Search Results - "Mourad, P. D."

Transcranial focused ultrasound, pulsed at 40 Hz, activates microglia acutely and reduces Aβ load chronically, as demonstrated in vivo by Bobola, M.S., Chen, L., Ezeokeke, C.K., Olmstead, T.A., Nguyen, C., Sahota, A., Williams, R.G., Mourad, P.D.

“…Iaccarino et al. (2016) [1] exposed 1 h of light flickering at 40 Hz to awake 5XFAD Alzheimer’s Disease (AD) mouse models, generating action potentials at…”
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A Pre-clinical Study of the Response Threshold of Intact and Transected Nerves to Stimulation by Transcutaneous Intense Focused Ultrasound by Bobola, MS, Ezeokeke, CK, Kuznetslova, K, Lahti, AC, Loeser, JD, Olmstead, TA, Friedly, JL, Mourad, PD

“…We used diagnostic ultrasound imaging to guide individual bursts (0.1 s) of 2 MHz intense focused ultrasound (iFU) to determine the sensitivity of intact and…”
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Transcranial and pulsed focused ultrasound that activates brain can accelerate remyelination in a mouse model of multiple sclerosis by Olmstead, T A, Chiarelli, P A, Griggs, D J, McClintic, A M, Myroniv, A N, Mourad, P D

“…Multiple sclerosis (MS) impacts approximately 400,000 in the United States and is the leading cause of disability among young to middle aged people in the…”
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Cerebral aneurysms treated with flow-diverting stents: computational models with intravascular blood flow measurements by Levitt, M R, McGah, P M, Aliseda, A, Mourad, P D, Nerva, J D, Vaidya, S S, Morton, R P, Ghodke, B V, Kim, L J

“…Computational fluid dynamics modeling is useful in the study of the hemodynamic environment of cerebral aneurysms, but patient-specific measurements of…”
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Measured changes in ocean surface roughness due to atmospheric boundary layer rolls by Vandemark, D., Mourad, P. D., Bailey, S. A., Crawford, T. L., Vogel, C. A., Sun, J., Chapron, B.

“…A research aircraft was recently flown over the Mid‐Atlantic Bight during a mild cold air outbreak to sample the planetary boundary layer at low levels of…”
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Case study of an amputee regaining sensation and muscle function in a residual limb after peripheral nerve stimulation by intense focused ultrasound by Ezeokeke, C.K., Bobola, M.S., Selby, M., Ko, J.H., Friedly, J.L., Mourad, P.D.

“…•Intense focused ultrasound activated a once dormant peripheral nerve in an amputee’s residual limb.•This activation occurred within moments of application of…”
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Effect of high-intensity focused ultrasound on whole blood with and without microbubble contrast agent by Poliachik, S L, Chandler, W L, Mourad, P D, Bailey, M R, Bloch, S, Cleveland, R O, Kaczkowski, P, Keilman, G, Porter, T, Crum, L A

“…Using human whole blood samples with and without contrast agent (CA), we evaluated the effect of exposures to focused, continuous wave (CW) 1.1-MHz ultrasound…”
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Rediscovering the wound hematoma as a site of hemostasis during major arterial hemorrhage by White, N. J., Mehic, E., Wang, X., Chien, D., Lim, E., St. John, A. E., Stern, S. A., Mourad, P. D., Rieger, M., Fries, D., Martinowitz, U.

“…Summary Background Treatments for major internal bleeding after injury include permissive hypotension to decrease the rate of blood loss, intravenous infusion…”
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In vitro validation of endovascular Doppler-derived flow rates in models of the cerebral circulation by McGah, P M, Nerva, J D, Morton, R P, Barbour, M C, Levitt, M R, Mourad, P D, Kim, L J, Aliseda, A

“…This study presents validation of endovascular Doppler velocimetry-based volumetric flow rate measurements conducted in a pulsatile flow loop simulating…”
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High-intensity focused ultrasound selectively disrupts the blood-brain barrier in vivo by Mesiwala, Ali H, Farrell, Lindi, Wenzel, H Jurgen, Silbergeld, Daniel L, Crum, Lawrence A, Winn, H Richard, Mourad, Pierre D

“…High-intensity focused ultrasound (HIFU) has been shown to generate lesions that destroy brain tissue while disrupting the blood-brain barrier (BBB) in the…”
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Acceleration of recovery after injury to the peripheral nervous system using ultrasound and other therapeutic modalities by Lazar, D A, Curra, F P, Mohr, B, McNutt, L D, Kliot, M, Mourad, P D

“…Taken together, these studies show the promise of various therapeutic modalities for the noninvasive treatment of peripheral nerve injury. Further progress on…”
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A model/data comparison for low-frequency bottom backscatter by MOURAD, P. D, JACKSON, D. R

“…This article describes a model for bottom backscattering strength applicable over the frequency range 100–1000 Hz. The model includes backscatter due to both a…”
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Near-normal incidence scattering from rough, finite surfaces : Kirchhoff theory and data comparison for arctic sea ice by MOURAD, P. D, WILLIAMS, K. L

“…The Kirchhoff theory is applied for the target strength of a rough, circular surface whose roughness is characterized by a two-dimensional, isotropic power-law…”
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Source localization using a reference wave to correct for oceanic variability by MOURAD, P. D, ROUSEFF, D, PORTER, R. P, AL-KURD, A

“…This paper describes a low-frequency, long-range acoustic propagation method for source localization. It is based on imaging techniques that remove the effects…”
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A review and examination of ultrasound for lipoplasty by Mourad, P D, Crum, L A

“…Ultrasonic lipoplasty occurs through a complex and describable but currently unquantified series of processes. Ample opportunity exists for the creation of…”
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Numerical simulations of heating patterns and tissue temperature response due to high-intensity focused ultrasound by Curra, F.P., Mourad, P.D., Khokhlova, V.A., Cleveland, R.O., Crum, L.A.

“…The results of this paper show-for an existing high intensity, focused ultrasound (HIFU) transducer-the importance of nonlinear effects on the space/time…”
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Activation, aggregation and adhesion of platelets exposed to high-intensity focused ultrasound by Poliachik, S L, Chandler, W L, Mourad, P D, Ollos, R J, Crum, L A

“…Using platelet-rich plasma, we investigated the effect of 1.1-MHz continuous wave high-intensity focused ultrasound (HIFU) on platelet activation, aggregation…”
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Experimental examination of growing and newly submerged sea ice including acoustic probing of the skeletal layer by WILLIAMS, K. L, GARRISON, G. R, MOURAD, P. D

“…Results of an in-situ experiment to examine acoustic parameters and scattering properties of growing and newly submerged arctic sea ice are presented. The…”
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Ultrasound accelerates functional recovery after peripheral nerve damage by MOURAD, Pierre D, LAZAR, Daniel A, CURRA, Francesco P, MOHR, Brandt C, ANDRUS, Kathleen C, AVELLIN, Anthony M, MCNUTT, Lawrence D, CRUM, Lawrence A, KLIOT, Michel

“…Axonal injury in the peripheral nervous system is common, and often it is associated with severe long-term personal and societal costs. The objective of this…”
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Surface modification of polymers with self-assembled molecular structures: multitechnique surface characterization by Kwok, C S, Mourad, P D, Crum, L A, Ratner, B D

“…A simple, one-step procedure for generating ordered, crystalline methylene chains on polymeric surfaces via urethane linkages was developed. The reaction of…”
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