Search Results - "Mousa, Mai H.A."

Lead Optimization of BIBR1591 To Improve Its Telomerase Inhibitory Activity: Design and Synthesis of Novel Four Chemical Series with In Silico, In Vitro, and In Vivo Preclinical Assessments by Al-Karmalawy, Ahmed A., Mousa, Mai H. A., Sharaky, Marwa, Mourad, Mai A. E., El-Dessouki, Ahmed M., Hamouda, Amir O., Alnajjar, Radwan, Ayed, Abdelmoneim A., Shaldam, Moataz A., Tawfik, Haytham O.

“…Herein, modifications to the previously reported BIBR1591 were conducted to obtain bioisosteric candidates with improved activities. The % inhibition of the…”
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Novel quinazolinone Derivatives: Design, synthesis and in vivo evaluation as potential agents targeting Alzheimer disease by Moftah, Hadeer K., Mousa, Mai H.A., Elrazaz, Eman Z., Kamel, Ahmed S., Lasheen, Deena S., Georgey, Hanan H.

“…[Display omitted] •A series of quinazolinone derivatives were synthesized and tested preliminarily for their in vitro AChE inhibitory activity.•Compounds 4b,…”
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Rationale design of novel substituted 1,3,5-triazine candidates as dual IDH1(R132H)/ IDH2(R140Q) inhibitors with high selectivity against acute myeloid leukemia: In vitro and in vivo preclinical investigations by Tawfik, Haytham O., Mousa, Mai H.A., Zaky, Mohamed Y., El-Dessouki, Ahmed M., Sharaky, Marwa, Abdullah, Omeima, El-Hamamsy, Mervat H., Al-Karmalawy, Ahmed A.

“…[Display omitted] •1,3,5-Triazine candidates were designed as dual IDH1/IDH2 inhibitors.•A panel of 60 human cancer cell lines assessed by the NCI was…”
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Muti-target rationale design of novel substituted N-phenyl-2-((6-phenylpyridazin-3-yl)thio)acetamide candidates as telomerase/JAK1/STAT3/TLR4 inhibitors: In vitro and in vivo investigations by Shaldam, Moataz A., Mousa, Mai H.A., Tawfik, Haytham O., El-Dessouki, Ahmed M., Sharaky, Marwa, Saleh, Mohamed M., Alzahrani, Abdullah Yahya Abdullah, Moussa, Sana Ben, Al-Karmalawy, Ahmed A.

“…[Display omitted] •The new candidate 4l with improved telomerase and growth inhibition suggesting its potential use as a successful “multitarget-directed…”
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Design and Synthesis of Novel Symmetric Fluorene-2,7-Diamine Derivatives as Potent Hepatitis C Virus Inhibitors by Mousa, Mai H A, Ahmed, Nermin S, Schwedtmann, Kai, Frakolaki, Efseveia, Vassilaki, Niki, Zoidis, Grigoris, Weigand, Jan J, Abadi, Ashraf H

“…Hepatitis C virus (HCV) is an international challenge. Since the discovery of NS5A direct-acting antivirals, researchers turned their attention to pursue novel…”
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Symmetric Anti-HCV Agents: Synthesis, Antiviral Properties, and Conformational Aspects of Core Scaffolds by Leila, Alaa R. S, Mousa, Mai H. A, Frakolaki, Efseveia, Vassilaki, Niki, Bartenschlager, Ralf, Zoidis, Grigoris, Abdel-Halim, Mohammad, Abadi, Ashraf H

“…As hepatitis C virus (HCV) is one of the major health problems in many countries, interest has been aroused in the design, synthesis, and optimization of novel…”
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