PURPOSEAngiopoietin-like 4 (ANGPTL4) is known to play a variety of roles in the response to exercise, and more recently has been shown to enhance the healing…”
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15
Angiopoietin‐like 4 promotes angiogenesis in the tendon and is increased in cyclically loaded tendon fibroblasts
Published in The Journal of physiology (01-06-2016)“…Key points Angiopoietin‐like 4 (ANGPTL4) modulates tendon neovascularization. Cyclic loading stimulates the activity of transforming growth factor‐β and…”
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16
Abstract B013: STEAP1 facilitates iron transport in ewing sarcoma to support mitochondrial activity
Published in Clinical cancer research (15-09-2022)“…Abstract Ewing sarcoma (EwS) is a highly aggressive bone-associated tumor of children and young adults with strong propensity to progress and dismal outcome…”
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17
Effect of Spiritual Care Program on Quality of Life in Patients with Heart Failure
Published in Evidence based care : quarterly journal of Mashhad School of Nursing and Midwifery (01-07-2021)“…Background: Heart failure (HF) is the common result of most heart disorders. The quality of life (QoL) of these patients is severely impaired and they need…”
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18
Dexamethasone decreases substance P expression in human tendon cells: an in vitro study
Published in Rheumatology (Oxford, England) (01-02-2015)“…Glucocorticoid injections are used by rheumatologists to treat chronic tendinopathy. Surprisingly, the mechanisms by which corticosteroids induce pain relief…”
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Mechanism of mast cell adhesion to human tenocytes in vitro
Published in Journal of orthopaedic research (01-01-2015)“…ABSTRACT Mast cells and fibroblasts are two key players involved in many fibrotic and degenerative disorders. In the present study we examined the nature of…”
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Evaluation of the effect of mechanical loading on angiogenic factors in tendinopathy
Published in Journal of bodywork and movement therapies (01-10-2012)Get full text
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