Search Results - "Moura, Tales Rocha"
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1
The cap-binding site of influenza virus protein PB2 as a drug target
Published in Acta crystallographica. Section D, Structural biology (01-02-2016)“…The RNA polymerase of influenza virus consists of three subunits: PA, PB1 and PB2. It uses a unique `cap‐snatching' mechanism for the transcription of viral…”
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2
Conserved structures and dynamics in 5'-proximal regions of Betacoronavirus RNA genomes
Published in Nucleic acids research (12-04-2024)“…Betacoronaviruses are a genus within the Coronaviridae family of RNA viruses. They are capable of infecting vertebrates and causing epidemics as well as global…”
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3
Cryo-EM Structure of raiA ncRNA From Clostridium Reveals a New RNA 3D Fold
Published in Journal of molecular biology (01-12-2024)“…[Display omitted] •Cryo-EM reveals the 3D structure of raiA ncRNA from Clostridium sp. CAG 138.•raiA ncRNA adopts a unique globular architecture with a novel…”
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4
Crystal structure of the lectin of Camptosema pedicellatum: implications of a conservative substitution at the hydrophobic subsite
Published in Journal of biochemistry (Tokyo) (01-07-2012)“…Lectins have been used as models for studies of the molecular basis of protein-carbohydrate interaction and specificity by deciphering codes present in the…”
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Structural studies of an anti-inflammatory lectin from Canavalia boliviana seeds in complex with dimannosides
Published in PloS one (27-05-2014)“…Plant lectins, especially those purified from species of the Leguminosae family, represent the best-studied group of carbohydrate-binding proteins. Lectins…”
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6
A novel CD34-specific T-cell engager efficiently depletes acute myeloid leukemia and leukemic stem cells in vitro and in vivo
Published in Haematologica (Roma) (10-02-2022)“…Less than a third of acute myeloid leukemia (AML) patients are cured by chemotherapy and/or hematopoietic stem cell transplantation (HSCT), highlighting the…”
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7
Structural analysis of ConBr reveals molecular correlation between the carbohydrate recognition domain and endothelial NO synthase activation
Published in Biochemical and biophysical research communications (20-05-2011)“…► Canavalia brasiliensis seed lectin crystal structure and the prediction of dimannoside biding by docking were used to structure/function analysis. ► The…”
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RNA tertiary structure prediction in CASP15 by the GeneSilico group: Folding simulations based on statistical potentials and spatial restraints
Published in Proteins, structure, function, and bioinformatics (01-12-2023)“…Ribonucleic acid (RNA) molecules serve as master regulators of cells by encoding their biological function in the ribonucleotide sequence, particularly their…”
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Prp19/Pso4 Is an Autoinhibited Ubiquitin Ligase Activated by Stepwise Assembly of Three Splicing Factors
Published in Molecular cell (15-03-2018)“…Human nineteen complex (NTC) acts as a multimeric E3 ubiquitin ligase in DNA repair and splicing. The transfer of ubiquitin is mediated by Prp19—a…”
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Vasodilator effects of Diocleinae lectins from the Canavalia genus
Published in Naunyn-Schmiedeberg's archives of pharmacology (01-12-2009)“…This study investigated and compared vascular actions of leguminous lectins obtained from the Canavalia genus ( Canavalia brasiliensis , Canavalia gladiata ,…”
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11
A novel CD34-specific T-cell engager efficiently depletes acute myeloid leukemia and leukemic stem cells in vitro and in vivo
Published in Haematologica (Roma) (01-08-2022)Get full text
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12
A Novel CD34-Specific T-Cell Engager Efficiently Depletes Stem Cells and Acute Myeloid Leukemia Cells in Vitro and In Vivo
Published in BLOOD (2021)“…ASH Abstract. Intro Acute myeloid leukemia (AML) and high-risk myelodysplastic syndromes (MDS) are poor prognosis hematological malignancies characterized by…”
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Journal Article Conference Proceeding -
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Crystallization and preliminary X-ray diffraction analysis of the lectin from Canavalia boliviana Piper seeds
Published in Acta crystallographica. Section F, Structural biology and crystallization communications (01-03-2009)“…Plant lectins are the most studied group of carbohydrate‐binding proteins. Despite the high similarity between the members of the Diocleinae subtribe…”
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